Intranasal Insulin Reduces Postoperative Delirium in Older Patients
Study Overview
This study explored how intranasal insulin affects older patients after joint replacement surgery. It aimed to see if this treatment could lower the chances and severity of postoperative delirium (POD) and improve insulin sensitivity markers.
Key Findings
- Participants: 212 older patients (65 years and above) were involved.
- Groups: Patients were split into two groups—one received 40 IU of intranasal insulin, while the other received a placebo for 8 days.
- Results:
- Intranasal insulin reduced the incidence of delirium significantly (8.33% vs 23.23%) within 5 days after surgery.
- It also lowered the severity of delirium symptoms.
- Insulin treatment increased levels of important biomarkers like total osteocalcin (tOC), uncarboxylated osteocalcin (ucOC), and brain-derived neurotrophic factor (BDNF).
- Insulin administration improved insulin sensitivity over time.
Practical Solutions and Value
This study highlights the potential of intranasal insulin as a beneficial treatment for older patients undergoing surgery. By reducing delirium and improving insulin sensitivity, it can enhance recovery and overall patient well-being.
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