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Case Report: Long-Term Survival of a Patient with Cerebral Metastasized Ovarian Carcinoma
Treatment with Personalized Peptide Vaccine and Anti-PD-1 Therapy
- Ovarian cancer is a common and deadly cancer among women, especially in advanced stages.
- A 49-year-old patient with stage III ovarian cancer received a personalized peptide vaccine and anti-PD-1 therapy after standard treatments failed.
- The vaccine targeted specific mutations in the tumor and was administered over 50 months.
- Anti-PD-1 therapy was given to prevent further disease progression.
- Tests showed strong immune responses and T-cell activation against the vaccinated peptides.
- Genetic and immunohistochemical analysis revealed a potential tumor escape mechanism.
- The study suggests that personalized peptide vaccines could be beneficial for cancer stages with limited treatment options.
- Further investigation into the loss of Beta-2 microglobulin as a tumor escape mechanism is recommended in clinical trials using anti-cancer vaccines and immune-checkpoint inhibitors.
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