Guselkumab Efficacy in Psoriasis: Key Findings from VOYAGE Studies Background The VOYAGE 1 and VOYAGE 2 studies showed that guselkumab is effective and safe for treating moderate-to-severe psoriasis for up to 5 years. This analysis looked at how effective guselkumab is based on the severity of the disease and previous treatments. Methods Patients were divided…
Alzheimer Disease Blood Biomarkers and Cognition Among Individuals With Diabetes and Overweight or Obesity Study Overview This study explores how blood-based biomarkers (BBMs) relate to cognitive health in older adults with type 2 diabetes (T2D) and obesity. These biomarkers can help diagnose Alzheimer’s disease (AD) and related dementias (ADRD). Study Goals The main aim was…
Shock Wave Therapy for Erectile Dysfunction: Key Findings and Practical Solutions Background Recent studies show that low-intensity shock wave therapy (LI-ESWT) is effective for treating erectile dysfunction, but challenges exist in reviewing these studies systematically. Aim This study aims to confirm the effectiveness of LI-ESWT and identify the best method for assessing erectile dysfunction in…
Laser Therapy vs. EGF Injection for Jaw Pain: A Clinical Trial Objective The goal of this study was to compare the effectiveness of Piano level laser therapy and epidermal growth factor (EGF) injection in relieving pain and improving function and quality of life for patients with myogenic temporomandibular disorder (TMD). Study Design We conducted a…
Supporting Older People with Cognitive Impairment During and After Hospital Stays Background The shift from hospital to primary care can negatively affect older adults with cognitive impairment. Objective This study aimed to evaluate if intersectoral care management could reduce hospital readmissions and improve daily functioning in these individuals. Study Design This was a longitudinal study…
Physical Activity in People with Borderline Personality Disorder Study Overview This study focuses on how physical activity (PA) can help individuals with borderline personality disorder (BPD). Current treatments like medication and therapy don’t always work effectively. This research aims to see if a PA program can improve symptoms and overall health in BPD patients. Study…
Intranasal Insulin Reduces Postoperative Delirium in Older Patients Study Overview This study explored how intranasal insulin affects older patients after joint replacement surgery. It aimed to see if this treatment could lower the chances and severity of postoperative delirium (POD) and improve insulin sensitivity markers. Key Findings Participants: 212 older patients (65 years and above)…
A Novel Description of Antithrombin Deficiency in Hospitalized COVID-19 Patients Objective Antithrombin (AT) helps reduce inflammation and blood clotting. We wanted to find out how common AT deficiency is in COVID-19 patients and if adding AT could help with blood clotting issues in these patients. Patients and Methods This study involved a randomized control trial.…
Supporting Primary Care Clinicians in Alcohol Use Disorder Treatment Study Overview Alcohol use disorder (AUD) is a major cause of preventable deaths in the U.S. Many people with unhealthy alcohol use do not receive proper treatment. This study aims to see if additional support for primary care providers (PCPs) can improve treatment engagement for patients…
Oral Lactoferrin for Treating Anemia in Children with Chronic Kidney Disease Study Overview Anemia in children often arises from chronic kidney disease (CKD), negatively impacting their health and well-being. Traditional treatments, like injectable iron, come with several side effects. Trial Details This clinical trial aimed to compare the effectiveness of oral lactoferrin versus intravenous (IV)…
Isatuximab, Bortezomib, Lenalidomide, and Limited Dexamethasone in Multiple Myeloma Treatment Overview of the Study This study explored the safety and effectiveness of isatuximab, bortezomib, lenalidomide, and limited dexamethasone for older patients with newly diagnosed multiple myeloma who are not eligible for stem cell transplants. Study Details Conducted between June 2021 and January 2023, the trial…
Aficamten vs Metoprolol for Obstructive Hypertrophic Cardiomyopathy: MAPLE-HCM Overview Study Background Beta-blockers and certain calcium-channel blockers are the usual treatments for patients with symptomatic obstructive hypertrophic cardiomyopathy (oHCM). However, these medications do not address the root cause of the disease. Cardiac myosin inhibitors, like aficamten, work differently by reducing excessive heart muscle contractions. They have…
An Incognito Standardized Patient Approach for Measuring and Reducing Intersectional Healthcare Stigma Study Overview This study focused on how stigma affects healthcare access for people living with HIV (PLWH) and men who have sex with men (MSM). We tested a training program for healthcare providers aimed at reducing this stigma. Study Setting The research took…
Metaverse Clinic for Pregnant Women With Subclinical Hypothyroidism Study Overview This study explores the use of a metaverse platform to help pregnant women with subclinical hypothyroidism (SCH), a common thyroid issue that can lead to problems during pregnancy. Study Purpose The goal is to check if the metaverse can safely and effectively manage SCH in…
Structure-Function Relationships in Geographic Atrophy Study Overview This study explores how retinal structure relates to visual function in geographic atrophy (GA). We focus on the connection between areas of vision loss (scotomas) and specific retinal features, particularly: Choroidal hypertransmission: A key sign of complete retinal pigment epithelium and outer retinal atrophy. Fundus autofluorescence (FAF): A…
Neurodevelopmental Outcomes After Nitric Oxide During Cardiopulmonary Bypass for Open Heart Surgery Study Overview This study looked at how adding nitric oxide (NO) during heart surgery affects the brain development of infants with congenital heart defects. The goal was to see if NO could help reduce inflammation and improve recovery. Key Details Participants: 1364 infants…
Cognitive Processing Therapy for PTSD in Japan Overview Cognitive Processing Therapy (CPT) is a proven treatment for posttraumatic stress disorder (PTSD). This study focuses on its effectiveness in Japan, where such evidence is limited. Study Purpose The goal was to determine if CPT effectively treats PTSD in outpatient settings in Japan. Study Design This randomized…
Neuroimaging Predictors of Successful Shunting in Hakim-Adams Syndrome Study Overview This study explores the effectiveness of cerebrospinal fluid shunting for patients with idiopathic normal pressure hydrocephalus. Over 15% of patients do not see improvement after surgery, prompting investigation into MRI predictors for better outcomes. Objective The goal was to compare a new MRI assessment model…
Effectiveness of Combined Therapy for Alcohol Use Disorder Study Overview This study explores how combining Attention Bias Modification (ABM) with Cognitive Behavioral Therapy (CBT) can help reduce relapse risk and cravings in men with Alcohol Use Disorder (AUD). Background AUD involves strong dependence on alcohol and difficulty controlling impulses. ABM helps individuals focus less on…
Comparison of Vitagnus, Soy, and Vitagnus-Soy Capsules for Premenstrual Syndrome Background Premenstrual syndrome (PMS) affects many women and can lower their quality of life. This study looked at how effective Vitagnus, soy, and a combination of both are in treating PMS among university students. Methods This study was a triple-blind clinical trial involving 108 students…