Clinical trials
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phasePrevalence of FGFR2b Protein Overexpression in Advanced Gastric Cancers During Prescreening for the Phase III FORTITUDE-101 Trial
Prevalence of FGFR2b Protein Overexpression in Advanced Gastric Cancers Study Overview Purpose: FGFR2b protein overexpression is an important biomarker in gastric cancer. This study evaluated how common FGFR2b overexpression is in nearly 3,800 tumor samples from patients with advanced or metastatic gastric cancer (GC) during the prescreening for the Phase III FORTITUDE-101 trial. Methods: As […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEfficacy of videoconferencing-delivered cognitive behavioural therapy to reduce anxiety disorder severity in LGBTQ+ people: An exploratory trial protocol
Efficacy of Videoconferencing-Delivered Cognitive Behavioral Therapy for LGBTQ+ Anxiety Disorders Objective This study aims to evaluate the effectiveness of Cognitive Behavioral Therapy (CBT) delivered through videoconferencing for LGBTQ+ individuals experiencing anxiety disorders. While CBT is a proven treatment for anxiety in the general population, its effectiveness for LGBTQ+ individuals is still being explored. Methods We […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseStudy protocol for a hybrid implementation-effectiveness trial of Game Changers for Cervical Cancer Prevention in Uganda
Study Overview Title: Hybrid Trial for Cervical Cancer Prevention in Uganda Published: PLoS One, January 24, 2025 Introduction Cervical cancer (CC) is a major health issue in Uganda, being the top cause of cancer deaths among women. Unfortunately, many women do not get screened for CC. A promising solution is to train women who have […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseSymptomatic Improvement in Adults and Adolescents With Eosinophilic Esophagitis Requires Higher Systemic Dupilumab Exposure Than Histologic Response
Symptomatic Improvement in Eosinophilic Esophagitis Key Findings from Recent Study Background: This study looked at why adults and teenagers with eosinophilic esophagitis (EoE) need more doses of dupilumab compared to other conditions. Study Methods: Researchers combined results from the phase 3 LIBERTY EoE TREET study, focusing on two main goals: Percentage of patients with 6 […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseTreatment of peri-implant mucositis using an Er:YAG laser or an ultrasonic device: a randomized, controlled clinical trial
Treatment of Peri-Implant Mucositis Study Overview This study compared the effectiveness of two treatments for peri-implant mucositis: an Er:YAG laser and an ultrasonic device. The goal was to see how these treatments affected pain, appearance, and overall quality of life over six months. Methods Each patient received one dental implant treatment. They were randomly assigned […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffects of autologous serum and artificial tears on corneal sensation and tear film stability in patients with mild to moderate xerophthalmia after cataract surgery
Study on the Effects of Autologous Serum and Artificial Tears Objective We wanted to see how autologous serum combined with artificial tears affects corneal sensation and tear film stability in patients with mild to moderate dry eyes after cataract surgery. Methodology We studied 150 patients with mild to moderate dry eyes after undergoing cataract surgery […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseLipidomic profiling of plasma from patients with multiple myeloma receiving bortezomib: an exploratory biomarker study of JCOG1105 (JCOG1105A1)
Lipidomic Profiling in Multiple Myeloma Patients Study Overview This study investigates how lipid profiling of blood samples can help identify biomarkers for predicting the effects of bortezomib (Btz) in patients with multiple myeloma (MM). Purpose The aim is to find specific metabolites that relate to toxicities and the effectiveness of Btz in newly diagnosed MM […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseHealth Literacy and Metabolic Control in Individuals Diagnosed with Type 2 Diabetes Mellitus: A Cluster Randomized Clinical Trial
Health Literacy and Metabolic Control in Type 2 Diabetes Patients Introduction People with type 2 diabetes struggle with managing their condition. A significant factor is their low health literacy, which affects how well they access, understand, and use health information to take care of themselves. Hypothesis We believe that individuals with diabetes who take part […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseComparative Evaluation of Regain of Consciousness in Dexmedetomidine-Propofol versus Ketamine-Propofol in the Pediatric Cardiac Catheterization Procedure under Sedation using BIS Monitoring: A Randomized Prospective Study
Comparative Evaluation of Sedation in Pediatric Cardiac Procedures Study Overview This study compares two sedation methods for children with congenital heart diseases undergoing cardiac catheterization: Dexmedetomidine-Propofol (DP) and Ketamine-Propofol (KP). The aim was to determine which combination allows for faster recovery of consciousness. Key Findings Faster Recovery: Children in the KP group regained consciousness significantly […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseImpact of the initiation of isCGM soon after type 1 diabetes mellitus diagnosis in adults on glycemic indices and fear of hypoglycemia: a randomized controlled trial
Impact of Early Continuous Glucose Monitoring in Adults with Type 1 Diabetes Background Continuous glucose monitoring (CGM) helps manage blood sugar levels and improves quality of life. However, there is limited information on its effects on newly diagnosed type 1 diabetes (T1DM) patients. Aim This study aimed to evaluate how starting intermittently scanned CGM (isCGM) […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Outcomes in stage IIA versus stage IIB/III in the PALLAS trial [ABCSG-42/AFT-05/PrE0109/BIG-14-13])
