Clinical Trials

Background There are few effective treatments for older patients with acute myeloid leukemia (AML). A study was done to test a new treatment combining pegylated liposomal doxorubicin (PLD), low-dose cytarabine (LDAC), and granulocyte colony-stimulating factor (G-CSF) for elderly patients newly diagnosed with AML. Study Details Twenty-two patients were included in the study. The average age […] ➡️➡️➡️

Background Caregivers of people with Alzheimer’s disease often overlook their own health, especially their stress levels. This is particularly true for African American women, who are at higher risk for high blood pressure. Ongoing stress from caregiving and high blood pressure increases the risk of heart disease. It’s important to address stress to improve caregivers’ […] ➡️➡️➡️

Background Research shows that primary care can help manage chronic diseases, even in places with limited resources. However, we need to understand the long-term effects of these interventions. This study looked at a program called SINEMA, which used technology to help stroke patients, and how it affected their survival rates six years after the trial […] ➡️➡️➡️

Study Overview This study evaluates the effectiveness of different energy sources used in a procedure called en-bloc transurethral resection of bladder tumors (ERBT). The goal is to understand how these methods impact patient outcomes during and after surgery. Methods The research analyzed data from a clinical trial involving patients who underwent ERBT or conventional transurethral […] ➡️➡️➡️

Purpose of the Study This study aimed to find a better way to analyze microperimetry data, which helps evaluate the effectiveness of gene therapy for inherited retinal diseases (IRDs). Methods We looked at data from a phase II trial of AGTC-501 in patients with X-linked retinitis pigmentosa (XLRP). We used a special device called the […] ➡️➡️➡️

Study Overview This study aimed to compare the effectiveness of two types of 0.05% cyclosporine eye drops—an aqueous solution and an oil emulsion—in treating patients with moderate-to-severe dry eye disease. Study Design The research was a prospective randomized clinical trial involving 88 patients who were divided into two groups. One group received the aqueous solution, […] ➡️➡️➡️

Introduction Testing for HIV among male partners of pregnant women is crucial for better health outcomes for everyone involved. However, many men in Africa still do not get tested. This study looked at how male peer outreach can help increase HIV testing rates in Uganda. Study Overview We conducted a trial in Kampala, Uganda, with […] ➡️➡️➡️

Study Overview This study looked at the effects of Salvia officinalis (also known as sage) on women with Polycystic Ovary Syndrome (PCOS). It aimed to see how this herb could help with metabolism and reduce oxidative stress in patients. Study Details The research was conducted in gynecology clinics in Iran. A total of 70 married […] ➡️➡️➡️

Background Antibiotics before cesarean delivery are generally recommended for all patients, but there are concerns about their effects on infants. This study tested the processes of a clinical trial involving low-risk women receiving either cefazolin (an antibiotic) or a placebo before elective cesarean delivery. Methods The trial was registered and included women aged 18 to […] ➡️➡️➡️

Background Head lice are common worldwide, especially in rural areas with lower incomes. They cause severe itching and can lead to infections that may have serious health effects. Ivermectin is effective against head lice and is also being tested for malaria prevention. This study looked at the causes of head lice and evaluated the effectiveness […] ➡️➡️➡️

Background Standard treatment for early triple-negative breast cancer (eTNBC) often includes anthracycline-containing chemotherapy, which can have serious side effects. This study looked at tumor biopsies to find gene networks that could help predict treatment success and survival after a different type of chemotherapy that doesn’t use anthracyclines. Study Methods In the WSG-ADAPT-TN trial, patients with […] ➡️➡️➡️

Background Breast cancer (BC) is the most common cancer among women worldwide. Early detection is crucial, and Breast Self-Examination (BSE) plays a key role in this process. This study aimed to evaluate how effective face-to-face and virtual education on BSE is, using the theory of planned behavior (TPB). Study Overview This randomized controlled trial involved […] ➡️➡️➡️

Overview of the Study The study focused on a new laser treatment for acne called the 589/1319 nm solid-state dual-wavelength (SSDW) laser. This laser is designed to reduce inflammation and oil production in acne without needing extra dyes. Study Details Eighteen patients with acne on both sides of their faces participated in the study. They […] ➡️➡️➡️

Overview of the Study This study focused on breast cancer survivors who often face long-lasting symptoms such as anxiety, stress, insomnia, menopausal symptoms, and cognitive issues. The goal was to find effective non-drug solutions to help these individuals. Study Method We conducted a three-part trial with 60 women in the UK who had a history […] ➡️➡️➡️

Overview of JS005 Clinical Trials JS005 is a new medication designed to treat moderate to severe plaque psoriasis. It works by targeting a specific protein in the body called IL-17A. Two studies were conducted to test its safety and effectiveness. Study Details Phase Ia Study: This initial study involved 40 healthy adults. It was designed […] ➡️➡️➡️

Background Intractable vascular anomalies (VAs) can cause serious symptoms and have a poor outlook. New treatment options are necessary. This study tested sirolimus, a medication, to see if it could help treat VAs. Study Details The study was conducted at four hospitals in Japan. Patients with VAs took sirolimus daily. The goal was to maintain […] ➡️➡️➡️

Background Mothers of low birth weight or preterm infants often experience more postpartum depression compared to those with full-term infants. Providing mental support in neonatal intensive care units (NICUs) is essential. Objective This study aimed to see if a psychological intervention using the Neonatal Behavioral Assessment Scale (NBAS) could help reduce depressive symptoms in mothers […] ➡️➡️➡️

Improving Colposcopy for Postmenopausal Women Postmenopausal women often face challenges during colposcopy, including: Easy bleeding due to thinning vaginal tissue Poor visibility during the procedure Lower sensitivity of colposcopy Study Overview To address these issues, we conducted a study to evaluate the effectiveness of a compound sea-buckthorn oil suppository as a pretreatment for colposcopy. The […] ➡️➡️➡️

Introduction Cervical cancer is a major health issue in Singapore, with only 43% of women getting screened, far below the 70% target. In 2019, HPV DNA testing was added to the screening program, but many women avoid it due to feelings of embarrassment, privacy concerns, and discomfort with clinician sampling. Self-sampling for HPV DNA testing […] ➡️➡️➡️

Predicting Cognitive Decline in Alzheimer’s Disease Trials Background and Purpose In Alzheimer’s disease (AD) treatment trials, about 40% of participants do not show any cognitive decline after 80 weeks. By identifying and excluding these individuals, we can enhance the effectiveness of treatment impact detection. Our goal was to create machine learning models that can identify […] ➡️➡️➡️