Clinical trials

“`html Benefits of a Multimodal Hospital-Based Intervention Program for Primary Cardiovascular Prevention Impact on Physical Activity, Fitness, and Well-Being Physical activity and fitness are crucial for overall health. A multimodal hospital-based intervention program has been shown to improve physical activity levels, physical fitness, and overall well-being in individuals at risk of chronic diseases. The program’s […] ➡️➡️➡️

“`html A Comparative Study of the Use of Digital Technology in the Anterior Smile Experience The Impact of Digital Technology on Smile Design: A Comparative Analysis The use of digital technology in dentistry has revolutionized the anterior smile experience, offering benefits such as accurate treatment planning, streamlined workflow, and improved patient communication. One advantage is […] ➡️➡️➡️

“`html Benefits of Population Screening for Atrial Fibrillation in Reducing Stroke Risk Atrial fibrillation (AF) is a common heart condition that can lead to serious complications such as stroke. The SAFER trial aims to evaluate the benefits of early detection and treatment of AF in reducing the risk of stroke. Early Detection and Treatment Population […] ➡️➡️➡️

“`html A Randomized Controlled Pilot Trial of Primary Care Treatment Integrating Motivation and Exposure Treatment (PC-TIME) in Veterans With PTSD and Harmful Alcohol Use The Impact of PC-TIME on PTSD Symptoms and Alcohol Use in Veterans: A Randomized Controlled Pilot Trial Post-traumatic stress disorder (PTSD) and harmful alcohol use are common issues faced by veterans, […] ➡️➡️➡️

“`html Reducing Hospital Admissions for Patients with Substance Use Disorders The NavSTAR trial found that providing patient navigation for hospitalized patients with substance use disorders (SUDs) reduced subsequent inpatient admissions compared to standard treatment. Practical Solutions and Value: Implementing patient navigation intervention can help reduce readmissions for patients with comorbid SUDs. Identifying patient factors associated […] ➡️➡️➡️

“`html Study Title: Blood Interleukin-18 (IL-18) and IL-18 Binding Protein (IL-18BP) Levels Following Midline Laparotomy: A Prospective Randomized Study of Patients With Benign Disease and Patients With Cancer Abstract: Background/Aim: The study aimed to investigate the acute phase immune response (APR) in patients undergoing midline laparotomy (MLa) and its association with blood IL-18 and IL-18BP […] ➡️➡️➡️

“`html Potential Prodromal Digital Postural Sway Markers for Fragile X-Associated Tremor/Ataxia Syndrome (FXTAS) Detected via Dual-Tasking and Sensory Manipulation Summary FXTAS is a disorder that affects balance and movement in some people with a specific gene mutation. Researchers studied how different tasks and balance challenges can reveal early signs of FXTAS. They found that people […] ➡️➡️➡️

An Era of Digital Healthcare: Sensor Technologies and Telehealth Advancements in Chronic Heart Failure Management Summary Heart failure is a complex syndrome with significant impacts on patients and healthcare costs. Telehealth has tried to help, but challenges remain. It is essential to individualize in-hospital management, monitor patients continuously, and continue treatment after discharge to improve […] ➡️➡️➡️

“`html Practical Solutions for Enhancing Visual Perception A recent study introduced the phosphenotron, a device designed to improve the sensory spatial resolution of phosphenes in the visual field using non-invasive transcranial alternating current stimulation (NITACS). Key Highlights: NITACS applies weak electrical currents to the scalp or face to modulate brain activity, inducing phosphenes without external […] ➡️➡️➡️

“`html Human Herpes Virus-6 (HHV-6) Reactivation after Hematopoietic Cell Transplant and Chimeric Antigen Receptor (CAR)- T Cell Therapy: A Shifting Landscape Key Points: HHV-6B reactivation affects about half of HCT recipients and can lead to various complications. ciHHV6, a persistent form of HHV-6, can complicate diagnosis and is associated with adverse outcomes. Recent changes in […] ➡️➡️➡️

