Double-blind
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseIncreased risk of kidney failure in patients with genetic kidney disorders
Increased Risk of Kidney Failure in Patients with Genetic Kidney Disorders Practical Solutions and Value Highlights Recent study published in J Clin Invest revealed that patients with genetic kidney disorders are at higher risk of kidney failure. The study assessed three patient cohorts and found that monogenic kidney disorders and high-risk APOL1 genotypes were associated […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseSearching for the Scale-Able Weight Loss Intervention: Can One Size Fit All? Lessons to Be Learned from the EQUAL Trial
Lessons from the EQUAL Trial: Tailoring Weight Loss Interventions for Cancer Survivors Key Takeaways: Despite challenges, the EQUAL trial sheds light on the need for tailored, remotely delivered weight loss interventions for cancer survivors, particularly those with acute lymphoblastic leukemia (ALL). Key differences in study populations and intervention contexts contributed to the trial’s null results, […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffect of blue light emitting diode therapy on recurrent vulvovaginal candidiasis: A randomized assessor-blinded controlled trial
Effect of Blue Light Emitting Diode Therapy on Recurrent Vulvovaginal Candidiasis: A Randomized Assessor-Blinded Controlled Trial Objective Vulvovaginal Candidiasis (VVC) is a common genital infection in women and requires effective non-drug therapies. This study aimed to investigate the effect of blue light emitting diode (LED) therapy as an alternative treatment for recurrent VVC due to […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEfficacy and safety of methotrexate plus hydroxychloroquine combination therapy vs. methotrexate monotherapy in the treatment of rheumatoid arthritis: A randomized controlled clinical trial
Efficacy and Safety of Methotrexate Plus Hydroxychloroquine Combination Therapy vs. Methotrexate Monotherapy in the Treatment of Rheumatoid Arthritis: A Randomized Controlled Clinical Trial Key Findings: Combining methotrexate (MTX) with hydroxychloroquine (HCQ) showed a more significant reduction in pain, disease activity, and inflammatory factors compared to MTX monotherapy. The quality of life was also higher in […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseExploring the Effect of Exercise versus Metformin on Insulin Resistance amongst Nigerians with Pre-diabetes: A Randomised Controlled Trial
Exploring the Effect of Exercise versus Metformin on Insulin Resistance amongst Nigerians with Pre-diabetes: A Randomised Controlled Trial ABSTRACT Pre-diabetes is a significant risk factor for type 2 diabetes in Nigeria. This study aimed to compare the impact of moderate exercise and metformin interventions on insulin resistance among participants with pre-diabetes. Using a randomised placebo-controlled […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseReduced-dose chemotherapy and blinatumomab as induction treatment for newly diagnosed Ph-negative B-cell precursor acute lymphoblastic leukemia: a phase 2 trial
Reduced-dose chemotherapy and blinatumomab as induction treatment for newly diagnosed Ph-negative B-cell precursor acute lymphoblastic leukemia: a phase 2 trial Abstract Blinatumomab has shown promise in improving the initial treatment of acute B-cell precursor lymphoblastic leukemia (BCP-ALL). To reduce side effects and improve effectiveness, we conducted a phase 2 trial using reduced-dose chemotherapy (RDC) followed […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffect of endothelin-1 on the blood pressure response to acute hypoxia and hyperoxia in healthy young men
Effect of Endothelin-1 on Blood Pressure Response to Hypoxia and Hyperoxia in Young Men Physiological Reports, 2024 Sep;12(17):e70004 Endothelin-1 (ET-1) and its receptors have been linked to increased sensitivity to hypoxic stress and the development of hypertension. This study aimed to investigate the effect of ET receptor antagonism on blood pressure (BP) response to chemoreflex […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffect of intranasal insulin on perioperative cognitive function in older adults: a randomized, placebo-controlled, double-blind clinical trial
Effect of Intranasal Insulin on Perioperative Cognitive Function in Older Adults Key Findings: Administering intranasal insulin to older surgical patients showed significant improvement in postoperative cognitive function, reduced incidence of postoperative delirium, and inhibited certain inflammatory markers. Practical Solutions: Using intranasal insulin could be a potential therapy to enhance postoperative cognition in older surgical patients. […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Assessment of MMP levels in reversible and irreversible pulpitis and a randomized controlled trial comparing clinical success of two different calcium-silicate cements in pulpotomy treatment of primary molars with an 18-month follow-up
Assessment of MMP Levels and Clinical Success in Pulpitis and Pulpotomy Treatment Background Matrix metalloproteinases (MMPs) are crucial enzymes in dental pulp tissue function. However, their role in primary teeth remains limited. Further studies are needed to understand their contributions to pulpal defense in primary teeth. Additionally, the effectiveness of Biodentine in treating primary teeth […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
The combined application of pulsed electromagnetic fields and platelet-rich plasma in the treatment of early-stage knee osteoarthritis: A randomized clinical trial
The combined application of pulsed electromagnetic fields and platelet-rich plasma in the treatment of early-stage knee osteoarthritis: A randomized clinical trial Key Findings This study investigated the effectiveness of combining pulsed electromagnetic fields (PEMFs) and platelet-rich plasma (PRP) injections in treating early-stage knee osteoarthritis. The combined therapy was found to significantly reduce pain and improve […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffects of the Laying on of Hands on Stress, Depression, Fatigue, and Quality of Life in Oncology Patients: A Randomized, Double-Blind Clinical Trial
