Clinical trials
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffects of HIV Self-Testing on Testing Promotion and Risk Behavior Reduction Among Transgender Women in China: Randomized Controlled Trial
Effects of HIV Self-Testing on Transgender Women in China Study Overview This study investigates how HIV self-testing (HIVST) impacts HIV testing behavior among transgender women in China. Key Objectives Evaluate changes in HIV testing behavior. Assess the frequency of condomless sex. Examine the number of sexual partners. Methodology Transgender women from two cities in China […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseA Tailored Postpartum eHealth Physical Activity Intervention for Individuals at High Risk of Postpartum Depression-the POstpartum Wellness Study (POW): Protocol and Data Overview for a Randomized Controlled Trial
A Tailored Postpartum eHealth Physical Activity Intervention for Individuals at High Risk of Postpartum Depression-the POstpartum Wellness Study (POW) Overview This study focuses on postpartum depression (PPD), which can significantly affect both parents and their children. Traditional PPD prevention methods require a lot of healthcare resources. We need effective solutions that don’t add to this […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseSound Localization in Single-Sided Deafness; Outcomes of a Randomized Controlled Trial on the Comparison Between Cochlear Implantation, Bone Conduction Devices, and Contralateral Routing of Signals Hearing Aids
Study on Sound Localization in Single-Sided Deafness Overview This study compares different treatments for single-sided deafness (SSD) to see which one helps patients locate sounds better over time. It looks at cochlear implants (CI), bone conduction devices (BCD), contralateral routing of signals (CROS) hearing aids, and no treatment. Key Findings Participants: 120 SSD patients were […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseRandomized Controlled Feasibility Trial of Late 8-Hour Time-Restricted Eating for Adolescents With Type 2 Diabetes
Randomized Controlled Feasibility Trial of Late 8-Hour Time-Restricted Eating for Adolescents With Type 2 Diabetes Background No previous studies have looked into how late time-restricted eating (lTRE) impacts blood sugar control or body composition in adolescents with type 2 diabetes (T2D). Objective The goal of this study was to see if lTRE is feasible, acceptable, […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseThe effect of tranexamic acid on postpartum bleeding in women with moderate and severe anaemia (WOMAN-2): an international, randomised, double-blind, placebo-controlled trial
The Effect of Tranexamic Acid on Postpartum Bleeding in Women with Anaemia Study Overview This study, known as WOMAN-2, looked at whether tranexamic acid can help prevent postpartum bleeding in women with moderate or severe anaemia after childbirth. Key Details Type of Study: International, randomised, double-blind, placebo-controlled trial. Location: Conducted in 34 hospitals across Nigeria, […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseAssessment of the impact of combining butylphthalide and atorvastatin on neurological function, quality of life and vascular endothelial function in individuals diagnosed with acute cerebral infarction
Impact of Butylphthalide and Atorvastatin on Acute Cerebral Infarction Study Overview Acute cerebral infarction is a serious health issue, and finding effective treatments is essential. This study evaluated how combining Butylphthalide and Atorvastatin affects neurological function, quality of life, and blood vessel health in 124 patients with acute cerebral infarction. Key Findings Participants were divided […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseMicrobiota Transplantation in Individuals with Type 2 Diabetes and a High Degree of Insulin Resistance
Microbiota Transplantation in Type 2 Diabetes Patients Study Overview This study aimed to evaluate the effects of fecal microbiota transplantation (FMT) from healthy lean donors in patients with type 2 diabetes (T2D). It was a phase II clinical trial involving 21 participants (12 men and 9 women) with a mean age of 62.5 years and […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffect of Time-Restricted Eating on Circulating Levels of IGF1 and Its Binding Proteins in Obesity: An Exploratory Analysis of a Randomized Controlled Trial
Effect of Time-Restricted Eating on IGF1 Levels in Obesity Study Overview This study explored how time-restricted eating (TRE) affects levels of IGF1 and its binding proteins in people with obesity. It also looked at how these effects relate to weight loss and body composition changes. Objective The main goal was to see how TRE impacts […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseOnline and Face-to-Face Mat Pilates Training for Long COVID-19 Patients: A Randomized Controlled Trial on Health Outcomes
Online and Face-to-Face Mat Pilates Training for Long COVID-19 Patients A Study on Health Outcomes This study looked at how online and in-person Mat Pilates training affects adults with long COVID symptoms, particularly fatigue. A total of 49 patients, averaging 52 years old, were divided into three groups: Online Mat Pilates training (16 patients) Face-to-face […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseA smartphone app for preschool wheezing and reliability of medical history collection
A Smartphone App for Managing Preschool Wheezing Study Overview This study explores how a smartphone app can help manage wheezing in preschool children. It also examines how reliable the medical history collected during doctor visits is. Key Objectives To test the feasibility of a smartphone app for preschool wheezing management. To evaluate the reliability of […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
