Clinical trials
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseCost-Effectiveness of Computer-Assisted Cognitive Behavioral Therapy for Depression Among Adults in Primary Care
Cost-Effectiveness of Computer-Assisted Cognitive Behavioral Therapy for Depression Background About 1 in 5 adults experience depression, but less than half get help. Those with lower income and education face bigger challenges in accessing treatment. Computer-assisted cognitive behavioral therapy (CCBT) is a helpful and convenient method for treating depression, but we need to understand its cost-effectiveness […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseClinical efficacy and mechanism of the combination of autologous platelet-rich gel and recombinant human acidic fibroblast growth factor in the management of refractory diabetic foot
Clinical Efficacy of Combined Treatments for Diabetic Foot Ulcers Objective This study investigates how autologous platelet-rich gel (APG) combined with continuous vacuum-sealed drainage (CVSD) and recombinant human acidic fibroblast growth factor (rh-aFGF) can help heal diabetic foot ulcers (DFU). The goal is to understand the healing process better and find new treatment options. Methods Ninety […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseConventional colonoscopy vs. cap-assisted colonoscopy: there are differences in colonoscopy performance?
Conventional Colonoscopy vs. Cap-Assisted Colonoscopy Introduction Colonoscopy is the main method for diagnosing colorectal cancer. However, the results for detecting polyps and adenomas have varied with different devices. Objectives This study aims to see if there are differences in the diagnostic performance of conventional colonoscopy (CC) versus cap-assisted colonoscopy (CAC) for adenoma detection. Materials and […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseVisual Performance of School-age Children Wearing Dual-Focus Soft Contact Lenses: A Randomized Controlled Trial
Visual Performance of School-age Children Wearing Dual-Focus Soft Contact Lenses Background This study explores how dual-focus soft contact lenses (DFSCL) affect the vision of school-age children. Study Details We conducted a clinical trial with 64 children aged 8 to 12 years who needed vision correction. These children were divided into two groups: one group wore […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Study protocol for a multicenter randomized controlled trial on simulation-based communication training for pediatric cardiology trainees (SIMUL-CHD)
Study Overview: SIMUL-CHD Trial Purpose Effective communication between doctors and patients is essential, especially when discussing serious conditions like congenital heart diseases. To address communication challenges faced by medical professionals, we are introducing a simulation-based training program for pediatric cardiology trainees. This study will work with associations that support families of children with congenital heart […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseImpact of platelet-rich fibrin derivatives on patient morbidity and quality of life in palatal donor sites following free gingival graft surgery: a randomized clinical trial
Impact of Platelet-Rich Fibrin on Patient Recovery After Gum Surgery Study Overview This study looked at how platelet-rich fibrin (PRF) can help patients heal better after free gingival graft (FGG) surgery. PRF is a material that helps with tissue healing and can improve patient comfort and quality of life. What We Did We involved 39 […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseRespiratory complications of propofol, sevoflurane, and dexmedetomidine anesthesia for fiberoptic bronchoscopy in children aged 1 month to 3 years: a randomized trial
Respiratory Complications in Children Under Anesthesia Study Overview This study looked at how different anesthesia methods affect respiratory issues in young children during fiberoptic bronchoscopy (FOB). Objective The goal was to compare the effects of propofol, sevoflurane, and dexmedetomidine on respiratory complications in children aged 1 month to 3 years. Methods A total of 120 […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseRandomized Trial of Very Early Medication Abortion
Randomized Trial of Very Early Medication Abortion Background Medication abortion using mifepristone and misoprostol is proven to be safe and effective. However, there is limited data on its effectiveness when the pregnancy is very early and not visible through ultrasound. Methods We conducted a multicenter trial involving women seeking medication abortion within 42 days of […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Durable improvements in atopic dermatitis in the head and neck and across other anatomic regions with rocatinlimab
Significant Improvements in Atopic Dermatitis with Rocatinlimab Study Overview In a recent clinical trial, adult patients with moderate-to-severe atopic dermatitis (AD) were treated with rocatinlimab. This treatment showed **significant clinical improvements** compared to a placebo, particularly in the overall Eczema Area and Severity Index (EASI) score. Focus on Head and Neck Region AD often affects […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseThe effectiveness of a problem-solving intervention with workplace involvement on self-reported sick leave, psychological symptoms and work ability: a cluster randomised clinical trial
The Effectiveness of a Problem-Solving Intervention in the Workplace Study Overview This study examines a problem-solving intervention with workplace involvement (PSI-WPI) aimed at reducing sick leave and improving work ability among employees. It focuses on individuals experiencing mild to moderate mental health issues after a sick leave episode. Key Findings Participants: 199 individuals were invited, […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseComparison of protective effects of teneligliptin and luseogliflozin on pancreatic β-cell function: randomized, parallel-group, multicenter, open-label study (SECRETE-I study)
