Clinical research

Integration of Case-Based Learning and Three-Dimensional Printing for Tetralogy of Fallot Instruction Key Findings: Combining case-based learning (CBL) with 3D-printed models results in improved performance in post-class examinations, particularly in pathological anatomy and TOF imaging data analysis. Students in the CBL-3DP group reported enhanced satisfaction with teaching mode, improved diagnostic skills, bolstered self-assurance in managing TOF cases, and cultivation of critical thinking and clinical reasoning abilities. Implications: The fusion of CBL with 3D printing models is feasible and effective in TOF instruction for clinical medical undergraduates, offering practical solutions for mastering instructional content, bolstering student interest, and increasing self-confidence in… ➡️➡️➡️

Detection of Scapholunate Interosseous Ligament Injury Key Findings Comparison of injury detection methods for scapholunate ligament injuries 4DCT imaging showed utility for diagnosing ligamentous wrist injury CT-derived biomarkers, arthrokinematics, were used to assess injury status Significantly greater interosseous proximities in injured versus uninjured wrists Improved early diagnosis and confirmation of scapholunate ligament injury Clinical Trial Impact Clinical trials play a crucial role in developing safe and effective treatments Integration of ICD-11 standards, clinical protocols, and research into a single, accessible knowledge base for clinicians Streamlining operations through mobile apps for scheduling, treatment monitoring, and telemedicine AI-driven workflows can enhance clinic… ➡️➡️➡️

Evaluation of Yukwool-tang for Major Depressive Disorder in Women Summary This study aimed to evaluate the effectiveness and safety of Yukwool-tang (YWT) for Major Depressive Disorder (MDD) in women. Method 72 MDD patients were randomly assigned to the YWT or placebo group and received treatment for 8 weeks, with various assessments conducted throughout the trial. Results YWT improved depression and accompanying symptoms in women with MDD, although not significantly compared to placebo. The treatment may be effective in reducing hopelessness. Conclusion Further research is needed to clarify the effects of YWT and overcome certain limitations. Practical Solutions and Value Clinical… ➡️➡️➡️

Effects of Speculum Lubrication on Cervical Smears for Cervical Cancer Screening: A Double Blind Randomized Clinical Trial Background Speculum lubrication may reduce pain during Pap-smear collection, potentially increasing uptake of cervical cancer screening. However, concerns exist about its impact on cytological results. Aim To compare the adequacy of cervical cytology smears and pain scores of women undergoing cervical cancer screening with or without speculum lubrication. Methods A randomized controlled study of 132 women undergoing cervical cancer screening at a Nigerian tertiary hospital. Participants were assigned to ‘Gel’ or ‘No Gel’ groups. Pap smears were collected with a lubricated or non-lubricated… ➡️➡️➡️

Examining the Effects of a Brief, Fully Self-Guided Mindfulness Ecological Momentary Intervention on Empathy and Theory-of-Mind for Generalized Anxiety Disorder: Randomized Controlled Trial ABSTRACT The study investigated the effectiveness of a 14-day, self-guided mindfulness intervention on empathy and theory-of-mind in adults with generalized anxiety disorder (GAD). Key Findings The mindfulness intervention showed improvements in specific empathy and theory-of-mind domains for individuals with GAD. The effects were particularly notable in fantasy, personal distress, and perspective-taking empathy domains. Theory-of-mind also improved with the mindfulness intervention. Observed effect sizes were small to moderate. Practical Implications Higher-intensity, self-guided or coach-facilitated mindfulness interventions may be… ➡️➡️➡️

Exploring Therapeutic Mechanisms of Chuan Huang Fang-II in the Treatment of Acute Kidney Injury on Chronic Kidney Disease Patients Study Information Journal: Ren Fail. 2024 Dec;46(1):2356021 DOI: 10.1080/0886022X.2024.2356021 Date: Epub 2024 May 24 Objective This study evaluates the effectiveness and safety of CHF-II combined with RG for treating AKI on CKD (A on C) and investigates potential therapeutic mechanisms through lipidomics analysis. Methods 98 patients were randomly assigned to the RG or RG + CHF groups. Both groups received RG therapy, with the RG + CHF group also receiving CHF-II treatment for two weeks. Evaluation endpoints included changes in renal… ➡️➡️➡️

Evaluating Palliative Care Case Conferences in Primary Care for Patients with Advanced Non-Malignant Chronic Conditions: KOPAL Trial Background Patients with congestive heart failure (CHF), chronic obstructive pulmonary disease (COPD), and dementia often do not receive specialist palliative home care (SPHC) despite the complexity of their conditions. Collaboration between general practitioners (GPs) and SPHC teams is crucial to effectively meet their needs. Objective To facilitate joint palliative care planning and the timely transfer of patients with advanced chronic non-malignant conditions to SPHC. Methods A cluster-randomised controlled trial involving 49 GP practices in northern Germany. The KOPAL intervention included a SPHC nurse-patient… ➡️➡️➡️

