Clinical trials
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseCombination of a monofocal and one type of extended depth-of-focus (zonal refractive) intraocular lens (COMEDI) in bilateral cataract surgery protocol: a monocentric, randomised, parallel group trial in cataract surgery
COMEDI Study: Improving Cataract Surgery Outcomes Introduction The COMEDI study explores the benefits of combining monofocal and extended depth-of-focus (EDOF) intraocular lenses (IOLs) in cataract surgery. EDOF lenses offer a wider range of vision compared to monofocal lenses, and are a promising alternative to multifocal lenses which can cause visual side effects. Methods and Analysis […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEfficacy and Safety Evaluation of 177Lu-FAP-2286 in the Treatment of Advanced Lung Cancer
Efficacy and Safety Evaluation of 177Lu-FAP-2286 in Advanced Lung Cancer Treatment Study Overview The study aimed to assess the effectiveness and safety of peptide-targeted radionuclide therapy (PTRT) with 177Lu-FAP-2286 in patients with advanced lung cancer. Results and Findings Short-term efficacy assessment showed 44% of patients had a partial metabolic response, 33.3% had stable metabolic disease, […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phasePossibilities of Azilsartan Medoxomil for Preparation for Planned Percutaneous Coronary Intervention in Patients With Type 2 Diabetes Mellitus
Possibilities of Azilsartan Medoxomil for Preparation for Planned Percutaneous Coronary Intervention in Patients With Type 2 Diabetes Mellitus Key Findings Evaluation of the efficacy and safety of azilsartan medoxomil for preoperative preparation and improving the long-term prognosis of elective percutaneous coronary intervention (PCI) in patients with ischemic heart disease (IHD), arterial hypertension (AH), and type […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseKnee Arthroscopic Surgery in Middle-Aged Patients With Meniscal Symptoms: A 10-Year Follow-up of a Prospective, Randomized Controlled Trial
Knee Arthroscopic Surgery in Middle-Aged Patients With Meniscal Symptoms: A 10-Year Follow-up of a Prospective, Randomized Controlled Trial ABSTRACT Background: Previous evaluations of arthroscopic meniscal surgery showed little or no benefit in the short and midterm, but long-term effects were unknown. Purpose: To compare the 10-year outcomes in middle-aged patients with meniscal symptoms between those […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseA pilot study of safety and efficacy comparison of low molecular heparin calcium sequential oral anticoagulants in the treatment of cirrhotic portal vein thrombosis
Study on Anticoagulant Treatment for Portal Vein Thrombosis in Cirrhosis Patients Objective To compare the safety and effectiveness of two anticoagulant treatments for portal vein thrombosis (PVT) in cirrhosis patients. Methods Cirrhotic patients with PVT received low-molecular-weight heparin calcium (LMWH-Ca) injections for 2 weeks. They were then randomly assigned to receive either warfarin or rivaroxaban […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseTreatment of temporomandibular joint internal derangement using MESNA injection
Treatment of Temporomandibular Joint Internal Derangement using MESNA Injection Introduction The study focuses on using MESNA injection to treat temporomandibular joint (TMJ) internal derangement, targeting the inflammation that contributes to TMJ diseases. Objectives The aim was to evaluate the effectiveness of injecting MESNA directly into the TMJ for treating internal derangement. Materials and Methods A […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseTetracycline Three Times Daily Versus Four Times Daily in Bismuth-Containing Quadruple Therapy as the First-Line Treatment of Helicobacter pylori Infection: A Multicenter, Noninferiority, Randomized Controlled Trial
Tetracycline Three Times Daily Versus Four Times Daily in Bismuth-Containing Quadruple Therapy as the First-Line Treatment of Helicobacter pylori Infection: A Multicenter, Noninferiority, Randomized Controlled Trial ABSTRACT Current guidelines recommend bismuth-containing quadruple therapy for patients newly diagnosed with Helicobacter pylori (H. pylori) infection. This study aimed to compare the efficacy and safety of tetracycline administered […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEfficacy Comparison of Osteopathic Muscle Energy Techniques and Cervical Mobilization on Pain, Disability, and Proprioception in Cervical Spondylosis Patients
Efficacy Comparison of Osteopathic Muscle Energy Techniques and Cervical Mobilization on Pain, Disability, and Proprioception in Cervical Spondylosis Patients Key Findings: Cervical spondylosis (CS) causes persistent neck pain and decreased mobility. This study compared the effectiveness of osteopathic muscle energy technique (MET) and cervical mobilization (CM) on 76 CS patients. Practical Solutions: Both MET and […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseRelationship between NT-proBNP, echocardiographic abnormalities and functional status in patients with subclinical siabetic cardiomyopathy
Relationship between NT-proBNP, Echocardiographic Abnormalities and Functional Status in Patients with Subclinical Diabetic Cardiomyopathy Introduction Diabetes can lead to heart muscle disease (cardiomyopathy) through different mechanisms. The connection between natriuretic peptides, heart structure issues, and functional abilities in diabetic cardiomyopathy (DbCM) patients is not well understood. Methods In this study, 685 patients with asymptomatic DbCM […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseImplementation of integrated care for type 2 diabetes Mellitus and Periodontitis in Germany: study protocol for a practice-based and cluster-randomized trial
Implementation of Integrated Care for Type 2 Diabetes Mellitus and Periodontitis in Germany: Study Protocol for a Practice-based and Cluster-randomized Trial Background Type 2 Diabetes mellitus (T2DM) and periodontitis have common risk factors and can impact each other. However, primary care and oral health care are currently separate and do not coordinate care for patients […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Early anti-coagulation therapy in new-onset atrial fibrillation after coronary artery bypass grafting: a randomized trial pilot study