Comparison of Teneligliptin and Luseogliflozin on Pancreatic β-cell Function Study Overview This study aims to compare the effects of two medications, SGLT2 inhibitors (luseogliflozin) and DPP-4 inhibitors (teneligliptin), on pancreatic β-cell function in patients with type 2 diabetes. Study Details We conducted a 26-week study with 103 patients who had type 2 diabetes. Participants were […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseGeneral health and social outcomes 50 years after exposure to antenatal betamethasone: follow-up of a randomised controlled trial
Long-Term Effects of Antenatal Betamethasone: Key Findings Study Overview This study looked at the health and social outcomes of individuals who were exposed to antenatal betamethasone 50 years ago. Antenatal corticosteroids are given to pregnant women at risk of preterm birth to help reduce complications for newborns. Methodology We followed 424 adults whose mothers participated […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffects of pain neuroscience education combined with neuromuscular exercises on pain, functional disability and psychological factors in chronic low back pain: A study protocol for a single-blind randomized controlled trial
Study on Pain Management for Chronic Low Back Pain Objective Chronic low back pain (CLBP) is a common health issue. This study aims to see if combining Pain Neuroscience Education (PNE) with neuromuscular exercises (NMS) can improve pain and overall well-being more than using NMS alone. Methods We will conduct a trial with 60 participants […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
National Liver Cancer Screening Trial (TRACER) study protocol
National Liver Cancer Screening Trial (TRACER) Study Overview Background HCC Screening Recommendations: Guidelines suggest screening for liver cancer (HCC) in high-risk patients using ultrasound every six months, sometimes combined with a blood test for alpha-fetoprotein (AFP). However, this method often lacks effectiveness due to low patient adherence and sensitivity. Potential Solution: Blood-based biomarker panels, like […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseMechanism of cognitive processing for acupuncture action on generalized anxiety with naturally occurring consecutive partial sleep deprivation in early adulthood: a randomized controlled study and evaluation of event-related potentials
Understanding the Impact of Acupuncture on Generalized Anxiety Disorder Introduction: Generalized Anxiety Disorder (GAD) is a common mental health issue that often starts in adolescence or early adulthood. It results in persistent anxiety and can be worsened by Partial Sleep Deprivation (PSD), which is a significant risk factor for developing GAD. This condition can affect […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Whole-volume histogram analysis of spectral-computed tomography iodine maps characterizes HER2 expression in gastric cancer
Whole-Volume Histogram Analysis of Spectral-Computed Tomography Iodine Maps in Gastric Cancer Background Surgery is the main treatment for gastric cancer (GC), but finding effective alternatives for patients who cannot have surgery is important. About 15%-20% of advanced GC cases show HER2 overexpression, which influences treatment choices. Spectral-computed tomography (sCT) helps measure material compositions, and its […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Biomarkers of glucose-insulin homeostasis and incident type 2 diabetes and cardiovascular disease: results from the Vitamin D and Omega-3 trial
Biomarkers of Glucose-Insulin Homeostasis and Their Impact on Type 2 Diabetes and Cardiovascular Disease Study Overview This study investigates how certain biomarkers related to glucose and insulin levels can predict the risk of developing type 2 diabetes (T2D) and cardiovascular disease (CVD). It also explores whether vitamin D and omega-3 fatty acids can influence these […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
The effects of a 6-week intervention with Limosilactobacillus reuteri ATCC PTA 6475 alone and in combination with L. reuteri DSM 17938 on gut barrier function, immune markers, and symptoms in patients with IBS-D-An exploratory RCT
Study Overview This study explored the effects of a 6-week treatment with two types of probiotics on patients with diarrhea-predominant irritable bowel syndrome (IBS-D). Background IBS-D patients often experience increased intestinal permeability. Probiotics may help improve IBS symptoms and support gut health. Aim The study aimed to see how Limosilactobacillus reuteri ATCC PTA 6475 (single […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
WITHDRAWN: New thyroid fine needle aspiration biopsy needle. Prospective, randomized, clinical study
WITHDRAWN: New Thyroid Biopsy Study Overview The article titled “New thyroid fine needle aspiration biopsy needle” was published on July 15, 2014, but has been withdrawn. This decision was made by the Editors in Chief, Prof Aled Rees and Prof Maralyn Druce, in agreement with John Wiley and Sons Ltd. The withdrawal occurred because the […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseCost-effectiveness of an online supervised group physical and mental health rehabilitation programme for adults with post-COVID-19 condition after hospitalisation for COVID-19: the REGAIN RCT
Cost-Effectiveness of a Rehabilitation Program for Post-COVID-19 Patients Background After the COVID-19 pandemic, many people suffer from ongoing physical and mental health issues. Currently, there is no specific treatment for the various symptoms of post-COVID-19 condition. Rehabilitation programs may help improve the quality of life for these patients. This study examines the cost-effectiveness of a […] ➡️➡️➡️