Cost-effectiveness of Talazoparib for Advanced Breast Cancer Key Findings: Talazoparib, a targeted PARP inhibitor, has shown significant extension in progression-free survival and improved response markers for patients with germline BRCA1/2 mutated HER2-negative advanced breast cancer, compared to conventional therapies. Practical Solutions: Our analysis aims to assess the cost-effectiveness of talazoparib in treating advanced breast cancer…
Lateral Episiotomy in Vacuum Assisted Delivery for First-Time Mothers Objective To compare the effect of lateral episiotomy versus no episiotomy on obstetric anal sphincter injury in first-time mothers requiring vacuum extraction. Study Design A multicentre, open label, randomised controlled trial conducted in eight hospitals in Sweden from 2017 to 2023. Participants 717 first-time mothers with…
Assessing the Impact of Jail-Initiated Medication for Opioid Use Disorder: A Multisite Analysis of the SOMATICS Collaborative Objective The objective of this study was to assess the effects of jail-initiated medication for opioid use disorder (MOUD) and patient navigation (PN) on opioid use disorder (OUD) at 6 months post-release. Study Details Three randomized trials (combined…
Cost-Effectiveness Analysis of Bevacizumab Combined with Lomustine in the Treatment of Progressive Glioblastoma Key Findings Compared to Lomustine alone, the combination of Bevacizumab and Lomustine increased the total treatment cost from $2,646.70 to $23,650.98. The health-adjusted life years (QALYs) for the combination therapy increased from 0.26 QALYs to 0.51 QALYs, representing an increment of 0.25…
Characterization of Anti-Drug Antibody Responses to Cibisatamab Practical Solutions and Value An appropriately designed pharmacokinetic (PK) assay sensitive for anti-drug antibody (ADA) impact on exposure is an alternative strategy to understand the neutralizing potential of ADAs. The PK assay of cibisatamab, a T-cell-engaging bispecific antibody, was developed based on its mechanism of action (MoA). Using…
Short-term effects of gastric bypass versus sleeve gastrectomy on high LDL cholesterol: The BASALTO randomized clinical trial ABSTRACT There has been a substantial increase in the use of laparoscopic sleeve gastrectomy (SG) to treat morbid obesity despite observational evidence demonstrating the superiority of Roux-en-Y gastric bypass (RYGB) for reducing low-density lipoprotein (LDL) cholesterol. The main…
Effectiveness of Fractional Erbium-YAG Laser, Microneedling, Platelet-Rich Plasma in Localized Stable Vitiligo Patients: Randomized Clinical Trial ABSTRACT Vitiligo is a challenging autoimmune disease to treat. This study compared the effects of fractional erbium:yttrium-aluminum-garnet (Er:YAG) laser-assisted delivery of platelet-rich plasma with microneedling (Mn) and platelet-rich plasma (PRP) in enhancing skin repigmentation in localized stable vitiligo patients.…
Study Results: Impact of Online Educational Seminar on Systemic Sclerosis Patients Key Findings: An online, two-day educational seminar showed a small increase in disease-specific knowledge among systemic sclerosis (SSc) patients. The seminar resulted in a measurable, but not statistically significant, increase in knowledge. Being a member of a self-help group was found to be a…
Effectiveness of a Novel Diet in Ulcerative Colitis Patients Key Findings: A combined Mediterranean, low-FODMAP diet with partial enteral nutrition (PEN) significantly reduced disease activity index and improved quality of life in patients with ulcerative colitis (UC). The diet also led to a significant decrease in serum level of high sensitive C-reactive protein (hs-CRP) and…
Effects of Routine Physical Therapy with and without Kinesio Taping in Improving Gross Motor Function in Spastic Diplegic Cerebral Palsy Children Objective To determine the effectiveness of Kinesio taping along with routine physical therapy on improving gross motor function in sitting and standing among spastic diplegic Cerebral Palsy children. Design Randomized controlled trial. Participants 53…
Efficacy and Safety of Atropine and Orthokeratology Lens in Delaying Juvenile Myopia Key Findings: A study investigated the effectiveness and safety of combining low-concentration Atropine with orthokeratology (OK) lens in delaying juvenile myopia. The study included 172 adolescents aged 8 to 12 years over a period from April 2021 to May 2022. The results showed…
Positive Effect of Self-Exercise Following Botulinum Toxin Injection on Recovery in HFS and BFS Patients: Clinical Trial ABSTRACT Botulinum toxin (BoNT) injection is the main treatment for hemifacial spasm (HFS) and blepharospasm (BFS). However, its long-term effectiveness is uncertain. This study investigates whether self-exercise after BoNT injection can prolong its effectiveness. METHODS 51 volunteers with…
Comparison of Yoga with Exercise in Ankylosing Spondylitis on Mobility and Functional Capacity Abstract To compare the effects of Yoga with traditional exercise on the mobility and functional capacity of individuals with ankylosing spondylitis (AS). Methods The study recruited participants from the rheumatology department based on specific criteria and randomized them into two groups: Group…
Study Overview Title: Is the addition of running retraining to best standard care beneficial in runners with medial tibial stress syndrome? Protocol for a randomised controlled trial Journal: J Foot Ankle Res. 2024 Jun;17(2):e12029 DOI: 10.1002/jfa2.12029 Background Running retraining is commonly used in the management of medial tibial stress syndrome (MTSS) but evidence for its…
Assessing the Impact of Artificial Intelligence in Outpatient Triage Study Overview Our study evaluated the effectiveness of ChatGPT, an AI-powered natural language processing tool, in outpatient triage. We presented 30 common outpatient questions to ChatGPT and scored its responses with the help of experienced doctors. Key Findings The evaluation revealed that ChatGPT provided highly professional,…
The iTAPP Study: Evaluating the 15-Method in Primary Care Practical Solutions and Value Background: The 15-method is a proven approach for alcohol problems in primary care, as effective as specialized treatment for mild to moderate alcohol dependence in Sweden. A feasibility study in Danish primary care found the method acceptable and feasible. Aims: Evaluate the…
Emotional Awareness and Expression Therapy vs Cognitive Behavioral Therapy for Chronic Pain in Older Veterans: A Randomized Clinical Trial Overview Chronic pain is common and disabling in older adults, and psychological interventions are indicated. However, the gold standard approach, cognitive-behavioral therapy (CBT), produces only modest benefits, and more powerful options are needed. Study Details The…
Theoretical Explanation of the Benefits of a Nutrition Counseling and Meal Delivery Program for Lung Cancer Patients Study Overview A study was conducted to understand how a medically tailored meal delivery program and intensive nutrition counseling helped individuals with lung cancer. The study involved interviews with participants from four cancer centers in the USA. Findings…
Impact of Telemedical Management on Heart Failure Patients with Diabetes Key Findings from the TIM-HF2 Trial The TIM-HF2 study showed that remote patient management (RPM) reduced hospital admissions and mortality in heart failure (HF) patients. This post-hoc analysis focused on HF patients with diabetes, who are at higher risk. Practical Solutions and Value: RPM decreased…
Efficacy and Safety of Transcutaneous Electrical Acupoint Stimulation for Primary Dysmenorrhoea Overview Primary dysmenorrhoea (PD) causes significant physical and psychosocial impacts. This study aims to assess the effectiveness and safety of transcutaneous electrical acupoint stimulation (TEAS) in managing PD symptoms. Study Design 60 participants with moderate to severe PD will be recruited and randomly assigned…