Clinical trials

Efficacy of Seventh Generation Bonding Agents as Desensitizers in Patients with Dentin Hypersensitivity: A Randomized Clinical Trial Background Dentin hypersensitivity (DH) causes intense, transient pain in a significant portion of the global population, especially those aged 20-40. This study evaluates the effectiveness of seventh-generation dentin bonding agents in reducing DH compared to a control group […] ➡️➡️➡️

Improving Musculoskeletal Procedural Training Study Overview Physicians often lack proper instruction in musculoskeletal (MSK) procedures, leading to inaccurate diagnostic and therapeutic injections. This study aimed to compare the accuracy and technique of trainees practicing subacromial injections (SAI) on cadavers versus those receiving visual-aided instruction. Study Methods In Spring 2022, 24 Internal Medicine and Family Medicine […] ➡️➡️➡️

Weight Loss Treatment for COVID-19 in Patients with NCDs: A Pilot Prospective Clinical Trial Practical Solutions and Value Highlights The study evaluated the effects of a restricted diet on inflammation, metabolic profile, and body composition in COVID-19 patients with noncommunicable chronic diseases (NCDs). This included type 2 diabetes (T2D), hypertension, or nonalcoholic steatohepatitis (NASH). Interventions […] ➡️➡️➡️

Study: Pigtail with Self-Retaining Bicanalicular Intubation and Mitomycin C for Lower Punctal Stenosis Background The study used a pigtail to create an opening at the lower punctal site in grade 0 stenosis and inserted a self-retaining tube along with Mitomycin C (MMC). Methods Patients with acquired lower punctal stenosis (grade 0) were randomly divided into […] ➡️➡️➡️

Optimizing Outcomes in Psychotherapy for Anxiety Disorders Using Smartphone-Based and Passive Sensing Features: Protocol for a Randomized Controlled Trial Background Psychotherapies like cognitive behavioral therapy (CBT) are effective for anxiety disorders, but not everyone benefits from them. This study aims to use digital assessments and passive sensing features to better identify patients who would benefit […] ➡️➡️➡️

Empowering Low-Income Patients with Home Blood Pressure Monitors to Improve Hypertension Control ABSTRACT Managing hypertension (HTN) is vital in primary care, especially for uninsured and low-income patients. This study assessed the impact of providing free home blood pressure (BP) monitors on patients’ HTN control and therapy adherence at an underserved community clinic. The results showed […] ➡️➡️➡️

Acupuncture for Chronic Radiation-Induced Xerostomia in Head and Neck Cancer: A Multicenter Randomized Clinical Trial Key Points: Comparison of true acupuncture (TA), sham acupuncture (SA), and standard oral hygiene (SOH) for treating radiation-induced xerostomia. TA shown to be more effective in treating chronic radiation-induced xerostomia than SA or SOH. Results: 258 patients participated from 33 […] ➡️➡️➡️

Effects of Ninjin’yoeito on Patients with COPD and Comorbid Frailty and Sarcopenia Study Details Published in the International Journal of Chronic Obstructive Pulmonary Disease in May 2024, this study aimed to investigate the effects of Ninjin’yoeito, a herbal medicine, on comorbid frailty and sarcopenia in patients with chronic obstructive pulmonary disease (COPD). Findings Patients with […] ➡️➡️➡️

Plexin B2 Tissue Expression and Gene Polymorphisms in Psoriasis Study Overview Psoriasis is a chronic skin disease with unclear causes. Plexin B2, found in the immune system, may be involved in psoriasis development. This study aimed to assess plexin-B2 tissue levels and related gene polymorphisms in psoriatic patients before and after NB-UVB, acitretin therapy alone […] ➡️➡️➡️

Study Highlight Dapagliflozin added to metformin helps reduce perirenal fat layer in type 2 diabetic patients with obesity Practical Solutions and Value The study shows that combining metformin with dapagliflozin can lead to significant reductions in abdominal fat, particularly in the perirenal fat layer. This combination treatment was more effective in reducing fat compared to […] ➡️➡️➡️

