Low Pressure versus Standard Pressure Pneumoperitoneum in Laparoscopic Appendectomy: A Randomized Controlled Trial Key Findings The use of low pressure pneumoperitoneum did not reduce the incidence of abdominal pain in patients who had laparoscopic appendectomy. Patients with acute appendicitis can be treated with either low or normal pressure pneumoperitoneum depending on the experience of the…
Efficacy and Safety of Combination Therapy for Schistosomiasis in Kenyan Children Introduction Reliance on praziquantel for treating schistosomiasis may lead to drug resistance. We evaluated the efficacy and safety of combining praziquantel with artesunate plus sulfalene-pyrimethamine in Kenyan children with schistosomiasis. Methods 426 children aged 7-15 were randomly assigned to receive praziquantel alone, artesunate plus…
Empagliflozin Reduces Ventricular Arrhythmias in Type 2 Diabetes Patients Study Overview Sodium-glucose cotransporter 2 (SGLT2) inhibitors like empagliflozin have shown benefits in reducing heart failure and cardiovascular death in type 2 diabetes patients. This study aimed to investigate the effects of empagliflozin on ventricular arrhythmias in patients with type 2 diabetes who were treated with…
Exploring the Impact of Link Workers on Multimorbidity in Deprived Communities Overview An exploratory trial was conducted to assess the feasibility, impact, and cost effectiveness of using link workers to connect individuals with multiple health conditions to non-clinical supports in deprived urban communities. The study aimed to evaluate the benefits of this approach on health…
Anti-dsDNA IgE: a Potential Non-Invasive Test for Prediction of Lupus Nephritis Relapse RMD Open. 2024 Jun 28;10(2):e004255. doi: 10.1136/rmdopen-2024-004255. Objectives: The WIN-IgE study aims to assess the value of serum anti-dsDNA IgE autoantibodies as a biomarker for predicting relapse in severe lupus nephritis (LN) to guide the discontinuation or continuation of maintenance immunosuppressive therapy (MIST).…
Hydromorphone combined with ropivacaine for erector spinae plane block in patients undergoing modified radical mastectomy: A prospective randomized controlled trial Medicine (Baltimore). 2024 Jun 28;103(26):e38758. doi: 10.1097/MD.0000000000038758. Background: Combining hydromorphone with ropivacaine in ultrasound-guided erector spinae plane blocks enhances postoperative pain relief and reduces interleukin-6 expression in breast surgery patients. Methods: Breast cancer patients undergoing…
Prospective, Randomised Clinical Trial on Silicone Intubarium Necessity in Endonasal-Endoscopic Dacryocystorhinostomy (EN-DCR) Background This study evaluates the impact of using a silicone stent tube (SST) on the success of EN-DCR for treating primary acquired nasolacrimal duct obstruction. Methods Patients were randomly assigned to receive EN-DCR with or without SST intubation. The surgery was performed using…
Clinical Trial: Efficacy of Sivelestat in Treating Sepsis Patients with ARDS and SCM Background Researchers assessed the effectiveness of sivelestat, a neutrophil elastase inhibitor, in treating sepsis-induced acute respiratory distress syndrome (ARDS) and septic cardiomyopathy (SCM). Methods A randomized trial was conducted on patients diagnosed with sepsis-induced ARDS and SCM at Wuhan Union Hospital. The…
Developing a Fit-for-Purpose Composite Symptom Score for Malignant Pleural Mesothelioma Clinical Trials Key Practical Solutions and Value We developed a composite symptom score (CSS) to measure disease-related symptom burden in patients with malignant pleural mesothelioma (MPM). The CSS, derived from the MD Anderson Symptom Inventory for MPM, includes 5 symptoms: pain, fatigue, shortness of breath,…
Clinical Trial Results: Afatinib in Metastatic Esophageal Squamous Cell Carcinoma Key Findings: Preclinical data demonstrated promising antitumor activity of afatinib in EGFR-overexpressing ESCC. Phase II trial showed a confirmed objective response rate (ORR) of 39% and a median overall survival of 7.8 months in pretreated metastatic ESCC patients with EGFR overexpression. Transcriptome analysis revealed a…
