Clinical trials

“`html Disparities in Cancer Clinical Trials Enrollment in Canada A recent study examined the enrollment of new cancer patients in clinical trials at a large Canadian cancer center from 2006 to 2019. The study aimed to identify any disparities in enrollment and their potential impact on treatment access and outcomes. Key Findings: Overall, only 11.2% […] ➡️➡️➡️

“`html Summary of Recent Clinical Advances in Extraesophageal Reflux (EER) Management Purpose of Review: The study discusses the increasing challenges faced by clinicians in dealing with symptoms and complications related to extraesophageal reflux (EER) and highlights the latest clinical advances in understanding its causes, testing, and treatments for upper and lower airway issues. Recent Findings: […] ➡️➡️➡️

“`html Summary of Clinical Trial Report Background Neovascular age-related macular degeneration (nAMD) treatments require long-term follow-up of disease activity, which can be burdensome for patients and caregivers. Home-monitoring could alleviate this burden and free up clinic capacity. Objective The study aimed to assess the effectiveness of 3 vision home-monitoring tests in detecting active nAMD compared […] ➡️➡️➡️

Clinical Trial Report Reducing Quetiapine Use in Patients with Dementia Study Objective: To determine if warning letters to high prescribers of quetiapine can reduce its use among patients with dementia and to assess the impact on patients’ health outcomes. Key Findings: The intervention successfully reduced quetiapine use among both nursing home and community-dwelling patients with […] ➡️➡️➡️

Recombinant Zoster Vaccine (RZV) Study Study on Recombinant Zoster Vaccine (RZV) Background and Objective Researchers aimed to find out if the RZV vaccine could reduce the severity of herpes zoster cases in adults. Methods The study analyzed data from three clinical trials to compare the impact of RZV on the quality of life for vaccinated […] ➡️➡️➡️

“`html Study on Small Kidney Tumors Purpose To see if a new imaging technique, diffusion-relaxation correlation spectroscopic imaging (DR-CSI), can help identify different types and grades of small kidney tumors. Materials and Methods 61 patients with small kidney tumors were included in the study. MRI scans were analyzed using DR-CSI and apparent diffusion coefficient (ADC) […] ➡️➡️➡️

“`html Study Overview A recent clinical trial investigated the effects of synbiotics (probiotics and inulin prebiotics) on patients with pancreatic ductal adenocarcinoma (PDAC) to improve their immune response and reduce postoperative complications. The study compared the combined use of synbiotics versus probiotics alone on 90 PDAC patients. Key Findings The synbiotics group showed significant increase […] ➡️➡️➡️

“`html Enhanced Treatment for Relapsed T-lymphoblastic Leukemia/Lymphoma Patients with relapsed or refractory T-lymphoblastic leukemia/lymphoma (T-ALL/LBL) often face limited treatment options. A new study evaluated a combination therapy using daratumumab (Dara) and venetoclax (Ven) with aclarubicin, cytarabine, granulocyte colony-stimulating factor, and etoposide (CAGE) for these patients. Key Findings: The combined therapy showed a promising remission rate […] ➡️➡️➡️

Food and Gastrointestinal Symptoms in Irritable Bowel Syndrome (IBS) Solving the mystery of food triggers for IBS symptoms Key Points: Various dietary strategies aim to manage IBS symptoms. Study collected food intake and symptom diaries using a smartphone app. 70% of survey respondents had IBS according to Rome IV criteria. Strong associations found for certain […] ➡️➡️➡️

“`html Exercise Training for Hepatocellular Carcinoma Patients: A Systematic Review Background and Aim Patients with hepatocellular carcinoma (HCC) often experience reduced muscle mass and physical function, leading to higher health risks. This review aimed to assess the impact of exercise training programs on muscle mass and physical function in HCC patients. Methods Systematic search in […] ➡️➡️➡️

“`html Study Summary The study aimed to investigate the effectiveness and safety of using a combination of imaging techniques in treating wake-up stroke (WUS) patients. Methods Patients with WUS and specific imaging characteristics underwent either endovascular thrombectomy plus medical therapy or medical therapy alone. Functional outcomes were assessed using the modified Rankin scale (mRs) at […] ➡️➡️➡️

“`html Study Overview This study aimed to assess the impact of subthreshold micropulse laser (SML) in combination with anti-vascular endothelial growth factor (anti-VEGF) therapy for diabetic macular edema (DME). Research Methods Reviewed eight studies involving 493 eyes Four were randomized controlled trials and four were retrospective studies Utilized meta-analysis to analyze best-corrected visual acuity (BCVA), […] ➡️➡️➡️

“`html Practical Solutions for Mental Health Care in Nigerian Prisons Researchers developed strategies to improve mental health care in Nigerian prisons with limited resources. These strategies aimed to provide assessments, identification, and care for inmates and former inmates with mental illness. Over the study period, 74 individuals, mostly males with an average age of 33.25 […] ➡️➡️➡️

Background Colorectal cancer (CRC) rates are high among rural residents and Medicaid enrollees. Objectives To address these disparities, a modified community engagement approach called Boot Camp Translation (BCT) was used to inform messaging about CRC outreach and a mailed fecal immunochemical test program. Methods Eligible rural patients and clinic staff participated in a virtual BCT […] ➡️➡️➡️

“`html Practical Solutions and Value in CD19-Directed Therapy for DLBCL Overview Several treatment options are available for patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL). These options include monoclonal antibody therapy, antibody-drug conjugate therapy, and chimeric antigen receptor T-cell therapy (CAR-T). Challenges Assessing CD19 expression levels and determining the best treatment sequencing strategies […] ➡️➡️➡️

Comparing HIV Screening Strategies in Emergency Departments A recent study evaluated different HIV screening strategies in emergency departments to determine their cost-effectiveness and programmatic costs. Key Findings: The study compared nontargeted and two forms of targeted opt-out HIV screening in emergency departments. Results showed that nontargeted screening incurred higher costs due to an increased number […] ➡️➡️➡️

“`html Summary of Clinical Trial Findings Background Regulatory guidance for Crohn’s disease trials suggests using coprimary efficacy end points to evaluate symptoms and mucosal inflammation. This study aimed to assess the effectiveness of commonly used disease activity assessments alone and in combination. Methods Endoscopic and clinical data from 129 participants in the Study of Biologic […] ➡️➡️➡️

“`html Study Summary The study investigated the use of prebiotics and probiotics (called synbiotics when combined) to improve symptoms associated with autism spectrum disorder (ASD) in 296 children and adults diagnosed with ASD compared to 123 age-matched neurotypical controls. The study found that precision synbiotic supplementation led to improvements in gastrointestinal and ASD-related symptoms. Key […] ➡️➡️➡️

“`html Study Summary Background Recent evidence suggests a link between diabetes and increased risk of liver cancer, especially in Asian populations. Study Design A total of 968,738 adults from 20 different Asian cohort studies were analyzed to investigate the association between diabetes at baseline and the incidence and mortality of liver cancer. The analysis used […] ➡️➡️➡️

“`html Mantle Cell Lymphoma Treatment Patterns and Efficacy Key Findings: 536 patients with mantle cell lymphoma (MCL) were studied Front-line treatments included high-dose cytarabine, bendamustine, and anthracyclines Median progression-free survival (PFS) for all patients was 45 months Second-line treatments varied, with bendamustine-based regimen being the most common Median second-line PFS was little over 1 year […] ➡️➡️➡️