Pilot Trial: Exercise Effects on Chemotherapy-Induced Nerve Damage Overview A pilot study investigated the impact of exercise on chemotherapy-induced peripheral neurotoxicity (CIPN) and the interoceptive brain system. Key Findings The study showed that exercise during chemotherapy can help reduce CIPN symptoms and signs, potentially through changes in brain circuitry. Practical Solutions Implementing exercise interventions, such…
Combined Interventions for HIV and Schistosomiasis in Malawi: Practical Solutions and Value Highlights: Undiagnosed HIV and schistosomiasis are common among Malawian fishermen near the African Great Lakes. Three-arm trial in 45 fishing communities assessed lakeside interventions for HIV and male genital schistosomiasis. Main outcomes were prevalence of schistosomiasis, uptake of antiretroviral therapy (ART), and voluntary…
Wearable Device-Based Intervention for Promoting Patient Physical Activity After Lung Cancer Surgery: A Nonrandomized Clinical Trial Summary Wearable devices can help lung cancer patients recover faster after surgery. This study looked at how using a wearable device affected physical activity, lung function, and quality of life after surgery. Key Findings Patients using the wearable device…
Perturbational Complexity Index in Assessing rTMS Treatment for Disorders of Consciousness Study Overview A clinical trial investigated the use of repetitive Transcranial Magnetic Stimulation (rTMS) in patients with Disorders of Consciousness (DoC). Patients in minimally conscious states participated in a randomized controlled trial to evaluate the effectiveness of rTMS in improving consciousness. Key Findings The…
Improving Gait Automaticity in Parkinson’s Disease Rehabilitation Summary: The study focused on enhancing gait automaticity in early-stage Parkinson’s disease through a new gait normalcy index based on dual task cost (NIDTC). Practical Solutions and Value: The turning-based NIDTC was found to be highly responsive in assessing gait automaticity improvement, making it a valuable tool for…
Phase IB Study on Induction Therapies for Primary Central Nervous System Lymphoma Overview A study was conducted to improve treatment for primary central nervous system lymphoma (PCNSL) patients. The trial tested combining R-MPV with escalating doses of lenalidomide or ibrutinib for newly diagnosed PCNSL cases. Key Findings Twenty-six patients were involved, with promising results. The…
An Optimized Strategy to Prevent HIV Transmission through Breastfeeding Study Overview A clinical trial called PREVENIR-PEV was conducted in Burkina Faso to prevent HIV transmission from mothers to infants through breastfeeding. The trial focused on identifying undiagnosed infants living with HIV during the 2nd immunization visit. Key Findings During the trial, 118 mothers living with…
Efficacy and Safety of Choline Alphoscerate for Amnestic Mild Cognitive Impairment Study Overview This study investigated the effectiveness and safety of choline alphoscerate (αGPC) in individuals with mild cognitive impairment. Participants were randomly assigned to receive either αGPC or a placebo for 12 weeks. Key Findings After 12 weeks, those who received αGPC showed a…
Palbociclib in Solid Tumor Patients With Genomic Alterations in the cyclinD-cdk4/6-INK4a-Rb Pathway: Results From National Cancer Institute-Children’s Oncology Group Pediatric Molecular Analysis for Therapy Choice Trial Arm I (APEC1621I) Key Findings: The study focused on pediatric patients with relapsed solid tumors treated with palbociclib, a cdk4/6 inhibitor. Practical Solutions: Using palbociclib at 75 mg/m2 orally…
Phase II Study of Samotolisib in Children and Young Adults With Tumors Harboring PI3K/mTOR Pathway Alterations Practical Solutions and Value Highlights: Clinical trials play a vital role in developing safe and effective treatments, which can be extended to everyday medical practice. DocSym, an AI-driven platform, consolidates ICD-11 standards, clinical protocols, and research into an easily…
Practical Solutions and Value Highlights 1. Utilizing Clinical Trials for Effective Treatments Clinical trials play a crucial role in developing safe and effective treatments. It is essential to translate their benefits into everyday medical practice. 2. DocSym: AI-Driven Platform for Clinical Knowledge DocSym, our AI-driven platform, consolidates ICD-11 standards, clinical protocols, and research into a…
Effects of Aquatic Physiotherapy on Knee Osteoarthritis Overview This study evaluates the impact of different aquatic physiotherapy techniques on patients with knee osteoarthritis. Key Points Focus on functional and biochemical improvements in knee osteoarthritis patients Three levels of aquatic physiotherapy intensity tested Assessment of MMP-3 and GPx levels in blood, pain, edema, and flexibility Practical…
Study Summary: Indocyanine Green Antimicrobial Photodynamic Therapy in Periodontal Maintenance Background Antimicrobial Photodynamic therapy using Indocyanine Green (ICG) is gaining attention for treating periodontitis. Limited data is available on its outcomes in maintenance patients. Methodology – 24 maintenance therapy patients with periodontitis underwent scaling and root planing. – Test group received ICG-based photodynamic therapy in…
The Effect of Wet Cupping Therapy on Adult-Onset Asthma: Results of Clinical Trial Overview A clinical trial studied the impact of wet cupping therapy on asthma symptoms in adults. Wet cupping is a traditional Persian method for treating various conditions. Study Details The trial involved 103 asthma patients at Loghman Hakim Hospital in Tehran, Iran.…
Effects of Adding Electro-Massage to Manual Therapy for Myofascial Temporomandibular Pain Summary: Study aimed to determine if adding electro-massage (ES) to manual therapy (MT) is more effective than MT alone for treating myofascial temporomandibular pain. Methodology: 46 participants with myofascial temporomandibular pain were split into two groups. Group 1 received MT on the neck and…
Local Ketorolac Infiltration for Postoperative Pain in Open Trigger Finger Surgery: A Randomized Controlled Trial Practical Solutions and Value Highlights: Multimodal analgesia is essential for managing postoperative pain effectively in minor hand surgeries, improving patient satisfaction. Local wound infiltration with Ketorolac is suggested as a strategy to manage pain in open trigger finger release surgery.…
Evaluation of Bowel Preparation for Colonoscopy Study Overview A study compared different bowel preparation methods for colonoscopy. It aimed to assess the effectiveness and patient tolerance of low-dose polyethylene glycol (PEG) combined with different doses of linaclotide. Key Findings The 2LPEG + 2L group showed the best bowel cleansing success (92.0%) compared to the other…
CCTA-Guided Invasive Coronary Angiography in Patients With CABG: A Multicenter, Randomized Study Background Coronary computed tomography angiography (CCTA) is highly accurate in visualizing grafts in patients with prior coronary artery bypass graft (CABG). Invasive coronary angiography (ICA) in these patients is associated with longer procedural time, increased contrast agent use, radiation exposure, and complications compared…
Feasibility, Acceptability, and Preliminary Evaluation of a User Co-Facilitated Psychoeducational Programme BMC Psychiatry. 2024 Sep 16;24(1):615. doi: 10.1186/s12888-024-06015-4. Background: Mental health settings are increasingly using co-facilitation of educational group interventions in collaboration with patient partners and service users. This study aimed to determine the feasibility, acceptability, and preliminary effects of a user co-facilitated psychoeducational group…
Effectiveness of Levidex in Improving Quality of Life for People with Multiple Sclerosis: Results of a Clinical Trial Background Multiple Sclerosis (MS) significantly impacts patients’ quality of life (QoL). Levidex, a digital health application based on cognitive behavioral therapy (CBT) principles, was tested in a randomized controlled trial to examine its effects on MS-related QoL…