Clinical trials
-
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phasePreventive effect of prenatal maternal oral probiotic supplementation on neonatal jaundice (POPS Study): A protocol for the randomised double-blind placebo-controlled clinical trial
Preventive Effect of Prenatal Maternal Oral Probiotic Supplementation on Neonatal Jaundice (POPS Study): A Protocol for the Randomised Double-Blind Placebo-Controlled Clinical Trial Abstract Neonatal jaundice is a common and life-threatening health problem in newborns due to an excess of bilirubin. Gut flora may influence bilirubin metabolism, and the infant gut microbiome is often similar to […] ➡️➡️➡️
-
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseComparative study between efficacy of Excimer light with topical Tacrolimus 0.1% versus excimer light with topical Bimatoprost 0.01% in treatment of facial Vitiligo
Comparative Study on Treatment of Facial Vitiligo Published in Arch Dermatol Res. 2024 Jun 8;316(7):350 Loss and absence of melanocytes due to various factors lead to vitiligo, the most common pigmentation disorder. This study aimed to compare the effectiveness and safety of two treatments for facial vitiligo: excimer light with topical tacrolimus ointment 0.1% and […] ➡️➡️➡️
-
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Split face randomized, evaluator blinded study on the effect of multiple subcisions on rolling acne scars
Study on the Effect of Multiple Subcisions on Rolling Acne Scars Summary Acne scarring can greatly impact quality of life. Current treatments have limitations, but the subcision technique shows promise for treating rolling acne scars. This study evaluated the effects of multiple subcision treatments compared to no treatment. Methods Five patients with rolling acne scars […] ➡️➡️➡️
-
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseLong-pulsed nd: YAG laser treatment of nail psoriasis: clinical and ultrasonographic assessment
Clinical Trial Results: Long-pulsed nd: YAG Laser Treatment for Nail Psoriasis Overview Nail psoriasis is a challenging condition associated with significant impact on quality of life. This study aimed to evaluate the effectiveness of long-pulsed 1064 nm Nd: YAG laser treatment for fingernail psoriasis using clinical and ultrasonographic assessments. Key Findings After three monthly treatment […] ➡️➡️➡️
-
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffects of intensive lifestyle changes on the progression of mild cognitive impairment or early dementia due to Alzheimer’s disease: a randomized, controlled clinical trial
Effects of Intensive Lifestyle Changes on Alzheimer’s Disease Progression Background Research suggests that lifestyle factors may impact Alzheimer’s disease (AD). This study is the first of its kind to investigate whether intensive lifestyle changes can positively influence the progression of mild cognitive impairment (MCI) or early dementia due to AD. Methods This phase 2 trial […] ➡️➡️➡️
-
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseDapagliflozin reduces systemic inflammation in patients with type 2 diabetes without known heart failure
Dapagliflozin Reduces Systemic Inflammation in Patients with Type 2 Diabetes Key Findings: Dapagliflozin, a medication for type 2 diabetes, was found to reduce plasma IL-1B and increase ketone levels, indicating a potential anti-inflammatory effect. The drug also showed no change in PBMC mitochondrial respiration, suggesting a positive impact on inflammation. Practical Solutions and Value: This […] ➡️➡️➡️
-
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseDose escalation of tolinapant (ASTX660) in combination with standard radical chemoradiotherapy in cervical cancer : a study protocol for a phase 1b TiTE-CRM clinical trial (CRAIN) in UK secondary care centres
Dose Escalation of Tolinapant in Combination with Chemoradiotherapy for Cervical Cancer Practical Solutions and Value Cervical cancer is a significant health concern, and the standard treatment has limitations. Tolinapant, an IAP antagonist, has shown promise in preclinical studies when combined with cisplatin and radiotherapy. The CRAIN trial aims to assess the safety and effectiveness of […] ➡️➡️➡️
-
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseThe incidence and intensity of postoperative pain and Flare-up following the use of three different intracanal medicaments in teeth with posttreatment apical periodontitis: a randomized clinical trial
Study Summary This clinical trial compared the effects of three different intracanal medicaments on postoperative pain and flare-up in patients with posttreatment apical periodontitis (PTAP) undergoing retreatment. Study Participants 120 patients with single-rooted teeth and single-canal PTAP, without spontaneous pain or swellings, were randomly divided into three groups. Interventions Patients received one of the following […] ➡️➡️➡️
-
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseExploring relationships with food after dietary intervention in patients with colorectal cancer: a qualitative analysis from the Protein Recommendations to Increase Muscle (PRIMe) trial
Exploring Relationships with Food After Dietary Intervention in Patients with Colorectal Cancer: A Qualitative Analysis from the PRIMe Trial Abstract Purpose: Patients with cancer often face nutritional challenges and muscle mass loss. This study aimed to understand how participation in the PRIMe trial affected patients’ relationships with food. Methods: Patients with colorectal cancer participated in […] ➡️➡️➡️
-
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseSaccharomyces boulardii combined with triple therapy alter the microbiota in the eradication of Helicobacter pylori infection
Study Title: Saccharomyces boulardii Combined with Triple Therapy for H. pylori Infection Key Findings: A clinical trial evaluated the effectiveness of combining Saccharomyces boulardii powder with triple therapy for eradicating H. pylori infection in patients with non-ulcer dyspepsia. The study included 144 patients and monitored microbial composition, eradication rates, symptom alleviation, and adverse reactions. Results: […] ➡️➡️➡️
