Clinical trials

Background The ongoing conflict in Ukraine has increased stress-related issues like anxiety and depression among veterans. This situation requires effective mental health support, but traditional resources are often limited. As a result, we are exploring new therapies. Objective This study evaluates how well immersive 360° video-based Virtual Reality (VR) therapy works when added to standard […] ➡️➡️➡️

Study Overview This study looked at using a combination of sintilimab (an anti-PD-1 antibody) and chemotherapy as a treatment before surgery for patients with resectable esophageal squamous cell carcinoma (ESCC). The goal was to see how effective and safe this treatment is. Study Details In this phase II study, patients diagnosed with resectable ESCC were […] ➡️➡️➡️

Study Overview A recent study in New Zealand investigated how providing electricity vouchers could improve health outcomes for older adults with Chronic Obstructive Pulmonary Disease (COPD). The aim was to see if warmer homes during winter could lead to fewer health problems for these patients. Key Findings Despite some increase in electricity use among participants, […] ➡️➡️➡️

Objective This study looked at how dexmedetomidine affects sleep quality after intestinal surgery in older patients. Methods We studied 112 older patients, dividing them into two groups. One group received saline (Group A), and the other received dexmedetomidine (Group B). We measured sleep quality before surgery and on days 1, 3, 7, and 30 after […] ➡️➡️➡️

Introduction Cerebrospinal fluid Aβ42 may indicate brain issues and is linked to delirium. This study looks at how changes in blood Aβ42 levels after surgery relate to the risk of delirium in older patients. Methods This study analyzed data from a trial comparing acupuncture to standard care for preventing delirium in patients undergoing major abdominal […] ➡️➡️➡️

Background L-glutamine and linoleic acid (LA) can help reduce skin inflammation, but there haven’t been many studies on using them together because they behave differently. Aims This study looked at how glutamine linoleate vesicles (QLAsomes) affect skin irritation by examining their effects on skin proteins related to sensitization, bacterial growth, and their ability to relieve […] ➡️➡️➡️

Summary of Research Findings Physical inactivity can harm blood sugar control, but exercise can help. This study looked at whether using electrical muscle stimulation (EMS) with or without blood flow restriction (BFR) could help maintain blood sugar control and physical function during a week of reduced activity. Study Overview Thirty-two participants reduced their daily steps […] ➡️➡️➡️

Background Osteoporosis weakens bones and increases the risk of fractures. Along with taking nutritional supplements, exercise can help protect bone health. This study looked at how 16 weeks of high-intensity interval training (HIIT) and vitamin D supplements affect bone mineral density (BMD) in women with osteoporosis. Study Overview The research was designed as a randomized […] ➡️➡️➡️

Study Overview This study looked at how light to moderate aerobic exercise affects bone health in postmenopausal women who have low bone density (osteopenia). Purpose of the Study We wanted to see if exercise could improve bone mineral density (BMD) and how it affects markers that show bone formation and breakdown. The study included women […] ➡️➡️➡️

Study Overview This study evaluated how an interactive avatar application can help patients with Acute Coronary Syndrome (ACS) improve their self-care and recognize heart attack symptoms. Study Design A total of 78 ACS patients participated in a randomized controlled trial. They were divided into two groups: Intervention Group: Received standard education plus training with the […] ➡️➡️➡️

Study Overview This study looked at how effective two laser treatments—laser-assisted new attachment procedure (LANAP) and low-level laser therapy (LLLT)—are when used with traditional cleaning methods for gum disease (scaling and root planing or SRP). Study Design The research involved 68 patients with gum disease. They were split into three groups: Group 1: Received only […] ➡️➡️➡️

Clinical Study Overview This study focused on how effective different strengths of hydrogen peroxide (HP) are for in-office dental bleaching, and how they affect tooth sensitivity and patients’ quality of life. Study Details The trial included 54 participants who received bleaching treatments using three different concentrations of hydrogen peroxide: 18%, 25%, and 40%. The following […] ➡️➡️➡️

Background Finding patients with inherited colorectal cancer (CRC) can greatly help in managing their health. However, many people hesitate to get genetic testing for CRC, leading to low participation rates. As genetic testing becomes more common, we need better ways to help people make informed choices and increase the number of at-risk individuals who get […] ➡️➡️➡️

Background New care models that combine technology can help manage the increasing needs of older adults. However, how effective they really are is still unclear. Objective This study aimed to see how well a new care model, called SMART, could improve the quality of life for older adults living at home. Methods In this study, […] ➡️➡️➡️

Introduction More patients with metastatic colorectal cancer (mCRC) are now showing no signs of disease after treatment. However, current guidelines don’t clearly recommend ongoing treatment for these patients. Capecitabine metronomic chemotherapy is a promising option due to its effectiveness and low side effects, yet no randomized controlled trials (RCTs) have been done on this approach. […] ➡️➡️➡️

Background Postpartum depression (PPD) can affect up to 1 in 5 new parents, leading to more episodes of depression in the future. This study explored whether a one-day online workshop using cognitive behavioral therapy (CBT) could help prevent PPD. Methods This trial involved pregnant individuals at 28-38 weeks who were at high risk for PPD […] ➡️➡️➡️

Importance of Clinical Trials in Cancer Treatment Historically, less than 10% of adults with cancer participate in clinical trials, even though these trials can offer new treatment options. Study Objective This study aimed to see if informing oncologists about specific clinical trials, identified by artificial intelligence (AI), would increase participation when patients’ cancer worsened. Study […] ➡️➡️➡️

Clinical Trial Overview This clinical trial studied the effects of different in-office tooth bleaching gels on tooth sensitivity, gum irritation, and overall patient satisfaction. Study Design 160 participants were divided into two groups of 80. Each group used a different bleaching gel: Whiteness HP Maxx (acidic, unstable pH) Whiteness HP Automixx Plus (neutral, stable pH) […] ➡️➡️➡️

Understanding the Organic Halo Effect This study looks at how organic food labels affect people’s views on calorie content and how often they should eat different types of food. It has been found that organic labels may make foods seem healthier, but the impact varies based on whether the food is high or low in […] ➡️➡️➡️

AIM This study looks at how adding stretching of the hamstring muscles affects pain and mouth opening in people with jaw pain (TMD) when combined with standard treatments like ultrasound therapy. MATERIALS AND METHODS We studied 56 participants aged 18 to 35 years with TMD, randomly dividing them into two groups. The first group (Experimental […] ➡️➡️➡️