Intranasal Insulin Diminishes Postoperative Delirium and Elevated Osteocalcin and Brain Derived Neurotrophic Factor in Older Patients Undergoing Joint Replacement: A Randomized, Double-Blind, Placebo-Controlled Trial

Intranasal Insulin Reduces Postoperative Delirium in Older Patients

Study Overview

This study explored how intranasal insulin affects older patients after joint replacement surgery. It aimed to see if this treatment could lower the chances and severity of postoperative delirium (POD) and improve insulin sensitivity markers.

Key Findings

  • Participants: 212 older patients (65 years and above) were involved.
  • Groups: Patients were split into two groups—one received 40 IU of intranasal insulin, while the other received a placebo for 8 days.
  • Results:
    • Intranasal insulin reduced the incidence of delirium significantly (8.33% vs 23.23%) within 5 days after surgery.
    • It also lowered the severity of delirium symptoms.
    • Insulin treatment increased levels of important biomarkers like total osteocalcin (tOC), uncarboxylated osteocalcin (ucOC), and brain-derived neurotrophic factor (BDNF).
    • Insulin administration improved insulin sensitivity over time.

Practical Solutions and Value

This study highlights the potential of intranasal insulin as a beneficial treatment for older patients undergoing surgery. By reducing delirium and improving insulin sensitivity, it can enhance recovery and overall patient well-being.

To support healthcare professionals, our AI-driven platform, DocSym, combines clinical guidelines and research into one easy-to-use resource. This helps clinicians provide better care and manage patient information efficiently.

In today’s fast-paced healthcare environment, our mobile apps simplify operations by aiding in scheduling, monitoring treatments, and facilitating telemedicine. This streamlines patient management and expands digital services.

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