Inflammatory Markers and Noncoding-RNAs Responses to HIIT and Berberine Supplementation in Prediabetic Men
Study Overview
This study compared the effects of two different models of high-intensity interval training (HIIT) with or without berberine supplementation on inflammatory markers and insulin resistance in middle-aged men with prediabetes and overweight or obesity.
Key Findings
- All exercise interventions led to significant reductions in high-sensitivity C-reactive protein (hs-CRP), interleukin-1β (IL-1β), insulin, fasting blood glucose (FBG), and insulin resistance index (HOMA-IR) compared to the non-exercising control group.
- Berberine supplementation resulted in a significant reduction in FBG and HOMA-IR compared to baseline.
- Low-compression HIIT uniquely exhibited more anti-inflammatory effects, as indicated by reductions in NLRP3 and H19, compared to high-compression HIIT.
- The addition of berberine to the exercise programs did not show additional benefits.
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