Dr M. Trenton

CLINICAL TRIAL RESULTS A randomized controlled trial to compare the effects of time-restricted eating versus Mediterranean diet on symptoms and quality of life in bipolar disorder Background: This study aimed to compare the effectiveness of time-restricted eating (TRE) with the Mediterranean diet for individuals with bipolar disorder (BD) experiencing sleep or circadian rhythm disturbances. Methods: […] ➡️➡️➡️

Quantitative Analysis of Essential Oil Mouthrinses on Plaque Microbiome BMC Oral Health. 2024 May 18;24(1):578. doi: 10.1186/s12903-024-04365-9. Background: The oral cavity’s microorganisms greatly impact oral health. This study introduces a new method to measure the effects of essential oil mouthrinses on dental plaque microbiome using DNA standards and metagenome sequencing. Methods: In a randomized trial, […] ➡️➡️➡️

Study Title The influence of mindfulness meditation combined with progressive muscle relaxation training on the clinical efficacy and quality of life of patients with sarcopenia receiving haemodialysis: a randomised controlled trial Key Findings The study found that combining mindfulness meditation with progressive muscle relaxation training significantly improved exercise capacity and kidney disease quality of life […] ➡️➡️➡️

Safety and Efficacy of Inebilizumab for Neuromyelitis Optica Spectrum Disorder End-of-Study Results from N-MOmentum Trial In a recent study published in Lancet Neurology, the safety and efficacy of inebilizumab for treating neuromyelitis optica spectrum disorder were investigated. The study included both the randomised controlled period and the open-label extension period. Key Findings 225 participants received […] ➡️➡️➡️

Feasibility and Acceptability of Tailored Health Coaching for Type 2 Diabetes Management in Saudi Arabia Key Findings The study aimed to assess the feasibility and acceptability of tailored health coaching to improve type 2 diabetes self-management in Saudi Arabia. The research involved a 12-week randomised controlled trial with 30 Saudi adults diagnosed with type 2 […] ➡️➡️➡️

Effects of Maitland Mobilization Technique on Upper Extremity Function in Stroke Survivors with Spasticity Study Overview The study aimed to explore the impact of Maitland joint mobilization technique on the recovery of upper extremity function in stroke patients with spasticity. Methods 71 patients with upper extremity flexor spasm after stroke were enrolled and randomly assigned […] ➡️➡️➡️

Key Findings from Clinical Trial Overview In diabetic macular edema (DME), hyper-reflective foci (HRF) are found in almost all patients and are linked to disease severity and progression. The study used automated analysis to examine the distribution of HRF in relation to intraretinal fluid (IRF). Practical Solutions and Value The study’s findings provide valuable insights […] ➡️➡️➡️

The Impact of Back Optic Zone Design in Orthokeratology on Visual Performance Transl Vis Sci Technol. 2024 May 1;13(5):12. doi: 10.1167/tvst.13.5.12. ABSTRACT PURPOSE: This study aimed to assess the visual performance in adolescents undergoing orthokeratology treatment with different optical zone diameters (OZDs). METHODS: The study was conducted at Tianjin Eye Hospital in June 2022, enrolling […] ➡️➡️➡️

Exploratory Biomarker Analysis in Olaparib Maintenance Therapy for Ovarian Cancer Study Overview The L-MOCA trial has shown that olaparib maintenance therapy is effective and safe for Chinese patients with platinum-sensitive relapsed ovarian cancer. This study explores the impact of homologous recombination deficiency (HRD) and programmed cell death ligand 1 (PD-L1) expression on olaparib’s effectiveness. Biomarker […] ➡️➡️➡️

Comparison of Three Diagnostic Strategies for Pulmonary Embolism Key Research Findings Pulmonary embolism (PE) is a challenging condition to diagnose and can be life-threatening when missed. This study aims to compare the effectiveness of three diagnostic strategies: planar ventilation-perfusion scan (V/Q), CT pulmonary angiography (CTPA), and single photon emission CT ventilation-perfusion scan (SPECT V/Q) in […] ➡️➡️➡️

