Clinical trials

Summary of Clinical Study on Qingfei Paidu Granules and Nonpharmacological Interventions for Asymptomatic COVID-19 Patients Background The study evaluated the effectiveness of Qingfei Paidu Granules (QFPG) and nonpharmacological interventions in managing asymptomatic novel coronavirus infection, acknowledging the significant role of Traditional Chinese Medicine (TCM) in pandemic intervention. Methods Asymptomatic individuals were randomly assigned to three […] ➡️➡️➡️

Comparison of Atorvastatin and Rosuvastatin Effects on Bone Turnover in Postmenopausal Women Key Findings: • Statins, commonly used for dyslipidemia, may have additional benefits on bone health. • This study compared the impact of atorvastatin and rosuvastatin on bone turnover in postmenopausal women. • After 12 months, atorvastatin showed potential superiority in inhibiting adverse changes […] ➡️➡️➡️

Neuromuscular Electrical Stimulation for Physical Function Maintenance during Hematopoietic Stem Cell Transplantation: Study Protocol Overview Hematopoietic stem cell transplantation (HCT) is a common treatment for blood cancers but can lead to long-term functional impairment, fatigue, and decreased quality of life. Traditional exercise is not consistently recommended or maintained by patients. This study aims to assess […] ➡️➡️➡️

Study Title: A Digital Cognitive-Physical Intervention for Attention-Deficit/Hyperactivity Disorder: Randomized Controlled Trial Background ADHD is a common neurodevelopmental disorder in children. This study aimed to assess the effectiveness of BrainFit, a digital intervention combining cognitive and exercise training, in reducing ADHD symptoms and improving executive function in school-aged children. Methods The study included 90 children […] ➡️➡️➡️

Long-Term Effect of Home Blood Pressure Self-Monitoring Plus Medication Self-Titration for Patients With Hypertension: A Secondary Analysis of the ADAMPA Randomized Clinical Trial Summary: BP self-monitoring and self-titration of antihypertensive medication, in combination with primary-care nursing involvement, were found to effectively lower blood pressure in the longer term without increasing health care use or adverse […] ➡️➡️➡️

Comparison of Treatments for Lateral Epicondylitis Study Overview This study compared the effectiveness of local massage, corticosteroid injection, and extracorporeal shock wave therapy (ESWT) in treating lateral epicondylitis (LE). Key Findings ESWT showed superior results compared to the other treatments, with significant improvements in clinical evaluation scores at the six-month follow-up. Practical Solutions and Value […] ➡️➡️➡️

Paraxanthine Improves Cognitive Function After Exercise Study Details Researchers investigated the effects of paraxanthine (PX) and caffeine (CA) on cognitive function after exercise. PX, a caffeine metabolite, was found to enhance cognitive performance without the limitations of caffeine habituation and genetic sensitivity. Method 12 trained runners were given different treatments in a double-blind, randomized, crossover […] ➡️➡️➡️

Cost-effectiveness and Cost-benefit of Fluoride Varnish for Caries Prevention Summary This study evaluated the cost-effectiveness and cost-benefit of fluoride varnish (FV) interventions for preventing caries in the first permanent molars (FPMs) among children in rural areas in Guangxi, China. The findings suggest that a comprehensive intervention combining FV application with oral health education is more […] ➡️➡️➡️

Study Overview OCD imposes significant burdens and has been exacerbated by the COVID-19 pandemic. This study aims to develop and validate a prevention program for at-risk adults utilizing cognitive-behavioral therapy and exposure response prevention techniques. Methods The study will involve a single-blind, randomized controlled trial comparing the prevention program to a waitlist control group. At-risk […] ➡️➡️➡️

Comparing Text Messaging and Pillbox Organizers for Heart Failure Medication Adherence Background Heart failure affects millions and non-adherence to medication is a common problem. New reminders like text messaging show promise in improving adherence. Methods 189 heart failure patients were randomly assigned to tailored text messaging (TTM), pillbox organizers, or control. Medication adherence was measured […] ➡️➡️➡️

