Mobile App Promoting Resilience in Stress Management for Adolescents and Young Adults With Cancer: Protocol for a Pilot Randomized Controlled Trial ABSTRACT Adolescents and young adults (AYAs) with cancer often face significant psychosocial challenges. This pilot randomized controlled trial (RCT) aimed to assess the feasibility, acceptability, and preliminary efficacy of a mobile app version of…
A Transtheoretical Model-Based Online Intervention for Medication Adherence in Chinese Adults with Type 2 Diabetes J Prim Care Community Health. 2024 Jan-Dec;15:21501319241263657 Background: Type 2 diabetes is on the rise in China, with medication non-adherence contributing to uncontrolled diabetes. This study aimed to use the Transtheoretical Model (TTM) in an online intervention to improve medication…
Impact of the COVID-19 Pandemic on CLEAR Outcomes Trial Key Findings: The CLEAR Outcomes Trial investigated the impact of bempedoic acid (BA) versus placebo in 13,970 patients with statin intolerance and high cardiovascular risk. BA reduced the risk of the primary endpoint (composite of CV death, nonfatal myocardial infarction, nonfatal stroke, or coronary revascularization) by…
Feasibility and accuracy of mobile QT interval monitoring strategies in bedaquiline-enhanced prophylactic leprosy treatment Highlights – Evaluation of alternative strategies for QT interval monitoring in settings where electrocardiographic monitoring is challenging – Use of mobile electrocardiogram (mECG) device and automated measurements in phase II randomized controlled BE-PEOPLE trial – 97% of recorded mECGs were of…
Identifying Oxytocin-Sensitive Autism Subtype Study Highlights and Practical Solutions Recent research has revealed that autism subtypes may respond differently to oxytocin treatment, with one subtype showing a significantly higher response rate (61.5%) compared to the other (13.3%). These findings suggest the potential for individualized oxytocin interventions to better target responsive subgroups. The study also identified…
Obesity Impact on Dyspnea in COPD Patients Background The study aimed to assess the impact of obesity on dyspnea in chronic obstructive pulmonary disease (COPD) patients and investigate the relationship between obesity and dyspnea severity in COPD. Methods 127 COPD patients with a BMI ≥ 18.5 kg/m² were included. Dyspnea was assessed using the mMRC…
Comparison between Reirradiation by Stereotactic Body Radiation Therapy and Moderately Hypofractionated Radiotherapy in Combination with Temozolomide for Treatment of Recurrent High Grade Glioma Objective: High grade glioma (HGG) often recurs and lacks a standard treatment. This study compared the effectiveness and side effects of two re-irradiation methods. Methods: Forty patients with recurrent HGG were divided…
Effect of Prostate Cancer Education on Saudi Men: Knowledge, Beliefs, and Screening Intentions Asian Pac J Cancer Prev. 2024 Jul 1;25(7):2439-2444. doi: 10.31557/APJCP.2024.25.7.2439. Abstract Purpose: This study aimed to assess the impact of a prostate cancer educational program on the knowledge, beliefs, and screening intentions of Saudi men. Methods: The study used a quasi-experimental design…
Mechanisms of Neurodynamic Treatments (MONET): Investigating Treatment for Carpal Tunnel Syndrome Study Overview The MONET study aims to understand how neurodynamic exercise interventions affect nerve structure and function in individuals with carpal tunnel syndrome (CTS). Study Design The study includes 78 CTS patients and 30 healthy participants. Patients are randomly assigned to a home-based exercise…
Impact of Combined Prebiotic Galacto-Oligosaccharides and Bifidobacterium breve-Derived Postbiotic on Gut Microbiota and HbA1c in Prediabetic Adults: A Double-Blind, Randomized, Placebo-Controlled Study ABSTRACT The study examined the effects of a 12-week dietary fiber supplement on gut health and metabolic function in prediabetic adults. The supplement contained konjac glucomannan (KGM), galacto-oligosaccharides (GOSs), and exopolysaccharides (EPSs) from…