Two-Month Consumption of Orange Juice Enriched with Vitamin D3 and Probiotics: Clinical Trial Results Key Findings: Consuming orange juice enriched with vitamin D3 and probiotics for 8 weeks led to significant improvements in metabolic and inflammatory markers, blood pressure, and body weight in high-cardiometabolic-risk patients following a Westernized diet. Practical Solutions and Value: The enriched […] ➡️➡️➡️

Comparison of Catheter Ablation and Pacemaker Implantation for Tachycardia-Bradycardia Syndrome Key Findings: A clinical trial compared the outcomes of catheter ablation (CA) and permanent pacemaker (PM) implantation as initial treatments for patients with tachycardia-bradycardia syndrome (TBS) and paroxysmal atrial fibrillation (AF). The study found that the rates of unexpected emergency room visits or hospitalizations due […] ➡️➡️➡️

Comparison of Spirofy™ and Vitalograph Alpha Touch™ Spirometers Study Overview Spirofy is India’s first portable, pneumotach flow-sensor-based digital spirometer designed for diagnosing asthma and COPD. This study compared Spirofy’s performance with the Vitalograph Alpha Touch spirometer in measuring lung capacities of healthy individuals, asthmatics, and COPD patients. The study also assessed the consistency between two […] ➡️➡️➡️

Non-vascular ATP-sensitive potassium channel activation and migraine attacks Objective To study the impact of NN414, a specific KATP channel opener, on inducing migraine attacks in individuals with migraine without aura. Methods Thirteen participants received NN414 and placebo on separate days. The study measured the difference in migraine attack incidence and other related factors. Results Out […] ➡️➡️➡️

Summary of Clinical Study on Qingfei Paidu Granules and Nonpharmacological Interventions for Asymptomatic COVID-19 Patients Background The study evaluated the effectiveness of Qingfei Paidu Granules (QFPG) and nonpharmacological interventions in managing asymptomatic novel coronavirus infection, acknowledging the significant role of Traditional Chinese Medicine (TCM) in pandemic intervention. Methods Asymptomatic individuals were randomly assigned to three […] ➡️➡️➡️

Comparison of Atorvastatin and Rosuvastatin Effects on Bone Turnover in Postmenopausal Women Key Findings: • Statins, commonly used for dyslipidemia, may have additional benefits on bone health. • This study compared the impact of atorvastatin and rosuvastatin on bone turnover in postmenopausal women. • After 12 months, atorvastatin showed potential superiority in inhibiting adverse changes […] ➡️➡️➡️

Neuromuscular Electrical Stimulation for Physical Function Maintenance during Hematopoietic Stem Cell Transplantation: Study Protocol Overview Hematopoietic stem cell transplantation (HCT) is a common treatment for blood cancers but can lead to long-term functional impairment, fatigue, and decreased quality of life. Traditional exercise is not consistently recommended or maintained by patients. This study aims to assess […] ➡️➡️➡️

Study Title: A Digital Cognitive-Physical Intervention for Attention-Deficit/Hyperactivity Disorder: Randomized Controlled Trial Background ADHD is a common neurodevelopmental disorder in children. This study aimed to assess the effectiveness of BrainFit, a digital intervention combining cognitive and exercise training, in reducing ADHD symptoms and improving executive function in school-aged children. Methods The study included 90 children […] ➡️➡️➡️

Long-Term Effect of Home Blood Pressure Self-Monitoring Plus Medication Self-Titration for Patients With Hypertension: A Secondary Analysis of the ADAMPA Randomized Clinical Trial Summary: BP self-monitoring and self-titration of antihypertensive medication, in combination with primary-care nursing involvement, were found to effectively lower blood pressure in the longer term without increasing health care use or adverse […] ➡️➡️➡️

Comparison of Treatments for Lateral Epicondylitis Study Overview This study compared the effectiveness of local massage, corticosteroid injection, and extracorporeal shock wave therapy (ESWT) in treating lateral epicondylitis (LE). Key Findings ESWT showed superior results compared to the other treatments, with significant improvements in clinical evaluation scores at the six-month follow-up. Practical Solutions and Value […] ➡️➡️➡️