Clinical trials

Understanding Primary Axillary Hyperhidrosis Primary axillary hyperhidrosis (PAH) is a condition where individuals experience excessive sweating in their underarms. This can be challenging and affect daily life. Treatment Options The FDA has approved onabotulinum toxin A (OnaBTX-A), commonly known as Botox®, for treating severe PAH. Recent studies suggest that letibotulinum toxin A (LetiBTX-A) may also […] ➡️➡️➡️

Introduction Atrophic acne scarring is a common issue that many people face. Various treatments exist, but combining them often leads to better results. This study compares two treatments: topical insulin and platelet-rich plasma (PRP) used alongside fractional CO2 laser therapy. Study Overview The study involved 30 patients with atrophic acne scars. Each patient received four […] ➡️➡️➡️

Understanding the Study on Post-Acne Erythema Post-acne erythema (PAE) is a common issue after acne treatment, causing emotional distress and social challenges for many individuals. This study explores the effectiveness of combining Intense Pulsed Light (IPL) therapy with intradermal tranexamic acid (TXA) injections to reduce PAE. Study Overview In this trial, 33 patients aged 16 […] ➡️➡️➡️

Purpose This study examines how women with metastatic breast cancer (MBC) use digital mental health interventions (DMHI) to improve their access to support. It focuses on a specific program called Finding My Way-Advanced (FMW-A), which offers personalized resources for these women. Methods Twenty women with MBC participated in interviews after using either the FMW-A program […] ➡️➡️➡️

Background Dual antiplatelet therapy is commonly used for patients with acute coronary syndrome (ACS). However, there is uncertainty about the best treatment option in North America. This study compares the effectiveness and safety of two medications: acetylsalicylic acid (ASA) combined with ticagrelor versus ASA with clopidogrel in ACS patients. Study Overview This was a practical, […] ➡️➡️➡️

Background Family caregivers of individuals with dementia often experience mental health challenges. Acceptance and Commitment Therapy (ACT) is a therapy that may help improve their mental health. This study explored how effective a videoconference-delivered ACT program is for these caregivers. Objective The goal of this pilot study was to see if a 10-week videoconference ACT […] ➡️➡️➡️

Background Stress can be a significant issue for older adults with mild cognitive impairment (MCI). Mindfulness-based programs may help reduce this stress. Objective This study aimed to evaluate how effective a mindfulness program called M-bCCDT is in reducing perceived stress and improving health outcomes for older adults with MCI. Study Design We conducted a randomized […] ➡️➡️➡️

Study Overview This study compares the effectiveness of two treatments for muscle pain in the calf: a massage gun and a myofascial release technique. Both methods aim to relieve pain caused by trigger points in the muscles. Purpose Trigger points can lead to muscle cramps, fatigue, and weakness. This study seeks to determine which treatment […] ➡️➡️➡️

Understanding Group Interpersonal Psychotherapy for Adolescents with Non-Suicidal Self-Injury Non-suicidal self-injury (NSSI) is a serious issue among adolescents. A recent study explored how effective Group Interpersonal Psychotherapy (G-IPT) is when combined with standard treatment (TAU) compared to standard treatment alone. Study Overview This research took place in a psychiatric outpatient clinic in Hubei Province, China, […] ➡️➡️➡️

Background Postnatal depression is more common among British South Asian women than white women in the UK. Cognitive-behavioral therapy is known to be effective, but there is limited evidence on its use in different ethnic groups. Objectives The study aimed to evaluate the effectiveness and cost of a culturally adapted group therapy called the Positive […] ➡️➡️➡️

Hepatitis C Treatment for Vulnerable Populations Introduction Hepatitis C virus (HCV) can be effectively treated with new medications, but many vulnerable groups struggle to access this treatment. Objective This study aimed to evaluate how well specific treatment plans work for vulnerable populations in Austin, Texas. Methods We enrolled patients diagnosed with chronic hepatitis C and […] ➡️➡️➡️

Overview of the Clinical Trial The study aimed to compare two methods of monitoring children with septic shock. One group used advanced monitoring with electrocardiometry, while the other relied only on standard clinical monitoring. Key Findings Children in the standard monitoring group (Group A) needed more fluid in the first 6 hours (30 mL/kg) compared […] ➡️➡️➡️

Introduction Managing anticoagulant prescriptions is vital for treating venous thromboembolism (VTE). Clinical decision support systems (CDSS) help healthcare professionals make better decisions. Objective The goal was to create and evaluate a mobile app-based CDSS for managing VTE. Methods A randomized controlled trial involved participants aged 20 and older, including medical students and residents. They were […] ➡️➡️➡️

Background Bronchoscopy is a common medical procedure used to examine the lungs, but it can cause anxiety and discomfort for patients. This study aimed to see if playing music during the procedure could help reduce anxiety levels. Methods We conducted a study in two university hospitals with 136 patients. They were divided into two groups: […] ➡️➡️➡️

Background In sub-Saharan Africa, many fishermen, who often move around a lot, do not get tested for HIV or seek treatment. This study looked at whether a new approach using social networks could help these fishermen in Kenya get tested and linked to HIV prevention and treatment services. Study Overview The study took place in […] ➡️➡️➡️

Background and Aims Late-evening snacks can help patients with liver cirrhosis, but there is no clear agreement on what these snacks should contain. This study compared two types of snacks: one high in protein and the other containing branched-chain amino acids (BCAA). Methods In this study, 32 Vietnamese patients with liver cirrhosis participated. They were […] ➡️➡️➡️

Study Overview This study examined how different doses of dobutamine affect heart muscle health in patients with ischemic cardiomyopathy (ICM) and the role of β-blockers in improving diagnosis. Study Details A total of 189 patients with ICM participated in the study. They were divided into three groups based on the dobutamine dose: Low-dose group (10 […] ➡️➡️➡️

Background Invasive fungal infections (IFIs), especially Candida infections, can be very serious for patients with acute leukemia. Fluconazole is commonly used to prevent these infections, but the best dosage is still unclear. Study Purpose This study looked at how effective low-dose fluconazole is in preventing Candida infections in patients with acute leukemia undergoing intensive chemotherapy. […] ➡️➡️➡️

Study Overview This study focused on major cardiovascular events (MACE) that can occur after a procedure called percutaneous coronary intervention (PCI). These events are a leading cause of death for patients. The goal was to see if combining two medications, ezetimibe and atorvastatin, would be more effective than using atorvastatin alone in reducing these events. […] ➡️➡️➡️

Background There are currently no established methods for including trauma-informed care in prenatal services. This study looks at what pregnant individuals prefer regarding their prenatal care, providers, and how trauma is addressed. Methods This research was part of a larger clinical trial and took place in a health center and clinic in a big city. […] ➡️➡️➡️