Effects of Rehabilitative Exercise and Neuromuscular Electrical Stimulation on Muscle Morphology and Dynamic Balance in Individuals with Chronic Ankle Instability Summary Muscle atrophy due to chronic ankle instability (CAI) can lead to muscle weakness, altered movement patterns, and increased injury risk. This study investigated the effects of rehabilitative exercises and neuromuscular electrical stimulation (NMES) on…
Study of Two Sedative Protocols for Drug-Induced Sleep Endoscopy Practical Solutions and Value Obstructive sleep apnea (OSA) is a common condition with serious health impacts. While CPAP is the standard treatment, some patients cannot tolerate it. Drug-induced sleep endoscopy (DISE) helps evaluate airway obstruction and plan surgical treatment. Our study compared two sedation protocols for…
Effect of Diaphragmatic Breathing Exercises on Mental Fatigue and Upper Extremity Functions Key Findings This study explored the impact of mental fatigue induced by motor imagery on upper limb function. It found that mental fatigue can lead to decreased elbow flexion strength, hand grip strength, and upper extremity endurance, while also increasing tactile sensitivity. Intervention…
Aquatic Exercise and Type 2 Diabetes Study Overview A recent clinical trial compared the effects of aquatic and dry-land walking/running on blood glucose and plasma renin activity (PRA) in individuals with type 2 diabetes. The study found that both aquatic and dry-land sessions led to reductions in blood glucose levels, while only the aquatic session…
Study Title: Hippocampal Avoidance Whole-Brain Radiotherapy for Lung Cancer Brain Metastases Summary This study evaluated the effectiveness of a specific radiotherapy technique and cognitive testing in Chinese lung cancer patients with brain metastases. The results showed promising outcomes in terms of survival and cognitive function. Key Findings – The median survival for all patients was…
Study on Whitening Efficacy and Tooth Sensitivity of Hydrogen Peroxide Overview This study compared the effectiveness of using different concentrations of hydrogen peroxide gels with violet or blue LED light for teeth whitening and evaluated tooth sensitivity. Results Groups using higher concentration hydrogen peroxide with violet or blue LED showed better whitening results compared to…
Safety and Efficacy of High-Dose Inhaled Nitric Oxide for COVID-19 Viral Pneumonia Key Findings: • Intermittent 150-ppm iNO-treatment is well-tolerated, safe, and beneficial compared to usual care for spontaneously breathing hospitalised adults diagnosed with COVID-19 viral pneumonia. • Oxygen support duration was reduced by 2.7 days, a greater number of subjects reached oxygen saturation ≥…
Feasibility of Home-Based Testing for Acute Respiratory Viruses Key Findings: DETECT-AHEAD trial showed early feasibility of a decentralized program to prompt individuals to use a viral pathogen diagnostic test based on symptoms tracked in the study app or physiological changes detected using a wearable sensor. Practical Solutions: Our study demonstrated the potential for home-based diagnostic…
Phase 2 Study of NE3107 in Patients with Dementias Key Findings and Practical Solutions NE3107, an oral, anti-inflammatory, insulin-sensitizing molecule, showed positive effects in patients with mild cognitive impairment or mild dementia. Practical Solutions: NE3107 was associated with improvements in cerebral blood flow and brain functional connectivity. Patients showed improvements in cognitive assessments, including ADAS-Cog11,…
ER-Targeted PET for Initial Staging and Suspected Recurrence in ER-Positive Breast Cancer JAMA Netw Open. 2024 Jul 1;7(7):e2423435. doi: 10.1001/jamanetworkopen.2024.23435. Objective: To compare the detection rate of 16α-18F-fluoro-17β-estradiol (FES) positron emission tomography (PET) computed tomography (CT) with standard-of-care imaging (SOC) for staging locally advanced breast cancer (LABC) or evaluating suspected recurrence in ER-positive breast cancer.…