Effects of Laying on of Hands in Oncology Patients Study Details Published in Adv Mind Body Med. 2024 Summer;28(3):36-42. Conducted at the Center for Integrative and Complementary Practices of the Federal University of Triangulo Mineiro, MG, Brazil. Objective To investigate the effects of laying on of hands (LOH) with Spiritual connection (LHSP) and LOH without […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
VATICAN (Ventilator-Associated Tracheobronchitis Initiative to Conduct Antibiotic Evaluation): protocol for a multicenter randomized open-label trial of watchful waiting versus antimicrobial therapy for ventilator-associated tracheobronchitis
VATICAN Trial: Evaluating Antibiotic Treatment for Ventilator-Associated Tracheobronchitis Background: Ventilator-associated tracheobronchitis is a common condition in intensive care units, and the best treatment strategy is currently unknown. The VATICAN trial aims to compare watchful waiting with routine antibiotic treatment for this condition. Methods: The VATICAN trial is a randomized, controlled, open-label, multicenter noninferiority trial. Patients […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Efficacy and Safety of Reduced Dose Azacitidine in the Treatment of Elderly Patients with Myelodysplastic Syndromes
Efficacy and Safety of Reduced Dose Azacitidine in Elderly Patients with Myelodysplastic Syndromes Objective To analyze the efficacy and safety of low-dose azacitidine in treating elderly patients with myelodysplastic syndromes (MDS). Methods A total of 92 elderly MDS patients were divided into an observation group and a control group. The observation group received a low […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffect evaluation of outpatient long-term video EEGs for people with seizure disorders — study protocol of the ALVEEG project: a randomized controlled trial in Germany
Effect evaluation of outpatient long-term video EEGs for people with seizure disorders — study protocol of the ALVEEG project: a randomized controlled trial in Germany ABSTRACT Epilepsy and other seizure disorders have a significant impact in Germany. Timely diagnosis and accurate treatment are crucial, and the management of these disorders needs improvement. Outpatient long-term video […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseImpact of a package of point-of-care diagnostic tests, a clinical diagnostic algorithm and adherence training on antibiotic prescriptions for the management of non-severe acute febrile illness in primary health facilities during the COVID-19 pandemic in Burkina Faso
Impact of Intervention Package on Antibiotic Prescriptions for Acute Febrile Illness Study Overview An intervention package including point-of-care diagnostic tests, a clinical algorithm, and adherence training was implemented in primary health facilities in Burkina Faso during the COVID-19 pandemic. The study aimed to assess the impact of this package on antibiotic prescriptions and clinical recovery […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseMRI Tumor Regression Response to Neoadjuvant Chemotherapy Alone without Radiation for Rectal Adenocarcinoma
MRI Tumor Regression Response to Neoadjuvant Chemotherapy Alone without Radiation for Rectal Adenocarcinoma Summary This study investigated the accuracy of MRI in assessing pathologic complete response in patients with locally advanced rectal cancer (LARC) who underwent surgery after neoadjuvant chemotherapy (NCT) without radiation. The results show that MRI-based models were accurate for determining pathologic complete […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Management of the Axilla After Neoadjuvant Chemotherapy: Can Axillary Needle Biopsy Replace Sentinel Node Biopsy?
Management of the Axilla After Neoadjuvant Chemotherapy: Can Axillary Needle Biopsy Replace Sentinel Node Biopsy? Background The study aimed to determine if axillary needle biopsy could effectively evaluate the axilla after treatment in breast cancer patients who had received neoadjuvant chemotherapy (NAC) without the need for sentinel lymph node biopsy (SLNB). Patients and Methods The […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEvaluation of the impact of an online video game as an educational intervention on sexual health and the prevention, diagnosis, and treatment of sexually transmitted infection: A randomized controlled trial protocol
Evaluation of the Impact of an Online Video Game as an Educational Intervention on Sexual Health and the Prevention, Diagnosis, and Treatment of Sexually Transmitted Infection: A Randomized Controlled Trial Protocol Background The incidence of sexually transmitted infections (STIs) is increasing, especially among young people. There is a need for tools to improve knowledge about […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseThe impact of telemonitoring on correct drug use, complications and quality of life among patients with multiple myeloma (ITUMM): A study protocol for an open-label, parallel-group, randomized controlled trial
Impact of Telemonitoring on Multiple Myeloma Patients Practical Solutions and Value Multiple myeloma (MM) is a serious condition with significant impact on patients’ lives. To address the challenges of complex treatment regimens, the MM e-coach telemonitoring tool was developed and tested. This study aims to assess the impact of telemonitoring on medication adherence, complications, and […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Lay-Led Intervention for War and Refugee Trauma: A Randomized Clinical Trial
Lay-Led Intervention for War and Refugee Trauma: A Randomized Clinical Trial Importance The global refugee crisis disproportionately affects the Muslim world, leading to trauma-related mental health issues. Effective psychotherapy exists, but barriers to uptake by refugee groups and lack of culturally appropriate interventions remain. Objective To examine the efficacy of a brief, lay-led, mosque-based intervention, […] ➡️➡️➡️