Clinical Trials

Purpose Pathologists diagnose prostate cancer using special stained slides from needle biopsies. Some labs use expensive tests for every case, which can cost more than what they get paid. This study looked at whether using an AI tool can help reduce these costs while still keeping diagnosis safe. Methods Patients suspected of having prostate cancer […] ➡️➡️➡️

Understanding the Impact of Frailty on Cognitive Health Background: Frailty often occurs alongside dementia, which can affect cognitive abilities. Research has shown that a comprehensive lifestyle change can improve cognitive function. Our study aimed to see if frailty influences the effectiveness of these lifestyle changes. Study Overview The Finnish Geriatric Intervention Study (FINGER) included 1,259 […] ➡️➡️➡️

Purpose Women taking aromatase inhibitors (AIs) for breast cancer often suffer from joint pain, stiffness, and muscle weakness. This study looked at whether aerobic exercise can help reduce these symptoms. Methods In this study, 136 postmenopausal women with breast cancer were divided into two groups: one group did moderate-intensity aerobic exercise for 6 months, while […] ➡️➡️➡️

Purpose Understanding how nutrition affects health in people with metabolic issues is difficult. We need sensitive tools to measure this. A new method called phenotypic flexibility helps us see how the body responds to challenges. A special biomarker has been useful in studying the health benefits of whole-grain wheat for overweight and obese individuals. We […] ➡️➡️➡️

“`html Objective This research looked at how different types of hemodialysis, when combined with low-calcium dialysate (LCD), affect mineral balance and blood vessel hardening in patients with chronic kidney disease (CKD) who are on maintenance hemodialysis (MHD). Methods Data was gathered from 192 MHD patients, who were divided into four groups. Each group received LCD […] ➡️➡️➡️

Introduction Sexual minority women face high risks of dangerous drinking and mental health issues like depression and anxiety. Research shows that stress from societal stigma affects their drinking habits and mental well-being. However, no effective treatments have been tested specifically for this group. This article introduces Project EQuIP, a study designed to test a special […] ➡️➡️➡️

Introduction Chemotherapy can cause serious side effects, especially damage to the digestive system, known as gastrointestinal mucositis (GI-M). This can lead to problems like diarrhea, weight loss, pain, fatigue, and sleep issues. Managing these symptoms often requires multiple medications, which can be risky. The CANCAN trial explores how medicinal cannabis might help reduce these side […] ➡️➡️➡️

Summary of Research on Exercise and Decision Making This study explored how short sessions of aerobic exercise impact risky decision making and reward processing in young adults. Key Findings Researchers looked at 60 participants, both male and female, who either exercised for 20 minutes on a treadmill or watched a video. They tested decision-making skills […] ➡️➡️➡️

“`html Background Quick diagnosis is essential for treating acute spinal cord injuries (SCI). We believe that a special blood test can help diagnose SCI, measure how serious the injury is, and predict long-term recovery. Methods We developed a blood test that looks for specific DNA markers in the blood of patients with acute SCI. We […] ➡️➡️➡️

Key Findings from the PhALLCON Study In March 2024, the FDA approved ponatinib for treating newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph + ALL) alongside chemotherapy. This decision was based on the Phase 3 PhALLCON study, which showed that ponatinib resulted in a better chance of achieving remission without detectable cancer cells compared to […] ➡️➡️➡️

Study Overview The research focuses on a treatment called Chlorophyllin (CHL) for patients suffering from brain radionecrosis due to diffuse glioma. This study shows that CHL may help reduce the negative effects of radiation therapy. Study Details This is a phase 2 clinical trial involving adults over 18 years old with diffuse glioma experiencing radionecrosis. […] ➡️➡️➡️

Background Detecting tuberculosis (TB) cases is crucial for controlling the disease, especially in countries like Ethiopia where TB is common. This study looked at combining traditional and modern TB care to improve detection rates. Study Overview A trial took place from February 2023 to January 2024 in six districts of South Gondar Zone, Northwest Ethiopia. […] ➡️➡️➡️

Background High blood pressure, or hypertension, is a major health risk for heart diseases. Most people with hypertension live in low- and middle-income countries. This study focuses on a traditional Ayurvedic treatment called Sarpagandha Mishran to see how well it works for managing Stage-I hypertension. Study Method This clinical trial is designed to be very […] ➡️➡️➡️

“`html Background Patients with chronic low back pain (CLBP) often struggle with poor posture due to weak core muscles. Dynamic neuromuscular stabilization (DNS) uses techniques based on how infants move to help improve muscle function. While DNS has helped improve posture in other conditions, it’s unclear if it works better for CLBP patients compared to […] ➡️➡️➡️

Overview of the Study This study focuses on patients with severe brain injuries who may experience disorders of consciousness (DoC) like Unresponsive Wakefulness Syndrome (UWS) and Minimally Conscious State (MCS). The aim is to improve diagnosis and treatment using a method called transcutaneous auricular vagus nerve stimulation (taVNS). Key Findings taVNS can help in identifying […] ➡️➡️➡️

Objective This clinical study looked at how well an experimental pregabalin (PG) gel can reduce dental sensitivity (DS) and color change after teeth whitening. Study Details Seventy-five volunteers participated and were divided into three groups: GPG: 10% pregabalin gel GKF: 5% potassium nitrate and 2% sodium fluoride GP: Placebo gel Before the whitening treatment, the […] ➡️➡️➡️

Study Overview This study examines the effects of using earmuffs on preterm neonates in a Neonatal Intensive Care Unit (NICU). Preterm babies are more sensitive to stress and noise, which can negatively affect their health. Key Findings Noise in NICUs: High noise levels can cause stress and instability in preterm neonates. Recommended Noise Level: The […] ➡️➡️➡️

“`html Study Overview This study focuses on Chronic Spontaneous Urticaria (CSU), a condition that greatly impacts patients’ quality of life. It compares the effectiveness of a treatment combining histaglobulin and antihistamine (bilastine) against using antihistamine alone. Trial Details The trial was conducted at a dermatology outpatient department in a tertiary care hospital from September 2023 […] ➡️➡️➡️

Understanding Postpartum Hemorrhage (PPH) Postpartum hemorrhage is the main reason for maternal deaths after childbirth. It’s important to identify excessive bleeding quickly, but there’s currently no standard method to measure it effectively. A Study on Measuring Blood Loss We conducted a study to compare two different methods of measuring blood loss in women who had […] ➡️➡️➡️

Healthcare Results and Solutions Objectives Children with hemiplegia have difficulty moving, especially on one side of their body. This can lead to uneven walking, problems with stability, and weak trunk muscles. This study looked at how a special training program could help improve walking, balance, and trunk strength in these children. Methods Forty children aged […] ➡️➡️➡️