Clinical trials

Overview of JS005 Clinical Trials JS005 is a new medication designed to treat moderate to severe plaque psoriasis. It works by targeting a specific protein in the body called IL-17A. Two studies were conducted to test its safety and effectiveness. Study Details Phase Ia Study: This initial study involved 40 healthy adults. It was designed […] ➡️➡️➡️

Background Intractable vascular anomalies (VAs) can cause serious symptoms and have a poor outlook. New treatment options are necessary. This study tested sirolimus, a medication, to see if it could help treat VAs. Study Details The study was conducted at four hospitals in Japan. Patients with VAs took sirolimus daily. The goal was to maintain […] ➡️➡️➡️

Background Mothers of low birth weight or preterm infants often experience more postpartum depression compared to those with full-term infants. Providing mental support in neonatal intensive care units (NICUs) is essential. Objective This study aimed to see if a psychological intervention using the Neonatal Behavioral Assessment Scale (NBAS) could help reduce depressive symptoms in mothers […] ➡️➡️➡️

Improving Colposcopy for Postmenopausal Women Postmenopausal women often face challenges during colposcopy, including: Easy bleeding due to thinning vaginal tissue Poor visibility during the procedure Lower sensitivity of colposcopy Study Overview To address these issues, we conducted a study to evaluate the effectiveness of a compound sea-buckthorn oil suppository as a pretreatment for colposcopy. The […] ➡️➡️➡️

Introduction Cervical cancer is a major health issue in Singapore, with only 43% of women getting screened, far below the 70% target. In 2019, HPV DNA testing was added to the screening program, but many women avoid it due to feelings of embarrassment, privacy concerns, and discomfort with clinician sampling. Self-sampling for HPV DNA testing […] ➡️➡️➡️

Predicting Cognitive Decline in Alzheimer’s Disease Trials Background and Purpose In Alzheimer’s disease (AD) treatment trials, about 40% of participants do not show any cognitive decline after 80 weeks. By identifying and excluding these individuals, we can enhance the effectiveness of treatment impact detection. Our goal was to create machine learning models that can identify […] ➡️➡️➡️

Clinical Trial Overview This clinical trial focused on a method called postural therapy for women with breech presentation, where the baby is positioned feet-first in the womb. The study took place in Kawasaki, Japan, and included 200 pregnant women between 28 and 30 weeks of gestation. Study Method Participants were divided into two groups: one […] ➡️➡️➡️

Home Phototherapy for Neonatal Jaundice Home phototherapy is a recommended option for treating neonatal jaundice in healthy full-term infants. It allows for treatment at home instead of the hospital, which can be more convenient for families. Measuring Bilirubin Levels To ensure the treatment is effective, bilirubin levels need to be monitored. A device that measures […] ➡️➡️➡️

Understanding Ultrasound Therapy for Jaw Pain Background Temporomandibular disorders (TMD) that cause muscle pain (TMD-M) are common issues for patients. To treat these disorders effectively, it is important to understand their complex causes. Study Overview This study involved 80 patients with TMD-M. They were divided into two groups: one received continuous ultrasound therapy, and the […] ➡️➡️➡️

Impact of Dietary Sodium and Fructose on Blood Pressure Research has shown that eating more sodium is connected to high blood pressure (BP). However, many young adults do not experience higher BP with increased sodium intake. This study aimed to see how fructose, when combined with sodium, affects BP and how the kidneys manage sodium. […] ➡️➡️➡️

Objective The PaCUDAHL clinical trial tested a device for women to collect samples for HPV testing at home, provided by their family doctor. This study looked at whether the presence of doctors participating in the trial affected the behavior of women regarding cervical cancer screening. Results We studied 332 doctors and 70,983 women aged 25-65 […] ➡️➡️➡️

Impact of Ultra-Processed Food on Mental Health in Older Adults This study explored how eating ultra-processed foods (UPF) affects depression and mental health in older adults living in the community. Previous research suggested a link between UPF and depression, but this study specifically focused on older individuals. Study Overview The research involved older adults aged […] ➡️➡️➡️

“`html Background In Taiwan, patients with psychiatric conditions often face unfair judgments that affect their ability to make healthcare decisions. These judgments may arise from concerns about their cognitive abilities, emotional stability, and communication skills. As a result, their independence in making healthcare choices is often compromised. There is a significant lack of understanding and […] ➡️➡️➡️

Objective This study aimed to find out how using a cognitive behavioral therapy (CBT) self-help app can help reduce depression in young people at risk. Method In a recent trial, young people aged 16-22 who were likely to develop depression were divided into groups. They used different apps: one for self-monitoring, one for self-monitoring plus […] ➡️➡️➡️

Background In-person nutrition and exercise programs help improve health for people with chronic diseases. However, we need to understand how well online programs work, especially with different levels of support. Objective This study evaluates a fully online nutrition and exercise program from start to finish. Methods We conducted a controlled trial using the Heal-Me platform. […] ➡️➡️➡️

Background Fluid loading is a common treatment for major bleeding, but it can sometimes lead to too much fluid in the body. We looked at different ways to replace fluids during major surgeries and how well certain tests can identify low blood volume. Methods In our study, we randomly assigned 42 patients to receive one […] ➡️➡️➡️

Background About half of ovarian cancer survivors experience a strong fear of their cancer coming back, which makes it hard for them to cope with life after treatment. This study looked at the iConquerFear program, an online tool designed to help these survivors manage their fears. Study Details Between October and December 2022, 62 women […] ➡️➡️➡️

Introduction Atrial fibrillation is a common heart rhythm disorder that is expected to rise in the coming years. While lifestyle changes and managing risk factors are important for treatment, there is limited research on how exercise impacts patients with this condition. About the Study The Norwegian Exercise in Atrial Fibrillation Trial (NEXAF) aims to explore […] ➡️➡️➡️

Background Modern technology has greatly improved how students learn and develop their skills. Study Overview A six-month study was conducted at Khyber College of Dentistry in Peshawar. The goal was to compare traditional learning methods with YouTube learning to see which better improved students’ ability to diagnose using lateral cephalometry. Results Seventy-four students participated, with […] ➡️➡️➡️

Overview of the EARLIER Trial The EARLIER trial studied how eplerenone, a medication, affects patients with acute heart failure (HF) who also have diabetes and/or chronic kidney disease (CKD). Key Findings In the trial, 300 patients were treated with either eplerenone or a placebo for six months. Here are the main points: 39% of the […] ➡️➡️➡️