“`html Case Report: Long-Term Survival of a Patient with Cerebral Metastasized Ovarian Carcinoma Treatment with Personalized Peptide Vaccine and Anti-PD-1 Therapy Ovarian cancer is a common and deadly cancer among women, especially in advanced stages. A 49-year-old patient with stage III ovarian cancer received a personalized peptide vaccine and anti-PD-1 therapy after standard treatments failed. […] ➡️➡️➡️

“`html Evaluation of a FlpA Glycoconjugate Vaccine to Reduce Campylobacter jejuni Colonisation in Chickens Published in Vaccines (Basel) on April 9, 2024 Campylobacter is a common cause of stomach illness in humans, often linked to eating poultry. This study aimed to test a vaccine to reduce Campylobacter in chickens, which could lower the risk of […] ➡️➡️➡️

Advancing Postoperative Pain Management in Oral Cancer Patients: A Systematic Review Practical Solutions and Value The review explores postoperative pain management in oral cancer patients using a systematic approach. Highlights the practical solutions of persistent opioid use and the efficacy of adjuvant drugs, such as gabapentin. Emphasizes the value of a multimodal approach and personalized […] ➡️➡️➡️

“`html Practical Solutions and Value of Budesonide in Asthma Treatment Key Points: Inhaled corticosteroids (ICSs) revolutionized the treatment of mild-to-moderate asthma by focusing on reducing inflammation in the airways. Budesonide (BUD) offers a unique clinical profile due to its alternative kinetics, providing practical solutions for effective asthma management. Its high water solubility allows for rapid […] ➡️➡️➡️

Document Nucleoside Reverse Transcriptase Inhibitor Exposure and Alzheimer’s Disease Risk In a recent study published in Pharmaceuticals (Basel), it was found that exposure to nucleoside reverse transcriptase inhibitors (NRTIs) may be linked to a lower risk of Alzheimer’s disease (AD). This study was conducted as a retrospective cohort proof-of-concept and aimed to evaluate the incidence […] ➡️➡️➡️

“`html 68Ga-DOTA-D-Alanine-BoroPro Radiotracer for Imaging of the Fibroblast Activation Protein in Malignant and Non-Malignant Diseases Summary A new radiotracer, 68Ga-iFAP, has been developed for PET imaging to detect fibroblast activation protein (FAP) in tumors and non-malignant tissues. The radiotracer showed high specificity for FAP and provided clear visualization of glioblastoma, breast tumor, prostate cancer, and […] ➡️➡️➡️

“`html Beneficial Effect of Heat-Killed Lactic Acid Bacterium Lactobacillus johnsonii No. 1088 A randomized, placebo-controlled, double-blind, parallel-group clinical study was conducted to examine the effects of ingesting a heat-killed lactic acid bacterium, Lactobacillus johnsonii No. 1088 (LJ88) on temporal gastroesophageal reflux-related symptoms in healthy volunteers. A total of 120 healthy Japanese volunteers of both sexes, […] ➡️➡️➡️

“`html Study Title The Association between Circulating Cytokines and Body Composition in Frail Patients with Cardiovascular Disease Key Findings Frail patients have significantly reduced fat-free mass and a higher prevalence of diabetes. Several cytokines, including FGF basic and follistatin, showed associations with frailty. Multiple cytokines were found to correlate with fat-free mass, a key indicator […] ➡️➡️➡️

“`html Association between Homocysteine and Vitamin D Levels in Asymptomatic Korean Adults Summary An increased homocysteine level is a risk factor for cardiovascular disease, venous thromboembolism, cerebrovascular disease, and chronic kidney disease. Vitamin D deficiency is associated with coronary artery disease and metabolic disorders. The study included data from 1375 adults (895 men and 480 […] ➡️➡️➡️

Practical Solutions in Managing Glioblastoma Glioblastoma is a very aggressive and common type of brain tumor, which makes life difficult for patients. Their survival rate is usually around 15 months, despite advancements in technology and understanding of the tumors. However, molecular profiling has provided new data to better classify glioblastoma. This includes identifying mutations in […] ➡️➡️➡️