Clinical trials
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseA Comparative and Prospective Study of Corneal Consumption and Corneal Biomechanics After SMILE and FS-LASIK Performed on the Contralateral Eyes With High Myopic Astigmatism
A Study on Corneal Health After SMILE vs. FS-LASIK Published: Transl Vis Sci Technol. November 4, 2024; 13(11):29. DOI: 10.1167/tvst.13.11.29 Purpose of the Study This study compares how much corneal tissue is used and how the cornea’s mechanics change after two types of eye surgery: small incision lenticule extraction (SMILE) and femtosecond laser-assisted in situ […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseStudy protocol for a randomized controlled trial evaluating the effectiveness of a mother-child intervention model of neurogenic tremor as an add-on to treatment for emotional disorders in adolescents
Study Overview This study focuses on a new approach to help adolescents with emotional disorders by involving their mothers in a therapeutic program. Background Many adolescents face mental health issues, especially after the COVID-19 pandemic, leading to increased anxiety and depression. Traditional treatments like medication and therapy can be expensive and hard to access. Therefore, […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phasePre-radiation Nivolumab plus ipilimumab in patients with newly diagnosed high-grade gliomas
Pre-radiation Nivolumab plus Ipilimumab for High-Grade Gliomas Study Overview This study explores the use of immune checkpoint inhibitors (ICIs) before radiation therapy in patients with newly diagnosed high-grade gliomas. We conducted a phase I trial with patients receiving: Nivolumab: 300 mg every 2 weeks Ipilimumab: 1 mg/kg every 6 weeks Treatment continued until disease progression […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseThe effects of a short exercise bout on executive functions in healthy older adults
The Impact of Short Exercise on Brain Function in Older Adults Study Overview This study investigates how a brief 20-minute session of moderate exercise affects cognitive abilities in healthy older adults. Regular physical activity is known to support brain health, but the effects of short exercise sessions are not fully understood. Key Findings Participants: 48 […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseA randomized clinical trial evaluating Hydralazine’s efficacy in early-stage Alzheimer’s disease: The EHSAN Study
A Randomized Clinical Trial on Hydralazine for Early-Stage Alzheimer’s Disease: The EHSAN Study Overview Alzheimer’s Disease (AD) is a growing global issue with no cure available. Current treatments only help with symptoms. Hydralazine, a medication for high blood pressure, has shown promise in animal studies for protecting brain cells and improving their function. However, we […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
The clinical and microbiological efficacy of a zinc-citrate/hydroxyapatite/potassium-citrate containing toothpaste: a double-blind randomized controlled clinical trial
The Efficacy of a New Toothpaste: A Clinical Trial Overview Study Purpose This study aimed to test the effectiveness of two types of toothpaste, one with added ingredients like zinc-citrate (ZCT), hydroxyapatite (HAP), and potassium-citrate (KCit), and one with only fluoride. We wanted to see how well these toothpastes reduce bacteria, tooth sensitivity, plaque buildup, […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseDigital Homework Support Program for Children and Adolescents With Attention-Deficit/Hyperactivity Disorder: Protocol for a Randomized Controlled Trial
Digital Homework Support Program for Children with ADHD Overview Attention-deficit/hyperactivity disorder (ADHD) affects about 4% to 5% of people. Homework time can be stressful for children with ADHD, leading to anxiety and family stress. Many kids with ADHD struggle more with homework than their peers, which can hurt their academic success. Traditional support methods can […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseApproaches for improvement of ocular surface condition in primary open-angle glaucoma
Improving Eye Health in Glaucoma Patients Study Overview This study looks at how to improve eye surface health in patients with primary open-angle glaucoma (POAG) who also have dry eye syndrome (DES) and meibomian gland dysfunction (MGD). What We Did We included 48 patients with stage II POAG, who were treated with a specific eye […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseAutism Transition to Adulthood Groups (ATAG): protocol for a feasibility RCT of a new peer-group intervention to promote successful transition to adulthood for autistic young people
Autism Transition to Adulthood Groups (ATAG) Overview of a New Study for Autistic Young Adults Study Purpose: This study aims to support autistic young people as they transition to adulthood. It focuses on improving their well-being through a new online peer-group program called ‘Understanding You, Discovering You’ (UYDY). Key Points of the Study: Target Group: […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffect of a Stannous Fluoride Toothpaste Stabilized With Nitrate and Phosphates (SNaP) on Dentin Hypersensitivity: In Vitro Study and Randomized Controlled Trial
Effect of Stannous Fluoride Toothpaste on Dentin Hypersensitivity Background Dentin hypersensitivity is a common dental issue worldwide. This study tested a special toothpaste containing 0.454% stannous fluoride, along with nitrate and phosphates, to see if it could help reduce this sensitivity. Methods We treated human dentin samples with different toothpaste mixtures and checked how well […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseCommunity Versus Facility-Based Services to Improve the Screening of Active Hepatitis C Virus Infection in Cambodia: The ANRS 12384 CAM-C Cluster Randomized Controlled Trial-Protocol for a Mixed Methods Study
Community Versus Facility-Based Services for Hepatitis C Screening in Cambodia Background: Hepatitis C is a major health issue in Cambodia, especially for those over 45 years old, with a prevalence of 5%. Improving access to screening and treatment is essential for eliminating hepatitis C. Objective: This study will compare the effectiveness of community-based screening versus […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Acute severe pain in emergency department: Morphine or low-dose ketamine?
