Dr M. Trenton

“`html Exercise Training for Hepatocellular Carcinoma Patients: A Systematic Review Background and Aim Patients with hepatocellular carcinoma (HCC) often experience reduced muscle mass and physical function, leading to higher health risks. This review aimed to assess the impact of exercise training programs on muscle mass and physical function in HCC patients. Methods Systematic search in […] ➡️➡️➡️

“`html Study Summary The study aimed to investigate the effectiveness and safety of using a combination of imaging techniques in treating wake-up stroke (WUS) patients. Methods Patients with WUS and specific imaging characteristics underwent either endovascular thrombectomy plus medical therapy or medical therapy alone. Functional outcomes were assessed using the modified Rankin scale (mRs) at […] ➡️➡️➡️

“`html Study Overview This study aimed to assess the impact of subthreshold micropulse laser (SML) in combination with anti-vascular endothelial growth factor (anti-VEGF) therapy for diabetic macular edema (DME). Research Methods Reviewed eight studies involving 493 eyes Four were randomized controlled trials and four were retrospective studies Utilized meta-analysis to analyze best-corrected visual acuity (BCVA), […] ➡️➡️➡️

“`html Practical Solutions for Mental Health Care in Nigerian Prisons Researchers developed strategies to improve mental health care in Nigerian prisons with limited resources. These strategies aimed to provide assessments, identification, and care for inmates and former inmates with mental illness. Over the study period, 74 individuals, mostly males with an average age of 33.25 […] ➡️➡️➡️

Background Colorectal cancer (CRC) rates are high among rural residents and Medicaid enrollees. Objectives To address these disparities, a modified community engagement approach called Boot Camp Translation (BCT) was used to inform messaging about CRC outreach and a mailed fecal immunochemical test program. Methods Eligible rural patients and clinic staff participated in a virtual BCT […] ➡️➡️➡️

“`html Practical Solutions and Value in CD19-Directed Therapy for DLBCL Overview Several treatment options are available for patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL). These options include monoclonal antibody therapy, antibody-drug conjugate therapy, and chimeric antigen receptor T-cell therapy (CAR-T). Challenges Assessing CD19 expression levels and determining the best treatment sequencing strategies […] ➡️➡️➡️

Comparing HIV Screening Strategies in Emergency Departments A recent study evaluated different HIV screening strategies in emergency departments to determine their cost-effectiveness and programmatic costs. Key Findings: The study compared nontargeted and two forms of targeted opt-out HIV screening in emergency departments. Results showed that nontargeted screening incurred higher costs due to an increased number […] ➡️➡️➡️

“`html Summary of Clinical Trial Findings Background Regulatory guidance for Crohn’s disease trials suggests using coprimary efficacy end points to evaluate symptoms and mucosal inflammation. This study aimed to assess the effectiveness of commonly used disease activity assessments alone and in combination. Methods Endoscopic and clinical data from 129 participants in the Study of Biologic […] ➡️➡️➡️

“`html Study Summary The study investigated the use of prebiotics and probiotics (called synbiotics when combined) to improve symptoms associated with autism spectrum disorder (ASD) in 296 children and adults diagnosed with ASD compared to 123 age-matched neurotypical controls. The study found that precision synbiotic supplementation led to improvements in gastrointestinal and ASD-related symptoms. Key […] ➡️➡️➡️

“`html Study Summary Background Recent evidence suggests a link between diabetes and increased risk of liver cancer, especially in Asian populations. Study Design A total of 968,738 adults from 20 different Asian cohort studies were analyzed to investigate the association between diabetes at baseline and the incidence and mortality of liver cancer. The analysis used […] ➡️➡️➡️

“`html Mantle Cell Lymphoma Treatment Patterns and Efficacy Key Findings: 536 patients with mantle cell lymphoma (MCL) were studied Front-line treatments included high-dose cytarabine, bendamustine, and anthracyclines Median progression-free survival (PFS) for all patients was 45 months Second-line treatments varied, with bendamustine-based regimen being the most common Median second-line PFS was little over 1 year […] ➡️➡️➡️

“`html Autosomal Dominant Osteopetrosis (ADO) Study Findings Problem: – ADO is a rare bone disease causing high bone density and skeletal fragility. – Impact on patients’ daily lives not well understood. Solution: – Developed an online registry to collect data on disease progression and patient outcomes. – Aim to measure treatment effects and guide future […] ➡️➡️➡️

“`html Motor Neuron Disease (MND) Clinical Trial Background People with MND often experience high psychological distress due to the progressive nature of the disease. This study aimed to assess the cost-effectiveness of acceptance and commitment therapy (ACT) tailored for MND patients in improving their quality of life. Methods Compared ACT plus usual care with usual […] ➡️➡️➡️

“`html FORZA Trial: Clinical Impact of μQFR, FFR, or OCT Guidance Background The FORZA trial compared the use of FFR or OCT for treatment decisions in patients with intermediate coronary lesions. μQFR, a noninvasive method, was evaluated for its clinical impact in the trial. Methods μQFR was assessed at baseline and after PCI. Primary endpoint: […] ➡️➡️➡️

“`html Assessing the Role of Chest Radiography in Diagnosing Neonatal Respiratory Distress Syndrome Practical Solutions and Value Access to chest radiography (CXR) in resource-limited areas is difficult. CXR is still widely used in diagnosing and grading neonatal respiratory distress syndrome (NRDS). A review of studies with NRDS diagnostic criteria was conducted. Out of 1,686 studies […] ➡️➡️➡️

“`html Practical Solutions and Value in Follicular Lymphoma Treatment Introduction Follicular lymphoma (FL) is a common type of non-Hodgkin lymphoma in Western countries. While FL is generally not curable, there are effective initial therapies and new treatments for relapsed or refractory disease. Treatment Options Initial treatment options for FL include active surveillance, radiotherapy, rituximab monotherapy, […] ➡️➡️➡️

“`html Study Summary The study aimed to assess the effectiveness of using urine samples to detect high-grade cervical precancer (CIN2+) caused by human papillomavirus (HPV) using two different urine collection devices. Key Findings The sensitivity of HPV testing in urine samples collected with the FVU-collection device was 90.3%, higher than the standard pot which had […] ➡️➡️➡️

“`html Study Summary: PD-1 Inhibitor Combined with SOX for Gastric Cancer Gastric cancer (GC) is a common and deadly tumor, often diagnosed at an advanced stage. Postoperative adjuvant chemotherapy for advanced GC has limited effectiveness, leading to high rates of distant metastasis and local recurrence. Objective To assess the safety and effectiveness of combining a […] ➡️➡️➡️

“`html Practical Solutions for Managing Mixed Neuroendocrine Non-Neuroendocrine Neoplasms (MiNENs) MiNENs are complex malignant tumors found in the digestive system, consisting of both neuroendocrine and non-neuroendocrine components. The diverse nature of these tumors, including different cell types and grades, can make their diagnosis and treatment challenging. Defining MiNEN and Addressing Confusion Recent changes in the […] ➡️➡️➡️

“`html Study Summary This study aims to understand the impact of matrix metallopeptidase-9 (MMP9) on arterial smooth muscle cells, atherosclerosis development in diabetic mice, and drug-naïve diabetes patients. Practical Solutions and Value Adding active human MMP9 to smooth muscle cells increased inflammation and initiated atherosclerosis in diabetic mice. In newly diagnosed drug-naïve diabetes patients, serum […] ➡️➡️➡️