Tunica Vaginalis vs. Dartos Flap for Penile Hypospadias Purpose This study compares two methods—dartos flap (DF) and tunica vaginalis flap (TVF)—used to cover the urethra in children with distal or mid-shaft penile hypospadias after surgery. Methods The trial involved 88 children, excluding those with previous surgeries like orchiectomy or hernia repair. They were randomly assigned…
Oxytocin Levels in Patients with Hypopituitarism and Hypothalamic Damage Study Overview This study investigates oxytocin deficiency in patients with hypopituitarism and hypothalamic damage. This deficiency is linked to mental health issues and sexual problems, affecting overall quality of life. Key Findings Purpose: To test if corticotropin-releasing hormone (CRH) can trigger oxytocin release in these patients.…
Posttreatment Blood Pressure: A Key Predictor for Stroke Risk Study Overview Research shows that 63.0%-84.2% of stroke survivors have high blood pressure (hypertension). However, there is no specific tool to predict stroke risk for those with hypertension. We used data from 20,702 hypertensive patients in the China Stroke Primary Prevention Trial (CSPPT) to create a…
Postprandial Glycaemic Response and Pain Sensitivity in Breast Cancer Survivors Study Overview: This study examines how different drinks affect blood sugar levels in breast cancer survivors with chronic pain compared to healthy individuals. Key Objectives: Main Goal: Compare blood sugar responses to drinks with low and medium glycaemic indexes. Secondary Goal: Explore the relationship between…
Effects of Aquatic vs. Land-Based Exercise on Older Adults with Sarcopenia Introduction Sarcopenia is a common condition in older adults that leads to muscle loss. While various exercises can help, there is limited research on how different environments, like water versus land, affect sarcopenia. This study aims to compare the effects of aquatic exercise and…
Detection of Elder Abuse Through Emergency Care Technicians Screening Tool Revision for Home-Based Primary Care (DETECT-RPC) Study Overview The prevalence of elder mistreatment (EM) is concerning, especially among older adults with Alzheimer’s disease and related dementias, where it can be as high as 75%. EM significantly impacts quality of life and increases mortality risk. Home-based…
Effects of Tongue Tamers and Customized Bonded Spurs for Anterior Open Bite Treatment Background Anterior open bite is a common issue for children that can affect their appearance, speech, eating, and emotional well-being. Early diagnosis and treatment are essential. Aim This study investigates how effective prefabricated metal-bonded tongue tamers and customized bonded spurs are for…
Supporting Community Lung Cancer Screening A web-based decision aid to help informed decision making Background The National Lung Screening Trial offers the promise of reducing lung cancer deaths. However, getting communities engaged in lung cancer screening (LCS) has been difficult. New policies encourage shared decision-making and using tools to help people make informed choices about…
Olaparib for Ovarian Cancer Treatment: Key Findings from the LIGHT Study Background The LIGHT study evaluated the effectiveness of olaparib for patients with platinum-sensitive relapsed ovarian cancer (PSROC). Patients were grouped based on their BRCA mutation and homologous recombination deficiency (HRD) status. The study found that olaparib worked well in all groups, particularly in those…
Cost-Utility and Cost-Benefit Analysis of NEXpro for Neck Pain in Office Workers Background Neck pain is a major health issue for office workers, affecting 42% to 68% of them. This study looked at the costs and benefits of a program called NEXpro, which includes neck exercises, health workshops, and ergonomic training over 12 weeks. Methods…
Exercise Duration and Health Benefits for Young Women Study Overview This study investigates how different durations of aerobic exercise impact young women’s health, focusing on insulin sensitivity and cardiovascular performance. The key findings highlight the importance of exercising for eight weeks compared to just four weeks. Key Findings Duration Matters: Eight weeks of moderate-intensity aerobic…
The Efficacy and Safety of Thymosin Alpha1 for Sepsis (TESTS) Study Overview This study aimed to see if thymosin α1 can lower death rates in adults with sepsis. Study Design This was a phase 3 trial conducted at 22 centers in China from September 2016 to December 2020. It was double-blinded and placebo-controlled. Participants A…
Study on PEG-rhG-CSF for Preventing Neutropenia in Nasopharyngeal Carcinoma Background This study examines how effective and safe Polyethylene glycolated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) is in preventing neutropenia during concurrent chemoradiotherapy for nasopharyngeal carcinoma (NPC). Methods Conducted from June 1, 2021, to October 31, 2022, this single-center study involved patients with locally advanced NPC.…
Low-Intensity Online Intervention for Mental Distress Among Young People in Hong Kong Study Overview This study looks at the mental health issues faced by young people in Hong Kong. Traditional therapy methods often struggle due to a lack of staff, time constraints, and low participation rates. Objective The goal was to assess how effective a…
Pain Control After Laparoscopic Appendicectomy in Children Study Overview This study compares two methods of pain control after laparoscopic appendicectomy in children: Laparoscopic-assisted Transversus Abdominus Plane block (L-TAP) and port site infiltration (PSI). It aims to find out which method is more effective in reducing pain and hospital stay. Key Findings Participants: 49 patients received…
Vedolizumab Study in Ulcerative Colitis Background Ulcerative colitis (UC) is a long-term inflammatory disease that needs ongoing treatment and monitoring. There is not much information about how vedolizumab works during maintenance therapy and how thiopurines affect its levels. Aim This study aimed to understand how vedolizumab levels relate to treatment outcomes and what happens when…
18F-Prostate-Specific Membrane Antigen PET/CT Imaging for Pancreatic Cancer (PANSCAN-2) Study Overview This study explored the use of 18F-PSMA PET/CT imaging to detect potentially resectable pancreatic cancer, specifically pancreatic ductal adenocarcinoma (PDAC). Current imaging methods struggle to distinguish between cancerous and non-cancerous pancreatic conditions and often miss lymph node metastases. Study Details Seventeen patients with resectable…
Home-Use Agents for Dentin Hypersensitivity Treatment Study Overview This study evaluated how effective home-use desensitizing agents are over an 8-week period. Different measurement methods were used to compare their effectiveness. Research Details A clinical trial involved 180 participants aged 18 to 70 with diagnosed dentin hypersensitivity (DH). Out of these, 164 individuals met the criteria…
Electronic Patient-Reported Outcome System in Cardiovascular Care Importance Patient-reported outcomes (PRO) are important for cardiovascular care, but their use has faced significant challenges. Objective This study aimed to evaluate how an electronic PRO (ePRO) monitoring system can improve the quality of cardiovascular care. Study Overview This pilot randomized clinical trial took place in Japan from…
Effectiveness of Potent Topical Corticosteroids for Children with Atopic Dermatitis Study Overview This study evaluated how effective a strong topical corticosteroid (TCS) is compared to a mild one for treating moderate flare-ups of atopic dermatitis (AD) in children. The research was conducted in primary care settings. Study Details Design: Observational cohort study with a randomized…