Acute Severe Pain in Emergency Department: Morphine vs. Low-Dose Ketamine Introduction Severe pain is a critical issue that can be dangerous due to its location and potential misdiagnosis. Aim This study aimed to compare the effectiveness of morphine and low-dose ketamine for treating severe pain in the emergency department. Methods We conducted a randomized open […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
New Prospects for Conservative Treatment of Chronic Recurrent Cystitis in Women: Experience with the Drug Superlymph
New Solutions for Treating Chronic Recurrent Cystitis in Women: Experience with Superlymph Introduction Chronic recurrent cystitis is a common and challenging issue in urology. Traditional antimicrobial treatments often fail to provide long-term relief. Aim This study aimed to assess the effectiveness and safety of the drug Superlymph, administered through rectal and vaginal suppositories in two […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Experience with UroBest in patients with acute cystitis
Experience with UroBest in Patients with Acute Cystitis Study Overview AIM: This study aimed to assess how effective and safe UroBest is for treating acute cystitis compared to similar products. Methods The study involved 90 patients aged 18 to 49 with acute cystitis. They were treated at various clinical sites in Russia. All patients received […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseStudy of the pharmacokinetics of extended release sildenafil
Study of the Pharmacokinetics of Extended Release Sildenafil Purpose of the Study The study aimed to compare how the drug Vildegra, approved in Russia, behaves in the body compared to the original drug, Viagra. Materials and Methods The study was designed as a prospective, open-label trial involving healthy male volunteers. A total of 48 men, […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Quality of Life in Subcutaneous or Transvenous Implantable Cardioverter-Defibrillator Patients: A Secondary Analysis of the PRAETORIAN Trial
Quality of Life in Patients with Subcutaneous or Transvenous Implantable Cardioverter-Defibrillators Study Overview The subcutaneous implantable cardioverter-defibrillator (S-ICD) was designed to reduce complications linked to the transvenous version (TV-ICD). This study looks at how these two devices affect patients’ quality of life. Methodology In the PRAETORIAN trial, patients needing an implantable cardioverter-defibrillator were randomly assigned […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEfficacy of Terpinen-4-ol Combined With Eyelid Deep Cleaning for the Treatment of Demodex Blepharitis: A Randomized, Open-Label Trial
Efficacy of Terpinen-4-ol Combined With Eyelid Deep Cleaning for Demodex Blepharitis Purpose This study aimed to test how well a treatment using terpinen-4-ol (T4O) and eyelid deep cleaning works for Demodex blepharitis. Methods We conducted a trial with 40 patients diagnosed with Demodex blepharitis at the Cornea Specialty Clinic of Hankou Aier Eye Hospital. Participants […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseClinical evaluation of the efficacy of focused extracorporeal shock-wave therapy in patients with cervical spondylosis: A randomized control trial
Clinical Trial on Focused Extracorporeal Shock-Wave Therapy for Cervical Spondylosis Study Overview Extracorporeal Shock Wave Therapy (ESWT) is a modern physiotherapy treatment that helps with muscle and bone issues. This study specifically looked at how effective focused ESWT (fESWT) is for relieving pain and improving function in patients with cervical spondylosis, a neck condition. Study […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseCare to Explain? AI Explanation Types Differentially Impact Chest Radiograph Diagnostic Performance and Physician Trust in AI
Understanding the Impact of AI Explanations on Radiology Study Overview This study explores how different types of AI explanations affect the ability of doctors to diagnose chest X-rays and their trust in AI. It aimed to find out if AI explanations help or hinder doctors in making decisions. Research Details The study was conducted from […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Survival outcomes of population-wide colonoscopy screening: reanalysis of the NordICC data
Survival Outcomes of Colonoscopy Screening: Key Findings Background Colonoscopy is a common method used to screen for colorectal cancer, but strong evidence supporting its effectiveness is lacking. The NordICC trial, the first randomized study on colonoscopy screening, showed no clear benefits for the general population. However, some benefits were suggested for specific groups. This study […] ➡️➡️➡️