A Comparison of Pain Relief Methods after Laparoscopy Objective To compare the effectiveness of using bupivacaine alone versus bupivacaine combined with dexmedetomidine for pain relief after laparoscopy procedures. Method A study conducted at a cancer hospital in Lahore, Pakistan, involving adult patients undergoing laparoscopy. Patients were divided into two groups, with Group A receiving bupivacaine and Group B receiving bupivacaine plus dexmedetomidine. Pain levels and other relevant data were recorded and analyzed. Results No significant difference was found in pain relief between the two groups, and no side effects were reported during the study. Conclusion The combination of dexmedetomidine and… ➡️➡️➡️

Comparison of Propolis and Gluma Desensitizer for Dentin Hypersensitivity Key Findings: Propolis and Gluma desensitizers were compared in a randomized controlled trial for managing dentin hypersensitivity. Immediate reduction in dentin hypersensitivity was observed with both agents. After one month, Gluma was found to be more effective than propolis. Practical Solutions and Value: Clinical trials are crucial for developing safe and effective treatments. Our AI-driven platform, DocSym, consolidates ICD-11 standards, clinical protocols, and research for easy access by clinicians. Streamlining operations is essential in today’s healthcare environment. Our mobile apps support scheduling, treatment monitoring, and telemedicine to improve patient care and… ➡️➡️➡️

Early Diagnosis of Melanoma: Impact of Smartphone Photo Transmission on Dermatological Consultation Time Background: Difficulty in obtaining timely dermatological consultation hinders early melanoma diagnosis. Optimizing patient care pathways is crucial to improve patient outcomes. Methods: A randomized controlled study involved 51 French GPs and 250 patients referred for suspected melanoma lesions. GPs were randomized to either the smartphone arm or the usual care arm. In the smartphone arm, GPs sent photographs of suspicious lesions to dermatologists for assessment, while in the usual care arm, GPs followed their typical referral practice. Results: The study included 125 patients in each arm. The… ➡️➡️➡️

Preventive Efficacy of Silver Diamine Fluoride and CPP-ACP Fluoride Varnish on Molars Affected by Molar Incisor Hypomineralization in Children Overview This study compared the effectiveness of silver diamine fluoride (SDF) and Casein Phosphopeptide-Amorphous Calcium Phosphate fluoride Varnish (CPP-ACPFV) in preventing caries, enamel breakdown, and sensitivity in children with molar incisor hypomineralization (MIH). Key Findings The study found that SDF demonstrated a lower incidence of caries and a higher rate of caries arrest compared to CPP-ACPFV. Both treatments showed promise in preventing enamel breakdown and improving sensitivity. Practical Solutions These results highlight the potential of SDF and CPP-ACPFV as effective treatments… ➡️➡️➡️

Feasibility Study: Medical Imaging as Therapeutic Patient Education Tool in Radiotherapy Key Findings Cancer is a major public health challenge, and radiotherapy is a crucial treatment option. Medical imaging, previously used mainly by professionals, is now being explored for patient education. An experimental study at the University Hospital of Liège showed promising results. Patients who received 3D visualization of their own medical images reported improved knowledge, decreased anxiety, and reduced depression. The low refusal rate (8.2%) among the 15 patients recruited highlights the potential for wider use of medical imaging in patient education. Practical Solutions Our AI-driven platform, DocSym, consolidates… ➡️➡️➡️

Study on Refeeding Syndrome in Older Hospitalized Patients Background and Objectives Refeeding syndrome (RFS) lacks a global definition and diagnostic criteria. This study investigated the incidence of RFS and mortality rates in older hospitalized patients using three different diagnostic criteria: serum phosphate (traditional criterion), the Friedli consensus recommendations, and the ASPEN. Methods A total of 85 malnourished hospitalized patients at risk of RFS were included in this longitudinal study. Patients were provided with enteral tube feeding, and electrolytes were measured daily. Incidences of RFS were recorded, and mortality rates were compared between patients with and without RFS. Regression analysis and… ➡️➡️➡️

Exploring concurrent validity of the CLN2 Clinical Rating Scale: Comparison to PedsQL using cerliponase alfa clinical trial data ABSTRACT The CLN2 Clinical Rating Scale assesses disease progression in CLN2 disease, a rare neurodegenerative disorder. To validate the scale, it was compared to the Pediatric Quality of Life Inventory (PedsQL) using clinical trial data on cerliponase alfa treatment for CLN2 disease. Linear regression and mixed effects models were used to study the relationship between the Clinical Rating Scale and PedsQL in a clinical trial involving 23 children with CLN2 disease treated with cerliponase alfa for at least 96 weeks. Correlations between… ➡️➡️➡️