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Community Versus Facility-Based Services to Improve the Screening of Active Hepatitis C Virus Infection in Cambodia: The ANRS 12384 CAM-C Cluster Randomized Controlled Trial-Protocol for a Mixed Methods Study
Community Versus Facility-Based Services for Hepatitis C Screening in Cambodia Background: Hepatitis C is a major health issue in Cambodia, especially for those over 45 years old, with a prevalence of 5%. Improving access to screening and treatment is essential for eliminating hepatitis C. Objective: This study will compare the effectiveness of community-based screening versus…
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase -
Acute severe pain in emergency department: Morphine or low-dose ketamine?
Acute Severe Pain in Emergency Department: Morphine vs. Low-Dose Ketamine Introduction Severe pain is a critical issue that can be dangerous due to its location and potential misdiagnosis. Aim This study aimed to compare the effectiveness of morphine and low-dose ketamine for treating severe pain in the emergency department. Methods We conducted a randomized open…
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase -
New Prospects for Conservative Treatment of Chronic Recurrent Cystitis in Women: Experience with the Drug Superlymph
New Solutions for Treating Chronic Recurrent Cystitis in Women: Experience with Superlymph Introduction Chronic recurrent cystitis is a common and challenging issue in urology. Traditional antimicrobial treatments often fail to provide long-term relief. Aim This study aimed to assess the effectiveness and safety of the drug Superlymph, administered through rectal and vaginal suppositories in two…
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase -
Experience with UroBest in patients with acute cystitis
Experience with UroBest in Patients with Acute Cystitis Study Overview AIM: This study aimed to assess how effective and safe UroBest is for treating acute cystitis compared to similar products. Methods The study involved 90 patients aged 18 to 49 with acute cystitis. They were treated at various clinical sites in Russia. All patients received…
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase -
Study of the pharmacokinetics of extended release sildenafil
Study of the Pharmacokinetics of Extended Release Sildenafil Purpose of the Study The study aimed to compare how the drug Vildegra, approved in Russia, behaves in the body compared to the original drug, Viagra. Materials and Methods The study was designed as a prospective, open-label trial involving healthy male volunteers. A total of 48 men,…
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase -
Quality of Life in Subcutaneous or Transvenous Implantable Cardioverter-Defibrillator Patients: A Secondary Analysis of the PRAETORIAN Trial
Quality of Life in Patients with Subcutaneous or Transvenous Implantable Cardioverter-Defibrillators Study Overview The subcutaneous implantable cardioverter-defibrillator (S-ICD) was designed to reduce complications linked to the transvenous version (TV-ICD). This study looks at how these two devices affect patients’ quality of life. Methodology In the PRAETORIAN trial, patients needing an implantable cardioverter-defibrillator were randomly assigned…
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase -
Efficacy of Terpinen-4-ol Combined With Eyelid Deep Cleaning for the Treatment of Demodex Blepharitis: A Randomized, Open-Label Trial
Efficacy of Terpinen-4-ol Combined With Eyelid Deep Cleaning for Demodex Blepharitis Purpose This study aimed to test how well a treatment using terpinen-4-ol (T4O) and eyelid deep cleaning works for Demodex blepharitis. Methods We conducted a trial with 40 patients diagnosed with Demodex blepharitis at the Cornea Specialty Clinic of Hankou Aier Eye Hospital. Participants…
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase -
Clinical evaluation of the efficacy of focused extracorporeal shock-wave therapy in patients with cervical spondylosis: A randomized control trial
Clinical Trial on Focused Extracorporeal Shock-Wave Therapy for Cervical Spondylosis Study Overview Extracorporeal Shock Wave Therapy (ESWT) is a modern physiotherapy treatment that helps with muscle and bone issues. This study specifically looked at how effective focused ESWT (fESWT) is for relieving pain and improving function in patients with cervical spondylosis, a neck condition. Study…
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase -
Care to Explain? AI Explanation Types Differentially Impact Chest Radiograph Diagnostic Performance and Physician Trust in AI
Understanding the Impact of AI Explanations on Radiology Study Overview This study explores how different types of AI explanations affect the ability of doctors to diagnose chest X-rays and their trust in AI. It aimed to find out if AI explanations help or hinder doctors in making decisions. Research Details The study was conducted from…
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase -
Survival outcomes of population-wide colonoscopy screening: reanalysis of the NordICC data
Survival Outcomes of Colonoscopy Screening: Key Findings Background Colonoscopy is a common method used to screen for colorectal cancer, but strong evidence supporting its effectiveness is lacking. The NordICC trial, the first randomized study on colonoscopy screening, showed no clear benefits for the general population. However, some benefits were suggested for specific groups. This study…
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase