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Assessment of two methods for detecting carious dentin: an in vitro study
Assessment of Carious Dentin Detection Methods Study Overview This study aimed to compare two methods for detecting carious dentin: Caries Finder and BlueCheck. We wanted to see if these methods work as well as the traditional visual and tactile methods. Study Method We used 65 extracted human teeth with specific lesions. The teeth were divided…
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase -
Predictors and Impact of Disclosure Efficacy Among Cancer Survivors
Predictors and Impact of Disclosure Efficacy Among Cancer Survivors Background Cancer survivors who talk about their diagnosis and experiences gain many benefits, including a better quality of life. Understanding what helps these survivors share their stories is important. One key factor is “disclosure efficacy,” which means feeling confident about sharing personal information. Aims In the…
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase -
Neural Mechanism of Cognitive Reserve in Acupuncture Stimulation: Protocol for a Randomized, Placebo-Controlled Functional Near-Infrared Spectroscopy Trial
Neural Mechanism of Cognitive Reserve in Acupuncture Stimulation Study Overview This study focuses on understanding how acupuncture may help with cognitive reserve (CR) in aging and dementia. CR is the brain’s ability to cope with damage and is important for predicting dementia outcomes. Why This Study Matters Dementia currently has no cure, making early diagnosis…
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase -
Efficacy of Microneedle Fractional Radiofrequency Combined With Topical Insulin for the Treatment of Facial Atrophic Acne Scars: A Split-Face, Double-Blinded, Randomized, Placebo-Controlled Trial
Efficacy of Microneedle Fractional Radiofrequency Combined With Topical Insulin for Treating Acne Scars Study Overview This study explored how effective combining topical insulin (TI) with microneedle fractional radiofrequency (MFR) is for treating atrophic acne scars. Key Findings Improved Results: Participants showed significant improvement in scar volume after treatment. Effective Treatment: The combination of MFR and…
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase -
A randomised clinical trial comparing a surgical approach for treatment of peri-implantitis to non-surgical debridement with adjunctive diode laser therapy
A Randomised Clinical Trial on Peri-Implantitis Treatment Objective The study aimed to compare the effectiveness of non-surgical treatment with diode laser therapy to surgical methods for managing peri-implantitis. Materials and Methods Forty patients with peri-implantitis were divided into two groups: Test Group: Received mechanical cleaning and diode laser therapy on Days 0, 7, and 14.…
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase -
The Impact of Listening to Music During MRI-Fusion Prostate Biopsy Procedures on Pain and Anxiety Levels: A Randomized Controlled Trial
The Impact of Listening to Music During MRI-Fusion Prostate Biopsy Procedures on Pain and Anxiety Levels Study Overview This study explores how listening to music during combined biopsy (CBx) procedures affects pain and anxiety levels in patients. CBx combines two types of biopsies for better diagnosis but can be more uncomfortable than traditional methods. Methods…
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase -
30% Supramolecular Salicylic Acid Improved Symptoms and Skin Barrier in Papulopustular Rosacea
30% Supramolecular Salicylic Acid Improves Rosacea Symptoms Study Overview Rosacea is a common skin condition affecting many individuals globally. Managing this condition can be difficult for dermatologists. Study Purpose This study aimed to evaluate how effective and safe a 30% supramolecular salicylic acid (SSA) treatment is for papulopustular rosacea. The focus was on: Reducing skin…
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase -
Effect of remimazolam tosilate for injection (HR7056) versus sevoflurane on the incidence of postoperative delirium in older patients undergoing total hip arthroplasty: study protocol for a prospective, multicentre, two-arm, parallel-group, randomised controlled trial
Study Overview This study compares the effects of two sedatives, remimazolam tosilate and sevoflurane, on the occurrence of postoperative delirium (POD) in older patients undergoing total hip surgery. Why This Study Matters Postoperative delirium is a common issue after surgery, especially in older adults. It can lead to serious complications. Understanding which sedative may reduce…
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase -
Intraindividual crossover comparison of gadobenate dimeglumine-enhanced and gadoxetate disodium-enhanced MRI for characterizing focal liver lesions
Intraindividual Comparison of MRI Contrast Agents for Liver Lesions Study Overview This study compared two MRI contrast agents, gadobenate and gadoxetate, in assessing liver lesions in the same individuals. Methodology A total of 140 adults participated, undergoing two MRI scans within 7-14 days. One scan used gadobenate (0.05 mmol/kg) and the other used gadoxetate (0.025…
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase -
Digital Mental Health Screening, Feedback, and Referral System for Teens With Socially Complex Needs: Protocol for a Randomized Controlled Trial Integrating the Teen Assess, Check, and Heal System into Pediatric Primary Care
Digital Mental Health Screening for Teens: A New Approach Study Overview: This study focuses on improving mental health care for teens with complex needs through a digital system called the Teen Assess, Check, and Heal (TeACH) System. By integrating this system into pediatric primary care (PPC), we aim to enhance access and reduce barriers to…
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase