Clinical trials

Study Protocol for Evaluation of Calcium Dobesilate Efficacy on SARS-CoV-2 Viral Load in COVID-19 Outpatients Key Highlights The CADOVID trial aims to assess the effectiveness and safety of Calcium Dobesilate (CaD) in reducing SARS-CoV-2 viral load and mitigating persistent COVID-19 symptoms in non-hospitalized adult patients diagnosed with COVID-19. The trial is a randomized, placebo-controlled, double-blind, […] ➡️➡️➡️

Did diet compliance and remission reduce oxidative stress in celiac patients? Rev Assoc Med Bras (1992). 2024 May 3;70(4):e20231120 OBJECTIVE: This study aimed to investigate the impact of remission status on thiol-disulfide balance in celiac patients, providing insights into the effect of oxidative stress and inflammation resulting from non-compliance with the diet. METHODS: A total […] ➡️➡️➡️

Rapid and Sustained Antidepressant Effects of Intravenous Ketamine Key Findings Results from a clinical trial showed that intravenous ketamine led to rapid and significant improvements in symptoms of major depressive disorder (MDD) and suicidal ideation. Study Details The trial involved 64 patients with treatment-resistant MDD, who were randomly assigned to receive either ketamine or a […] ➡️➡️➡️

Efficacy and safety of 3D magnetically assisted capsule endoscopy (3D MACE) for upper gastrointestinal and small bowel examination Abstract Magnetically assisted capsule endoscopy (MACE) has shown potential for examining the upper gastrointestinal tract. This clinical study aimed to assess the efficacy and safety of a novel 3D MACE system for simultaneous upper gastrointestinal and small […] ➡️➡️➡️

Resistance Prehabilitation in Valvular Cardiac Surgery: A Clinical Trial Protocol Introduction Cardiovascular diseases (CVD) often require major surgery for treatment. Fast-track rehabilitation programs have shown promise in reducing postoperative complications and hospital stays. This study aims to assess whether adding resistance training (RT) to cardiac exercise-based prehabilitation can decrease intensive care unit (ICU) length of […] ➡️➡️➡️

Antibacterial Therapy for Acute Streptococcal Tonsillopharyngitis: Results of a Comparative Clinical Trial Background Acute tonsillopharyngitis is a common respiratory tract infection. Penicillin antibiotics like amoxicillin + clavulanic acid are often prescribed for bacterial causes. Dispersible forms of antibiotics have advantages over film-coated tablets, with better pharmacokinetic parameters, increasing effectiveness, safety, and patient compliance. Aim To […] ➡️➡️➡️

Phase 3b Study of Venetoclax and Azacitidine or Decitabine in Outpatient Setting for Acute Myeloid Leukemia Key Findings: Venetoclax combined with azacitidine or decitabine is approved for treating newly diagnosed acute myeloid leukemia (ND AML) in patients unable to undergo intensive chemotherapy. This study assessed the effectiveness and safety of this combination in a community-based […] ➡️➡️➡️

Summary of DIATEC Trial: Improving In-Hospital Diabetes Management Background Up to 20% of hospitalized patients have diabetes, leading to increased mortality, morbidity, and hospital stays. The DIATEC trial aims to improve in-hospital diabetes management strategies. Methods The trial is a two-armed, two-site, prospective randomised open-label blinded endpoint (PROBE) trial. Non-critically ill hospitalised patients with type […] ➡️➡️➡️

An mHealth Intervention for Gay and Bisexual Men’s Health in Romania: Clinical Trial Protocol Background The Comunică intervention aims to reduce HIV risk among gay and bisexual men in Romania, where stigma contributes to high HIV incidence. It involves live text-based counseling sessions using motivational interviewing and cognitive behavioral therapy skills. Objective This paper describes […] ➡️➡️➡️

Results from the LIVING Study: Predicting Postpartum Diabetes in Women with Gestational Diabetes Objective: To investigate the link between abnormal glucose values on antenatal oral glucose tolerance test (OGTT) and the risk of postpartum diabetes in South Asian women diagnosed with gestational diabetes (GDM). Methods: This analysis was conducted on participants from the Lifestyle Intervention […] ➡️➡️➡️