Local Radiotherapy and Measurable Residual Disease-Driven Immunotherapy in Early-Stage Follicular Lymphoma (FIL MIRO) Trial: Final Results Practical Solutions and Value Highlights: Local radiotherapy and anti-CD20 monoclonal antibody (mAb) treatment were evaluated using a measurable residual disease (MRD)-driven approach. Patients with early-stage follicular lymphoma were initially treated with radiotherapy, and those still MRD-positive received anti-CD20 mAb…
Phase II Study of Ulixertinib in Children and Young Adults With Tumors Harboring Activating Mitogen-Activated Protein Kinase Pathway Alterations: APEC1621J of the National Cancer Institute-Children’s Oncology Group Pediatric MATCH Trial Summary The National Cancer Institute-Children’s Oncology Group (NCI-COG) Pediatric MATCH trial tested ulixertinib, a targeted therapy, in patients aged 1-21 with refractory malignancies harboring genetic…
Effectiveness of Eccentric Load in Upper Limb Injury Rehabilitation Practical Solutions and Value The study aimed to assess the effectiveness of therapeutic exercises with eccentric muscle loads in rehabilitating patients with upper limb injuries. This is particularly relevant for athletes, elderly individuals, and those with an active lifestyle. Patients were divided into two groups: one…
Efficacy and Viability of Subgingival Application of Probiotics as an Adjunct to Scaling and Root Planing in Periodontitis Summary This study compared the effectiveness of applying probiotics under the gums along with scaling and root planing (SRP) versus SRP alone in patients with periodontitis. Key Findings Patients who received probiotics in addition to SRP showed…
Practicing Interoceptive Sensitivity as a Couple A Mixed-Methods Acceptance Analysis of a Dyadic vs. Single Pilot Randomized Controlled Trial Interoceptive sensitivity (IS) training is a step toward promoting intuitive eating (IE). A pilot randomized controlled trial was conducted among couples aged 50+ to increase IE. The trial involved three exercises: Body Scan (BS), hunger exercise…
Silymarin Supplementation in Active Rheumatoid Arthritis: Pilot Study Results Background and Objectives Coadministration of silymarin, a natural supplement, with conventional antirheumatic drugs is of interest in treating active rheumatoid arthritis. This study aimed to evaluate the impact of silymarin supplementation on patients’ disease activity and overall condition. Materials and Methods 122 patients with active rheumatoid…
Reframing Communication about Fall Prevention Programs to Increase Older Adults’ Intentions to Participate ABSTRACT Falls and fall-related injuries in community-dwelling older adults are a growing global health concern. Despite effective exercise-based fall prevention programs (FPPs), low enrollment rates persist due to negative connotations associated with falls and aging. This study aimed to investigate whether positive…
Colchicine in Patients with Acute Ischaemic Stroke or Transient Ischaemic Attack (CHANCE-3) Key Findings The study aimed to determine the effectiveness and safety of colchicine in reducing the risk of subsequent stroke after high risk non-cardioembolic ischaemic stroke or transient ischaemic attack within the first three months of symptom onset. Study Design This was a…
Digital Cognitive-Behavioural Therapy vs. Zolpidem for Insomnia Treatment BMJ Open. 2024 Jun 25;14(6):e081205 Introduction: Insomnia is a common health issue, and cognitive-behavioural therapy (CBT) is a recommended treatment. Due to a shortage of CBT-trained therapists, we developed a digital CBT application (IIIP MED: Sleepy Med) for insomnia. This study outlines an exploratory trial to assess…
Unified Protocol Versus Self-Acceptance Group Therapy for Emotional Disorders in People With Severe Shame ABSTRACT Severe shame is a distressing negative emotion linked to various psychological disorders. A study compared the effects of two treatments, the Unified Protocol (UP) and Self-Acceptance Group Therapy (SAGT), on shame dysregulation in individuals with emotional disorders, including borderline personality…