A prospective multicenter randomized controlled trial on artificial intelligence assisted colonoscopy for enhanced polyp detection
A Study on AI-Assisted Colonoscopy for Better Polyp Detection Overview Detecting and removing colon polyps during colonoscopy is vital for preventing colorectal cancer. This study focused on creating an AI program to improve polyp detection using the RetinaNet algorithm. Study Details The AI program was developed using a large dataset that was anonymized and split […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseComparison of zuberitamab plus CHOP versus rituximab plus CHOP for the treatment of drug-naive patients diagnosed with CD20-positive diffuse large B-cell lymphoma: a phase 3 trial
Comparison of Zuberitamab Plus CHOP vs. Rituximab Plus CHOP for DLBCL Treatment Study Overview This study aimed to compare the effectiveness and safety of zuberitamab plus CHOP against rituximab plus CHOP in patients with untreated CD20-positive diffuse large B-cell lymphoma (DLBCL). Methods Patients were randomly assigned to receive six cycles of either zuberitamab or rituximab […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Over-the-Counter Hearing Aids Versus Traditional Hearing Aids in Patients With Mild-to-Moderate Hearing Loss: Protocol for a Noninferiority Randomized Controlled Trial
Over-the-Counter Hearing Aids vs. Traditional Hearing Aids Background Hearing loss (HL) is becoming more common, affecting about 5% of people worldwide. This number could reach 7 million by 2050. Traditional hearing aids (HAs) are the main treatment but are often too expensive or carry social stigma. Over-the-counter (OTC) HAs are a new option, but we […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffects of Immersive Virtual Therapy as a Method Supporting the Psychological and Physical Well-Being of Women with a Breast Cancer Diagnosis: A Randomized Controlled Trial
Effects of Virtual Reality Therapy for Women with Breast Cancer Study Overview This study explores how virtual reality (VR) can help improve the mental health, sleep quality, and physical activity of women diagnosed with breast cancer. Key Findings A total of 33 women participated, split into two groups: one receiving VR therapy and the other […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseNatural frequency tree- versus conditional probability formula-based training for medical students’ estimation of screening test predictive values: a randomized controlled trial
Natural Frequency Tree vs. Conditional Probability Training for Medical Students Study Overview Medical students often find it hard to interpret test results, which can result in poor healthcare decisions. This study compares two training methods: Natural Frequency Tree-based Training (NF-TT) and Conditional Probability Formula-based Training (CP-FT). The goal is to see which method helps students […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseCombination of different local anesthetic adjunct for supraclavicular brachial plexus block after arthroscopic shoulder surgery: a prospective randomized controlled trial
Study Overview This study explored how combining different local anesthetics can improve pain relief after arthroscopic shoulder surgery. Background After shoulder surgery, many patients experience acute pain. While supraclavicular brachial plexus block helps manage this pain, its effects don’t last long enough. This study aimed to find out if combining various local anesthetic adjuncts could […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffectiveness of high-frequency vibration, cotton rolls and elastomeric wafers in alleviating debonding pain of orthodontic metal brackets: a randomized clinical trial
Effectiveness of Pain Relief Methods During Orthodontic Debonding Study Overview This study examined how effective different methods are in reducing pain during the removal of orthodontic metal brackets. A total of 144 participants (50 males and 94 females) were divided into four groups: High-Frequency Vibration (V) Cotton Roll (CR) Elastomeric Wafer (EW) Open Mouth (OM) […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Study on the Mechanism of Nd:YAG Laser-Assisted Therapy on the Changes of Subgingival Flora in Periodontitis
Study on Nd:YAG Laser Therapy for Periodontitis Purpose This study looked at how effective Nd:YAG laser therapy is when combined with traditional cleaning methods for patients with severe periodontitis. We focused on its impact on inflammation and bacteria in the mouth. Materials and Methods Fifteen patients with severe periodontitis participated in the study. Their mouths […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Electroacupuncture Protocol for Sensory and Motor Function Recovery After Orthognathic Surgery: a Randomized Clinical Trial
Electroacupuncture for Recovery After Orthognathic Surgery: A Clinical Trial Importance Orthognathic surgery corrects facial deformities but may cause nerve sensitivity issues. Electroacupuncture could help improve sensitivity and motor functions in patients after surgery, yet its use in facial injuries needs more research. Objective This study aims to explore how electroacupuncture affects sensitivity and facial function […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseLow tourniquet pressure has less impact on lower extremity nerve innervation: comparison of different tourniquet pressures used with intraoperative neuromonitoring with a randomized controlled study
Study Overview This study examined how different tourniquet pressures affect nerve activity during foot and ankle surgery. Purpose The goal was to see if lower tourniquet pressure could reduce nerve damage compared to higher pressure during surgery. Methods We included 24 patients aged 18-65 who had foot and ankle surgery. They were randomly assigned to […] ➡️➡️➡️