24-Hour Blood Pressure Variability Via Ambulatory Monitoring and Risk for Probable Dementia in the SPRINT Trial ABSTRACT Blood pressure variability is a risk factor for dementia, even when mean blood pressure levels are rigorously controlled. This study aimed to investigate the effect of ambulatory blood pressure variability on cognitive outcomes under intensive vs standard blood […] ➡️➡️➡️

Study Title: Demonstrating the effectiveness of intra-articular prolotherapy combined with peri-articular perineural injection in knee osteoarthritis: a randomized controlled trial Summary This study compared the effectiveness of different treatments for knee osteoarthritis (KOA). It involved 60 patients aged 48-80 with grade 2 or 3 KOA. Patients were divided into three groups and received different treatments. […] ➡️➡️➡️

Results of Haploidentical Hematopoietic Cell Transplantation for Adult Acute Myeloid Leukemia Study Overview A multicenter, randomized, phase 3 trial assessed the efficacy and safety of haplo-cord HCT in AML patients. A total of 268 eligible patients aged 18-60 years were randomly allocated to receive haplo-cord HCT or haplo-HCT. Main Findings The 3-year overall survival (OS) […] ➡️➡️➡️

Study Title: Trauma Exposure Among Individuals in Medication Treatment for Opioid Use Disorder Background Little is known about the lifetime trauma exposure of individuals in medication treatment for opioid use disorder (MOUD). A recent study examined the prevalence of lifetime trauma and differences based on gender, PTSD status, and chronic pain. Methods A cross-sectional study […] ➡️➡️➡️

Assessment of Safety in Diagnosing Interstitial Lung Disease Rationale and Objectives Bleeding is a common complication of transbronchial lung cryobiopsy (TBLC). This study aimed to determine if pre-placing a bronchial balloon during TBLC for diagnosing interstitial lung disease (ILD) is safer and more effective in preventing bleeding. Materials and Methods Patient with suspected ILD were […] ➡️➡️➡️

The Effect of Fermented Soy Beverage on Localized Prostate Cancer Patients Background Fermented soy products have shown to have inhibitory effects on prostate cancer. We evaluated the effect of a fermented soy beverage (Q-Can®) on men with localized prostate cancer prior to radical prostatectomy. Methods We conducted a placebo-controlled, double-blind randomized trial of Q-Can®. Patients […] ➡️➡️➡️

Semaglutide combined with empagliflozin vs. monotherapy for non-alcoholic fatty liver disease in type 2 diabetes: Study protocol for a randomized clinical trial Practical Solutions and Value Nonalcoholic fatty liver disease (NAFLD) is closely linked to type 2 diabetes mellitus (T2DM). This clinical trial aims to compare the effectiveness and safety of combining semaglutide and empagliflozin […] ➡️➡️➡️

Bleaching Efficacy of In-Office Dental Bleaching Objective This study aimed to compare the effectiveness and side effects of different in-office dental bleaching application protocols. Methods 165 participants underwent bleaching with a 35% hydrogen peroxide gel using three different protocols. Color change, tooth sensitivity, gingival irritation, self-perception, and oral health impact were evaluated. Results All protocols […] ➡️➡️➡️

Effects of NBI-1065845 on Drug Interactions in Healthy Adults Study Overview This study looked at the impact of NBI-1065845, a potential treatment for major depressive disorder, on the metabolism of midazolam and ethinyl estradiol-levonorgestrel in healthy adults. The results provide important insights into potential drug interactions. Key Findings After multiple doses of NBI-1065845, it was […] ➡️➡️➡️

Feasibility and Efficacy of Endoscopy with Blue Laser Imaging for Detecting and Diagnosing Cardia Polyps Key Findings from the Study: Detection rate of cardia polyps was higher with Blue Laser Imaging (BLI) compared to white-light imaging (WLI) Lower rate of overlooked lesions with BLI compared to WLI Diagnostic coincidence rate between magnifying BLI and histopathology […] ➡️➡️➡️