-
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseAdditional copies of 1q negatively impact the outcome of multiple myeloma patients and induce transcriptomic deregulation in malignant plasma cells
Impact of Additional Copies of Chromosome 1 Long Arm in Multiple Myeloma Patients Key Findings: Patients with amplification (Amp1q, ≥4 copies of 1q) or gain (Gain1q, 3 copies of 1q) of chromosome 1 long arm (1q) may experience different outcomes and biology compared to those with normal 1q. Presence of Amp1q significantly hampered median progression-free […] ➡️➡️➡️
-
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseA pharmacist-led interprofessional medication adherence program improved adherence to oral anticancer therapies: The OpTAT randomized controlled trial
OpTAT Trial: Improving Adherence to Oral Anticancer Therapies Summary A pharmacist-led program improved patient adherence to oral anticancer therapies, specifically implementation, among patients with solid cancers. The program included monthly electronic and motivational feedback, educational support, and behavioral components over 12 months. Key Findings Patients in the intervention arm showed consistently higher day-by-day medication implementation […] ➡️➡️➡️
-
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseLung Cancer Screening Before and After a Multifaceted Electronic Health Record Intervention: A Nonrandomized Controlled Trial
Lung Cancer Screening Intervention Trial Key Findings Lung cancer is the deadliest cancer in the US, but early detection through screening improves outcomes. A nonrandomized controlled trial assessed a multifaceted intervention’s impact on identifying and completing recommended lung cancer screening (LCS) services. Study Details The trial involved patients aged 55 to 80 years with a […] ➡️➡️➡️
-
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Subcision with and without suction for acne scars: a split-faced, rater-blinded randomized control trial
Study Results: Subcision with and without Suction for Acne Scars Overview Therapeutic options for acne scars were compared in a randomized control trial. The study aimed to determine the effectiveness of subcision alone versus subcision with suction for treating facial acne scars. Findings The study found that subjects perceived the combination treatment as working more […] ➡️➡️➡️
-
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseSystemic antibiotics for Pseudomonas aeruginosa infection in outpatients with non-hospitalised exacerbations of pre-existing lung diseases: a randomised clinical trial
Systemic Antibiotics for Pseudomonas Aeruginosa Infection in Outpatients with Lung Diseases: Clinical Trial Results Background The study aimed to determine the impact of dual systemic antibiotic therapy on Pseudomonas aeruginosa in outpatients with COPD, non-CF bronchiectasis, or asthma. Methods The trial was conducted at seven respiratory outpatient clinics in Denmark. Outpatients with pre-existing lung diseases […] ➡️➡️➡️
-
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseA study protocol for the modified interactive screening program plus MINDBODYSTRONG© RCT: A mental health resiliency intervention for nurses
Study Protocol: Mental Health Resiliency Intervention for Nurses Background Nurses face high risks of depression, anxiety, burnout, and suicidal ideation, with suicide rates higher than the general population. This trial aims to reduce these risks and improve mental well-being through a combined cognitive-behavioral skills building program and the Modified Interactive Screening Program (mISP). Aims The […] ➡️➡️➡️
-
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
The Effects of Art Therapy and Psychosocial Skills Training on Symptoms and Social Functioning in Patients with Schizophrenia and Their Relatives
The Effects of Art Therapy and Psychosocial Skills Training on Symptoms and Social Functioning in Patients with Schizophrenia and Their Relatives Objective The study aimed to evaluate and compare the effects of art therapy and psychosocial skills training (PSST) in the treatment of schizophrenia. Methods A total of 15 patients diagnosed with schizophrenia and 12 […] ➡️➡️➡️
-
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseA Multicenter randomized comparative study of dementia nursing practice skills development programs for nurses in acute care hospitals: A Comparison of person-centered care and dementia-type-specific programs
Results of Multicenter Study on Dementia Nursing Practice Skills Purpose and Methods The study compared the effectiveness of a person-centered care program and a dementia-type-specific program for nurses in acute-care hospitals across seven locations. The research was conducted from July 2021 to January 2022. Key Findings A total of 158 participants were included, with significant […] ➡️➡️➡️
-
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Efficacy of a Structured Yoga Intervention Integrated with Routine Care versus Exercise on Pulmonary Function and Quality of Life of Asthma Patients: A Randomized Controlled Trial
Efficacy of Yoga Intervention for Asthma Patients Results of a Randomized Controlled Trial A study was conducted to evaluate the effectiveness of a structured yoga intervention integrated with routine care for asthma patients in improving their pulmonary function and quality of life. The study involved adults aged 18 to 60 with mild to moderate asthma. […] ➡️➡️➡️
-
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Two doses of fosaprepitant included prophylactic treatment for the three-day cisplatin-based chemotherapy induced nausea and vomiting
Study on Fosaprepitant for Chemotherapy-Induced Nausea and Vomiting Practical Solutions and Value: Two doses of fosaprepitant were studied for preventing nausea and vomiting caused by three-day cisplatin-based chemotherapy in lung cancer patients. This study aimed to explore the effectiveness and safety of using two doses of fosaprepitant for this purpose. The study involved 204 participants […] ➡️➡️➡️