Cryoneurolysis versus Radiofrequency Ablation for Chronic Low Back Pain Key Findings: A study compared cryoneurolysis and radiofrequency (RF) with a placebo for patients with chronic low back pain. The primary goal was to assess patient global impression of change (PGIC), pain intensity, function, and quality of life over a 1-year period. Study Design: The research […] ➡️➡️➡️

Managing Children with Frequent Respiratory Infections and Wheezing: A New Study Background Preschoolers often suffer from respiratory infections (RIs) leading to wheezing. This study explores the effectiveness and safety of a new multi-component nasal spray in treating these symptoms. Methods Preschoolers were either given the new nasal spray (Saflovir) or standard therapy. The outcomes measured […] ➡️➡️➡️

Efficacy of Pulse Methylprednisolone in Treatment of Acute Respiratory Distress Syndrome due to Malaria: A Randomized Controlled Clinical Trial Objective The study aimed to assess the effectiveness of pulse methylprednisolone (MPS) therapy in patients with malaria-related acute respiratory distress syndrome (ARDS). Materials and Methods The trial involved 44 patients in a randomized, single-blind, placebo-controlled study. […] ➡️➡️➡️

Varying Clinical Effectiveness of Platelet-Rich Plasma Injections in Knee Osteoarthritis Objective: To study the effectiveness of single, triple, and quintuple platelet-rich plasma injections in patients with knee osteoarthritis. Methods: – 120 patients with knee osteoarthritis were divided into three groups: PRP1, PRP3, and PRP5. – Patients were evaluated using Visual Analogue Scale (VAS) and Western […] ➡️➡️➡️

Study Summary: Concentrated Growth Factor and Sodium Hyaluronate for Temporomandibular Joint Osteoarthritis Objective To assess the impact of concentrated growth factor (CGF) combined with sodium hyaluronate (SH) on temporomandibular joint osteoarthritis (TMJOA). Methods Sixty TMJOA patients were divided into control and experimental groups. The experimental group received CGF + SH, while the control group received […] ➡️➡️➡️

Effectiveness and Feasibility of 5G-Based Remote Interactive Ultrasound Training in Critical Care BMC Med Educ. 2024 May 8;24(1):514. doi: 10.1186/s12909-024-05485-0. Background: Ultrasound is extensively used in critical care, and remote ultrasound training through 5G technology is becoming more common. This study aimed to assess the effectiveness of 5G-based remote interactive ultrasound training for critical care […] ➡️➡️➡️

Effect of Er,Cr:YSGG Laser-Assisted Periodontal Therapy Practical Solutions and Value This clinical trial aimed to show the effectiveness of Er,Cr:YSGG laser-assisted therapy in treating periodontitis patients during the early healing period of 8 weeks. Key Findings The study involved 12 patients with advanced periodontitis, and the results showed that the laser-assisted therapy led to greater […] ➡️➡️➡️

Selenium Supplementation and Gestational Diabetes: A Randomised Controlled Trial Objective To evaluate the impact of selenium supplementation on blood glucose levels in women with gestational diabetes mellitus (GDM). Study Design Randomised controlled trial conducted at the Department of Internal Medicine, Istanbul Medipol University, Faculty of Medicine, Istanbul, Turkiye, from February to July 2023. Methodology Pregnant […] ➡️➡️➡️

Comparison of Anterior Cervical Discectomy and Fusion (ACDF) versus Cervical Disc Replacement (CDR) for Cervical Disc Disease Study Details: Researchers compared the radiological outcomes and development of heterotopic ossification (HO) in patients who underwent single-segment ACDF and CDR for cervical disc herniation to evaluate their impact on surgical success. Study Duration: January 2020 to June […] ➡️➡️➡️

TLR Agonists in Glioma Treatment: Clinical Trial Results Key Points: In a phase II clinical trial, TLR agonists poly-ICLC and resiquimod were combined with autologous tumor lysate-pulsed dendritic cell vaccination in patients with malignant gliomas. The goal was to assess the best combination to boost immune response while ensuring safety. The combination was safe and […] ➡️➡️➡️