Outcomes in Stage IIA vs. Stage IIB/III in the PALLAS Trial Background The PALLAS trial studied whether adding palbociclib to standard hormone therapy could lower the chances of breast cancer returning. This analysis focused on patients with lower risk stage IIA compared to those with higher stage diseases. Methods PALLAS was a large, international study […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseClinical application of third-generation dual-source CT-based dynamic imaging reconstruction for pulmonary embolism imaging
Clinical Application of Advanced CT Imaging for Pulmonary Embolism Background This study evaluates the effectiveness of a new CT imaging method for diagnosing pulmonary embolism (PE). It focuses on improving the scanning process using advanced technology. Methods A total of 82 patients with pulmonary embolism participated in the study. They were randomly assigned to two […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseComparison of the two treatment methods in primary hyperparathyroidism due to solitary parathyroid adenoma, Ultrasound-guided percutaneous alcohol ablation vs. parathyroidectomy: a randomized controlled trial
Comparison of Treatment Methods for Primary Hyperparathyroidism Study Overview This study compares two treatments for primary hyperparathyroidism (pHPT) caused by a solitary parathyroid adenoma: Ultrasound-guided percutaneous alcohol ablation (PEA) and parathyroidectomy (PTx). PTx is the standard treatment for symptomatic patients, while PEA is a less invasive option for those who cannot undergo surgery. Research Method […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffectiveness of high intensity laser treatment in partial supraspinatus tendon tears: a randomised controlled trial
Effectiveness of High-Intensity Laser Treatment for Partial Supraspinatus Tendon Tears Study Overview The most frequent cause of rotator cuff injury is supraspinatus tendon tears (STTs). High-intensity laser therapy (HILT) is a promising non-surgical treatment. This study aimed to compare HILT with ultrasound (US) therapy in patients with partial STTs. Key Findings Fifty patients aged 18-75 […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseCombined oral supplementation with magnesium plus vitamin D alleviates mild to moderate depressive symptoms related to long-COVID: an open-label randomized, controlled clinical trial
Summary of Clinical Trial Findings Study Focus This study investigated how well oral supplements of magnesium and vitamin D can reduce mild to moderate depression symptoms in people suffering from long-COVID. Key Outcomes Participants: 60 individuals aged around 53 years with low magnesium and vitamin D levels, along with mild to moderate depression. Method: Participants […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Effect of stress management based self-care counseling on glycemic control in women with gestational diabetes mellitus: a randomized controlled trial study
Effect of Stress Management on Blood Sugar Control in Pregnant Women with Gestational Diabetes Study Overview This study explores how stress management counseling can help control blood sugar levels in women with gestational diabetes mellitus (GDM). Stress can worsen GDM, so the goal was to see if self-care counseling could improve health outcomes. Study Details […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseStudy protocol of the PRINCESS trial-PReoperative INtermittent fasting versus CarbohydratE loading to reduce inSulin resiStance versus standard of care in orthopaedic patients: a randomised controlled trial
Study Overview of the PRINCESS Trial The PRINCESS trial investigates how different preoperative nutritional strategies affect insulin resistance in orthopedic patients undergoing surgery. Background Surgery can cause metabolic stress, leading to insulin resistance (IR) and high blood sugar levels. This can result in complications after surgery. Traditional fasting before surgery may worsen these issues. However, […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEfficacy of a Mobile Health-Based Behavioral Treatment for Lifestyle Modification in Type 2 Diabetes Self-Management: Greenhabit Randomized Controlled Trial
Efficacy of a Mobile Health-Based Behavioral Treatment for Lifestyle Modification in Type 2 Diabetes Self-Management: Greenhabit Randomized Controlled Trial Background Using digital tools can help patients with type 2 diabetes (T2D) manage their health better. Objective This study looks at whether the Greenhabit mobile app improves T2D management compared to standard care. Methods A 12-week […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseIntegrating Videoconferencing Therapist Guidance Into Stepped Care Internet-Delivered Cognitive Behavioral Therapy for Child and Adolescent Anxiety: Noninferiority Randomized Controlled Trial
Integrating Videoconferencing Therapist Guidance Into Stepped Care Internet-Delivered Cognitive Behavioral Therapy for Child and Adolescent Anxiety Study Overview This study explores a new way to deliver cognitive behavioral therapy (CBT) for children and adolescents with anxiety. It compares two methods: ICBT-SC[VC]: Internet-delivered CBT with therapist guidance through videoconferencing only when needed. ICBT-TG[VC]: Full internet-delivered CBT […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
HEalth-Related Quality of Life-Intervention in Survivors of Breast and Other Cancers Experiencing Cancer-Related Fatigue and Associated Cognitive Symptoms Using TraditionAL Chinese Medicine: The ‘HERBAL’ Trial
Health-Related Quality of Life Intervention for Cancer Survivors: The ‘HERBAL’ Trial Introduction This study explores the use of traditional Chinese medicine (TCM) to help cancer survivors deal with fatigue and cognitive symptoms. We specifically looked at a TCM blend called modified Xiang Bei Yang Rong Tang (XBYRT) and compared its effects on quality of life […] ➡️➡️➡️