Practical Solutions for Reducing Cerebral Infarction Recurrence Study Overview To reduce the risk of cerebral infarction recurrence after cerebrovascular intervention, a clinical trial was conducted on 202 patients. The treatment group received clopidogrel doublet augmented antiplatelet therapy, while the control group received aspirin mono-antiplatelet therapy. Both groups continued the treatment for 2 months. Key Findings…
Effects of External Neuromuscular Electrical Stimulation in Women with Urgency Urinary Incontinence: A Randomized Sham-Controlled Study Background and Purpose The study aimed to investigate the effects of external neuromuscular electrical stimulation (NMES) on urinary symptoms, pelvic floor muscle strength (PFMS), quality of life (QoL), sexual function, perception of subjective improvement (PSI), and satisfaction in urgency…
Eyesi Direct Ophthalmoscope Simulator: Enhancing Fundus Examination Training Introduction Medical undergraduates often lack proper training in using direct ophthalmoscopes, leading to a shortage of basic ophthalmological skills among general practitioners worldwide. This study investigates the effectiveness of the Eyesi Direct Ophthalmoscope Simulator (Eyesi) as a modern tool for fundus examination training. Methods Undergraduates were randomly…
ROSELLA: Phase 3 Clinical Trial for Ovarian Cancer Key Findings and Practical Solutions Ovarian cancer is often diagnosed late and becomes resistant to chemotherapy. The ROSELLA study aims to improve outcomes for women with platinum-resistant ovarian cancer by using relacorilant, a selective GR modulator, in combination with nab-paclitaxel. The study includes women with recurrent, platinum-resistant,…
Health-related Quality of Life in Patients with Metastatic Basal Cell Carcinoma Treated with Cemiplimab: Analysis of a Phase 2 Trial Key Findings: A phase 2 study of cemiplimab showed a 24.1% objective response rate in patients with metastatic basal cell carcinoma who were not suitable for continued hedgehog inhibitor therapy. The study focused on assessing…
Efficacy of Type A Botulinum Toxin Treatment for Androgenetic Alopecia Objective This study aimed to assess the efficacy of type A botulinum toxin treatment for androgenetic alopecia (AGA) using a combination of ultrasound and trichoscopy. Methods Ninety patients with AGA were selected and received injections of type A botulinum toxin or a control agent. Ultrasound…
Comparing the Effectiveness of Behavioral Activation in Group vs. Self-Help Format for Reducing Depression: A Clinical Trial Key Findings: Behavioral Activation Group Therapy (BAGT) showed significant improvement in depression, rumination, work, and social functioning post-treatment and at the 2-month follow-up. 68% of BAGT participants were responsive to treatment, and 31% achieved a high final performance…
HEV Vaccine and Fetal Loss in Rural Bangladesh Practical Solutions and Value Vaccination is an important way to control hepatitis E virus (HEV), which is a significant cause of maternal and perinatal mortality worldwide. However, a study of pregnant women in Bangladesh receiving the HEV vaccine HEV239 showed a potential link to fetal losses. This…
Sequence of Morphological Changes Preceding Atrophy in Intermediate AMD Using Deep Learning ABSTRACT PURPOSE: Investigating the sequence of morphological changes preceding outer plexiform layer (OPL) subsidence, a marker preceding geographic atrophy, in intermediate AMD (iAMD) using high-precision artificial intelligence (AI) quantifications on optical coherence tomography imaging. METHODS: In this longitudinal observational study, individuals with bilateral…
Targeted Vibratory Therapy for Chronic Low Back Pain in Older Patients Introduction As people age, their proprioceptive function declines, leading to issues such as falls, pain, and difficulty in daily activities. This clinical trial aimed to investigate the effectiveness of targeted vibratory therapy (TVT) in improving proprioceptive function and alleviating chronic low back pain (LBP)…
Diagnosing Solid Lesions in the Pancreas With Multimodal Artificial Intelligence: A Randomized Crossover Trial Summary Artificial intelligence (AI) can help diagnose solid lesions in the pancreas from endoscopic ultrasonographic (EUS) images. This study developed a multimodal AI model integrating clinical information and EUS images to improve diagnosis. Key Findings The joint-AI model showed high performance…
Effects of Low-Dose Ketamine Infusion on Hopelessness and Suicidal Thoughts Background Low-dose ketamine infusion has been shown to reduce suicidal thoughts in patients with treatment-resistant depression (TRD) and strong suicidal ideation. However, its effects on hopelessness have been less studied. Methods 84 patients with TRD and strong suicidal ideation were randomly assigned to receive a…
High Flow Nasal Cannula Oxygen Therapy vs Non-Invasive Ventilation for COPD Key Findings A clinical trial compared high-flow nasal cannula oxygen therapy (HFNC) with non-invasive ventilation (NIV) for COPD patients with acute-moderate hypercapnic respiratory failure. The trial found that HFNC was not shown to be non-inferior to NIV and resulted in a higher incidence of…
Effect of Music Therapy Combined with Aerobic Exercise on Sleep Quality among Breast Cancer Patients BMC Womens Health. 2024 Jul 18;24(1):408 Purpose: This study aimed to investigate the impact of music therapy combined with aerobic exercise on the sleep quality of breast cancer patients undergoing chemotherapy after a radical mastectomy. Methods: A randomized controlled trial…
Community Case Detection Tool for Mental Health Care in Ugandan Refugee Settlements: Clinical Trial Results Background Strategies to promote mental health care help-seeking among children are crucial, especially in low-income and complex settings. This trial aimed to compare a proactive case detection tool (CCDT) against standard awareness raising for promoting mental health help-seeking among children…
Assessing the Clinical Effectiveness of Exergame-Based Exercise Training Program Using Ring Fit Adventure for Older Adults in Long-Term Care Facilities Background Frailty and sarcopenia are common among older adults in long-term care facilities (LTCFs) and can lead to health issues. Implementing exercise programs in LTCFs, especially in rural areas, can be challenging due to staff…
Ritlecitinib: A Breakthrough in Vitiligo Treatment Published in Arch Dermatol Res, a clinical trial showed that ritlecitinib, an oral JAK3/TEC family kinase inhibitor, significantly stabilized active lesions and repigmented stable lesions in patients with non-segmental vitiligo. Key Findings: Ritlecitinib 50 mg demonstrated significant stabilization of depigmentation extent in both active and stable lesions compared to…
Emollient application from birth to prevent eczema in high-risk children: the BEEP RCT Practical Solutions and Value Highlights Atopic eczema is a common childhood skin problem connected with asthma and allergies, affecting quality of life. The study aimed to determine if advising parents to apply daily emollients in the first year can prevent eczema and…
The effects of regular home delivery of HIV self-testing and follow-up counselling on HIV testing and prevention outcomes in men who have sex with men who test infrequently in the United States: a pragmatic, virtual randomized controlled trial J Int AIDS Soc. 2024 Jul;27(7):e26318. doi: 10.1002/jia2.26318. INTRODUCTION: Research has shown that HIV self-testing (HIVST) can…
The Role of Vitamin D in Management of Oral Lichen Planus Background and Objectives Oral lichen planus (OLP) is an immune-mediated inflammatory disease affecting the oral mucosa. Vitamin D (VD) has been studied for its potential immune-modulatory and anti-inflammatory effects in managing OLP. This study aimed to investigate the role of VD in the management…