Early Anti-Coagulation Therapy in New-Onset Atrial Fibrillation after Coronary Artery Bypass Grafting: A Randomized Trial Pilot Study Background New-onset postoperative atrial fibrillation (POAF) is a common complication after coronary artery bypass grafting (CABG) surgery, increasing the risk of embolism and stroke. This study aimed to compare the feasibility and safety of Warfarin and Rivaroxaban in […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Patient-Representing Population’s Perceptions of GPT-Generated Versus Standard Emergency Department Discharge Instructions: Randomized Blind Survey Assessment
Patient-Representing Population’s Perceptions of GPT-Generated Versus Standard Emergency Department Discharge Instructions: Randomized Blind Survey Assessment ABSTRACT Discharge instructions from the emergency department (ED) to home are crucial for patient communication but often get overlooked. Generative artificial intelligence and large language models (LLMs) offer a solution to create high-quality and personalized discharge instructions. This study aimed […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseRole of Bacillus coagulans (Heyndrickxia coagulans)BCP92 in managing irritable bowel syndrome: A randomized, double-blind, multicenter, placebo-controlled clinical trial
Role of Bacillus coagulans (Heyndrickxia coagulans)BCP92 in managing irritable bowel syndrome: A randomized, double-blind, multicenter, placebo-controlled clinical trial ABSTRACT Irritable bowel syndrome (IBS) is a significant global healthcare burden, and effective intervention is crucial. This study investigated the effectiveness and safety of Bacillus coagulans BCP92, a probiotic, in managing IBS symptoms. METHODS A randomized controlled […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseTildrakizumab Real-World Effectiveness and Safety Over 64 Weeks in Patients With Moderate-to-Severe Plaque Psoriasis
Tildrakizumab Real-World Effectiveness and Safety Over 64 Weeks in Patients With Moderate-to-Severe Plaque Psoriasis Background Tildrakizumab, a treatment for moderate-to-severe plaque psoriasis, was evaluated for its real-world effectiveness and safety over 64 weeks. Methods Adults with moderate-to-severe plaque psoriasis received tildrakizumab 100 mg at specified intervals. Effectiveness was measured using body surface area affected, Physician […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseExploring the association between adherence to home-based exercise recommendations and recovery of nonspecific low back pain: a prospective cohort study
Exploring the Impact of Home-Based Exercise Adherence on Low Back Pain Recovery Key Findings Adherence to home-based exercise (HBE) recommendations is crucial in physiotherapy for low back pain (LBP) patients. This study investigated the relationship between adherence to HBE and changes in physical function, pain intensity, and recovery from LBP. Practical Solutions Adherence to HBE […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Radiofrequency ablation via catheter and transpapillary access in patients with cholangiocarcinoma (ACTICCA-2 trial) — a multicenter, randomized, controlled, open-label investigator-initiated trial
Radiofrequency Ablation for Bile Duct Cancer (ACTICCA-2 Trial) Key Findings and Practical Solutions The ACTICCA-2 trial assessed the impact of adding radiofrequency ablation (RFA) to biliary stenting in patients with unresectable bile duct cancer undergoing palliative systemic therapy. Patients were randomized to receive either RFA plus bile duct stenting or bile duct stenting alone, with […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseImpact of a community pharmacy-based medication therapy management program on clinical and humanistic outcomes in patients with uncontrolled diabetes: a randomised controlled trial
Impact of a Community Pharmacy-Based Medication Therapy Management Program on Clinical and Humanistic Outcomes in Patients with Uncontrolled Diabetes: A Randomised Controlled Trial Abstract This study aimed to assess the impact of a community pharmacy (CP)-based medication therapy management (MTM) program on the health and satisfaction of patients with uncontrolled diabetes. Patients were randomly assigned […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseVonoprazan-amoxicillin dual therapy for Helicobacter pylori eradication in Chinese population: A prospective, multicenter, randomized, two-stage study
Vonoprazan-amoxicillin Dual Therapy for Helicobacter Pylori Eradication in Chinese Population Study Overview This study aimed to assess the effectiveness of Vonoprazan-amoxicillin dual therapy (VAT) for treating Helicobacter pylori (H. pylori) in the Chinese population. Key Findings The study found that VAT administered for 10 or 14 days achieved a higher eradication rate of H. pylori […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
A randomised controlled trial study on the effectiveness of high-fidelity simulation in enhancing skills among undergraduate medical students
Study on High-Fidelity Simulation for Medical Student Skills Enhancement Published in Med J Malaysia, July 2024 Introduction: This study compared the effectiveness of high-fidelity simulation (HFS) versus video-assisted lecture (VAL) in enhancing and retaining skills among undergraduate medical students. HFS provides realistic hands-on experience in a safe environment, while VAL involves interactive video-based teaching. Materials […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffect of nano-curcumin supplementation on cardiometabolic risk factors, physical and psychological quality of life, and depression in patients with coronary slow flow phenomenon: a randomized double-blind clinical trial
Effect of Nano-Curcumin Supplementation on Cardiometabolic Risk Factors and Quality of Life Key Findings from Clinical Trial Researchers conducted a randomized double-blind clinical trial to investigate the effects of a highly bioavailable curcumin supplement on patients with coronary slow flow phenomenon (CSFP). The study involved 42 patients, aged 35-70 years, with body mass index between […] ➡️➡️➡️