Remote Live Stream Assessment Validity in Duchenne Muscular Dystrophy Patients Key Findings: Remote functional assessment scores strongly correlate with in-person scores. Remote assessments have the potential to reduce the burden on families by supplementing in-clinic visits. Practical Solutions and Value: Using remote live stream video evaluation for functional assessments in patients with Duchenne muscular dystrophy […] ➡️➡️➡️

Effectiveness of a Web-Based Cognitive Behavioral Self-Help Intervention for Binge Eating Disorder: A Randomized Clinical Trial Abstract Importance: Binge eating disorder (BED) causes significant emotional and physical distress, but access to specialized treatment is limited. Web-based self-help interventions offer a more accessible solution. Objective: To assess the effectiveness of a web-based cognitive behavioral self-help intervention […] ➡️➡️➡️

Pharmacogenomics, Race, and Treatment Outcome in Pediatric Acute Myeloid Leukemia ABSTRACT IMPORTANCE: Disparities in outcomes exist between Black and White patients with acute myeloid leukemia (AML), with Black patients experiencing poorer prognosis compared with their White counterparts. OBJECTIVE: To assess whether varying intensity of induction therapy to treat pediatric AML is associated with reduced disparities […] ➡️➡️➡️

Study Title: Intraoperative intravenous versus periarticular injection of glucocorticoids in improving clinical outcomes after total knee arthroplasty: A prospective, randomized and controlled study Abstract: Background: Glucocorticoids are commonly used for pain relief after total knee arthroplasty (TKA), but the best way to administer them is still debated. This study compares the effectiveness of glucocorticoids given […] ➡️➡️➡️

Effects of a respiratory and neurological rehabilitation treatment plan in post Covid-19 affected university students Practical Solutions and Value Highlights COVID-19 can lead to respiratory and neurological complications such as loss of sense of smell and taste. This study aimed to evaluate the effectiveness of a pulmonary and neurological rehabilitation program in post-SARS-CoV-2 patients. Study […] ➡️➡️➡️

Evaluating the Efficacy of an Oral Probiotic in Acne Vulgaris Study Details The study aimed to assess the effectiveness of an oral probiotic in treating acne vulgaris in patients aged 12 to 30 years. The probiotic used was a capsule containing Lacticaseibacillus rhamnosus (CECT 30031) and the cyanobacterium Arthrospira platensis (BEA_IDA_0074B). Key Findings Patients taking […] ➡️➡️➡️

Dietary Supplement Intake in Women with Breast Cancer: SUCCESS C Trial Results Background There is limited evidence supporting the benefits of dietary supplements for breast cancer patients, and they are generally not recommended by treatment guidelines. This analysis aimed to evaluate the prevalence of dietary supplement intake among women before and after a breast cancer […] ➡️➡️➡️

Non-specific Uptake of 18F-FAPI-04 in the Pancreas: Practical Solutions and Value Key Findings: This study analyzed the non-specific uptake (NSU) of 18F-FAPI in the pancreas and identified related factors. The NSU group showed higher uptake of 18F-FAPI and 18F-FDG, and was associated with a history of drinking, chronic liver diseases, and gastrectomy. Practical Solutions: Identified […] ➡️➡️➡️

Study Title: Comparison of Intramyocellular Lipid Metabolism Published in: Nat Commun. 2024 May 15;15(1):3690 Summary: The study compared intramyocellular lipid metabolism in male endurance athletes and patients with type 2 diabetes. Despite differences in insulin sensitivity and cardiometabolic risk, both groups showed increased skeletal myocyte fat storage, known as the “athlete’s paradox.” Method: The study […] ➡️➡️➡️

Unintended Deformation of Stents During Bifurcation PCI: An OCTOBER Trial Substudy Background Unintended deformation of implanted coronary stents can lead to complications such as loss of coronary access, stent thrombosis, and coronary events during follow-up. The incidence, mechanisms, and clinical outcomes of unintended stent deformations (USD) during complex bifurcation stenting are not well understood. Objectives […] ➡️➡️➡️