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Combined oral supplementation with magnesium plus vitamin D alleviates mild to moderate depressive symptoms related to long-COVID: an open-label randomized, controlled clinical trial
Summary of Clinical Trial Findings Study Focus This study investigated how well oral supplements of magnesium and vitamin D can reduce mild to moderate depression symptoms in people suffering from long-COVID. Key Outcomes Participants: 60 individuals aged around 53 years with low magnesium and vitamin D levels, along with mild to moderate depression. Method: Participants…
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase -
Effect of stress management based self-care counseling on glycemic control in women with gestational diabetes mellitus: a randomized controlled trial study
Effect of Stress Management on Blood Sugar Control in Pregnant Women with Gestational Diabetes Study Overview This study explores how stress management counseling can help control blood sugar levels in women with gestational diabetes mellitus (GDM). Stress can worsen GDM, so the goal was to see if self-care counseling could improve health outcomes. Study Details…
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase -
Study protocol of the PRINCESS trial-PReoperative INtermittent fasting versus CarbohydratE loading to reduce inSulin resiStance versus standard of care in orthopaedic patients: a randomised controlled trial
Study Overview of the PRINCESS Trial The PRINCESS trial investigates how different preoperative nutritional strategies affect insulin resistance in orthopedic patients undergoing surgery. Background Surgery can cause metabolic stress, leading to insulin resistance (IR) and high blood sugar levels. This can result in complications after surgery. Traditional fasting before surgery may worsen these issues. However,…
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase -
Efficacy of a Mobile Health-Based Behavioral Treatment for Lifestyle Modification in Type 2 Diabetes Self-Management: Greenhabit Randomized Controlled Trial
Efficacy of a Mobile Health-Based Behavioral Treatment for Lifestyle Modification in Type 2 Diabetes Self-Management: Greenhabit Randomized Controlled Trial Background Using digital tools can help patients with type 2 diabetes (T2D) manage their health better. Objective This study looks at whether the Greenhabit mobile app improves T2D management compared to standard care. Methods A 12-week…
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase -
Integrating Videoconferencing Therapist Guidance Into Stepped Care Internet-Delivered Cognitive Behavioral Therapy for Child and Adolescent Anxiety: Noninferiority Randomized Controlled Trial
Integrating Videoconferencing Therapist Guidance Into Stepped Care Internet-Delivered Cognitive Behavioral Therapy for Child and Adolescent Anxiety Study Overview This study explores a new way to deliver cognitive behavioral therapy (CBT) for children and adolescents with anxiety. It compares two methods: ICBT-SC[VC]: Internet-delivered CBT with therapist guidance through videoconferencing only when needed. ICBT-TG[VC]: Full internet-delivered CBT…
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase -
HEalth-Related Quality of Life-Intervention in Survivors of Breast and Other Cancers Experiencing Cancer-Related Fatigue and Associated Cognitive Symptoms Using TraditionAL Chinese Medicine: The ‘HERBAL’ Trial
Health-Related Quality of Life Intervention for Cancer Survivors: The ‘HERBAL’ Trial Introduction This study explores the use of traditional Chinese medicine (TCM) to help cancer survivors deal with fatigue and cognitive symptoms. We specifically looked at a TCM blend called modified Xiang Bei Yang Rong Tang (XBYRT) and compared its effects on quality of life…
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase -
Assessing the effectiveness of the SOLIO Alfa Cure Plus device in treating low back pain: a randomized controlled study
Assessing the Effectiveness of the SOLIO Alfa Cure Plus Device for Low Back Pain Study Overview Nonspecific low back pain (LBP) is a major global health issue, affecting 84% of people at some point in their lives. Of these, 23% suffer from chronic pain, which disrupts daily activities. The SOLIO Alfa Cure Plus device, designed…
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase -
A multicenter, randomized, open label, two formulation, crossover bioequivalence trial of doxorubicin hydrochloride liposomal injection in Chinese patients with metastatic breast cancer
Multicenter Bioequivalence Trial of Doxorubicin in Chinese Metastatic Breast Cancer Patients Purpose The main goal of this trial was to study how a new liposomal injection of doxorubicin hydrochloride works in Chinese patients with metastatic breast cancer, comparing it to a standard formulation. Methods This study used a randomized, open-label design where patients received both…
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase -
Deep neuromuscular blockade during radiofrequency catheter ablation under general anesthesia reduces the prevalence of atrial fibrillation recurrence when compared to moderate neuromuscular blockade: A randomized controlled trial
Deep Neuromuscular Blockade in Atrial Fibrillation Treatment Study Overview This study investigates how deep neuromuscular blockade affects the recurrence of atrial fibrillation (AF) after catheter ablation. Proper anesthesia is crucial for patient stability during the procedure. Methodology Patients were divided into two groups: Moderate Neuromuscular Blockade (Group M) and Deep Neuromuscular Blockade (Group D). The…
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase -
Prospective Validation of an Automated Hybrid Multidimensional MRI Tool for Prostate Cancer Detection Using Targeted Biopsy: Comparison with PI-RADS-based Assessment
Validation of an Automated MRI Tool for Prostate Cancer Detection Study Overview This study aimed to test an automated hybrid multidimensional MRI (HM-MRI) tool for identifying prostate cancer before biopsies, comparing it with traditional evaluations by expert radiologists using the PI-RADS system. Key Findings The study involved 91 men, average age 65, who underwent MRI…
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase