Patient enrollment
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseThe effects of dietary protein on physical performance and body composition in middle age and older people having type II diabetes mellitus: a randomized pilot study
The Effects of Dietary Protein on Physical Performance in Older Adults with Type 2 Diabetes Study Overview This study looked at how increasing dietary protein can help older adults with type 2 diabetes. The goal was to see if more protein can improve muscle mass, strength, and physical performance. Study Method In a 12-week study, […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseMetastatic sites of baseline as predictors in recurrent or metastatic nasopharyngeal carinoma treated with PD-L1 inhibitor: a secondary analysis of multicenter, single-arm, phase II study (KL-A167)
Study Overview This study examines how the location of metastatic sites affects the treatment outcomes of recurrent or metastatic nasopharyngeal carcinoma (R/M NPC) patients receiving a PD-L1 inhibitor called KL-A167. Key Findings Patient Demographics: 153 patients were studied, with an average age of 47 years; 81% were male. Metastatic Sites: Most patients had distant metastasis, […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseClinical Manifestations
Clinical Manifestations Study Overview This study looked at how well computerized cognitive training (CCT) works when combined with selective serotonin reuptake inhibitors (SSRIs) for patients with late-life depression (LLD). Method The research took place from May 5, 2021, to April 21, 2023. Patients diagnosed with major depressive disorder were divided into two groups: CCT and […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseClinical Manifestations
Clinical Manifestations Background Cognitive issues affect about 40% of people with heart failure (HF). This study looks at how patients with HF view their cognitive abilities and how these views relate to actual cognitive performance. Method We used initial data from a randomized controlled trial involving 73 HF patients to test a cognitive intervention aimed […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseComparative immunogenicity assessment of biosimilar natalizumab to its reference medicine: a matching immunogenicity profile
Comparative Immunogenicity of Biosimilar Natalizumab Overview Biosimilar natalizumab (biosim-NTZ) is the first biosimilar version of the original natalizumab (ref-NTZ) used to treat relapsing forms of multiple sclerosis (MS). This study aimed to confirm that biosim-NTZ has a similar immunogenicity profile to ref-NTZ. Study Methods Two key clinical studies were conducted: Efficacy and Safety Study: 264 […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Zanubrutinib plus R-CHOP for the treatment of newly diagnosed double-expressor lymphoma: A phase 2 clinical study
Zanubrutinib plus R-CHOP for Double-Expressor Lymphoma Study Overview This study focuses on double-expressor lymphoma (DEL), which has a worse outlook than other types of diffuse large B-cell lymphoma (DLBCL). It evaluates the effectiveness and safety of combining zanubrutinib with the R-CHOP treatment (which includes rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) for patients with DEL at […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseModulation of hormonal, metabolic, inflammatory and oxidative stress biomarkers in women with polycystic ovary syndrome following combined (resistant and endurance) training: a randomized controlled trail
Modulation of Hormonal, Metabolic, and Inflammatory Biomarkers in Women with PCOS Study Overview Polycystic Ovary Syndrome (PCOS) is a common condition among women. Exercise is known to help, but there’s limited research on the best types of exercise. This study looked at how combined training (both resistance and endurance) affects various health markers in women […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseHydroxychloroquine enhances insulin sensitivity and ameliorates abnormal lipid metabolism in obese women with polycystic ovary syndrome
Hydroxychloroquine Improves Health in Obese Women with PCOS Study Overview Hydroxychloroquine (HCQ) is commonly used for immune disorders and shows promise in helping obese women with polycystic ovary syndrome (PCOS) by lowering blood sugar levels. However, how it works is still not fully understood. Study Purpose This study aimed to see how HCQ affects blood […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseUse of a Personalized Clinical Decision Support System for Dosing in Psychopharmacotherapy in Patients with Alcoholic Hallucinosis Based on Pharmacogenomic Markers
Use of a Personalized Clinical Decision Support System for Dosing in Psychopharmacotherapy in Patients with Alcoholic Hallucinosis Based on Pharmacogenomic Markers Introduction Alcoholic hallucinosis (AH) is a serious issue related to chronic alcoholism, causing symptoms like auditory hallucinations and delusions. Haloperidol is a common treatment, but it often has side effects. By using pharmacogenetic testing, […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseOptical molecular imaging in oral- and oropharyngeal squamous cell carcinoma using a novel uPAR-targeting near-infrared imaging agent FG001 (ICG-Glu-Glu-AE105): An explorative phase II clinical trial
Optical Molecular Imaging in Oral and Oropharyngeal Cancer Study Overview This study focuses on a new imaging agent, FG001, designed to improve the detection of oral and oropharyngeal squamous cell carcinoma (OSCC, OPSCC) during surgery. Accurate identification of cancerous tissue is crucial for better patient outcomes. Trial Details We conducted a phase II clinical trial […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Text Messaging Versus Postal Reminders to Improve Participation in a Colorectal Cancer Screening Program: Randomized Controlled Trial
Text Messaging Versus Postal Reminders for Colorectal Cancer Screening Study Overview This study compared the effectiveness of SMS text message reminders to traditional postal reminders for increasing participation in a colorectal cancer screening program in Catalonia, Spain. Key Findings Participants: Individuals aged 50 to 69 who were invited for screening but hadn’t completed their tests. […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseThe Effect of Stress Ball on Anxiety and Pain Levels in Angiography: A Randomized Controlled Trial
The Effect of Stress Ball on Anxiety and Pain Levels in Angiography: A Randomized Controlled Trial Background Coronary angiography is a procedure that can cause pain and anxiety in patients. Using stress balls as a simple tool to help reduce discomfort has not been studied much. Objective This study aims to see if using stress […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseCardiopulmonary Exercise Testing-Guided Exercise Therapy in Hypertensive Patients: A Single Center Study
Cardiopulmonary Exercise Testing-Guided Exercise Therapy in Hypertensive Patients Study Overview This study looked at how exercise therapy, guided by cardiopulmonary exercise testing (CPET), affects patients with high blood pressure. It focused on improving heart and lung function, blood pressure control, and cholesterol levels. Key Findings Participants: 67 patients with Grade 1 hypertension on medication. Groups: […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseSynovitis scoring in hand osteoarthritis with ultrasonography: the performance of the Global OMERACT/EULAR Ultrasound Synovitis Score (GLOESS) is comparable to synovial thickening alone
Ultrasound Scoring in Hand Osteoarthritis Study Overview This study looked at how well the Global OMERACT/EULAR Ultrasound Synovitis Score (GLOESS) measures inflammation in hand osteoarthritis (OA) compared to just looking at synovial thickening. Key Findings Inflammation is a key target for treating hand OA. The study used data from the HOPE trial, which involved patients […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Impaired coagulation parameters in early RA are restored by effective antirheumatic therapy: a prospective pilot study
Impaired Coagulation in Early RA Improved by Antirheumatic Therapy Study Overview This study looks at how treatment affects blood clotting in patients newly diagnosed with rheumatoid arthritis (RA). Key Findings Patient Treatment: Patients started on methotrexate and were randomly assigned to receive either additional conventional treatment, certolizumab pegol, abatacept, or tocilizumab. Biomarkers Analyzed: Various blood […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffect of behavior modification combined with health belief model education on adherence to skin moisturizing care in patients with psoriasis vulgaris
Impact of Education and Behavior Change on Psoriasis Care This study explored how combining education with behavior modification affects skin care in patients with psoriasis vulgaris. Study Overview A total of 108 patients participated from November 2022 to October 2023. They were divided into two groups: Control Group: Received standard care, including medication advice and […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Exploratory testing of functional blood oxygenation level dependent-MRI to image the renoprotective effect of Remote Ischaemic PreConditioning during partial nephrectomy
Exploratory Testing of MRI for Renal Protection During Surgery Study Overview This study explores the use of Blood Oxygenation Level Dependent-MRI (BOLD-MRI) to measure the protective effects of Remote Ischaemic PreConditioning (RIPC) during partial nephrectomy surgery. RIPC involves temporarily restricting blood flow to the limbs to safeguard the kidneys during the procedure. Key Findings 15 […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseSafety and tolerability of the M2 muscarinic acetylcholine receptor modulator BAY 2413555 in heart failure with reduced ejection fraction in the REMOTE-HF study
Study Overview BAY 2413555 is a new treatment aimed at improving heart function in patients with heart failure (HF). This study focused on its safety, tolerability, and how the body processes it. Key Details of the Study The study was called REMOTE-HF and included multiple centers. It was a double-blind, placebo-controlled trial. Participants had HF […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseAxillary Lymph Node Dissection versus Loco-regional Radiotherapy in Management of the Axilla in Node-Negative Locally Advanced Breast Cancer Post Neoadjuvant Chemotherapy
Axillary Lymph Node Dissection vs. Loco-regional Radiotherapy in Breast Cancer Treatment Background Recent years have seen major changes in how we manage the axilla (underarm area) in breast cancer treatment. The goal is to reduce surgery while still ensuring effective treatment and accurate diagnosis for patients. Advances in additional therapies have made this possible. Objective […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseJAK inhibition decreases the autoimmune burden in Down syndrome
JAK Inhibition Reduces Autoimmune Issues in Down Syndrome Overview Individuals with Down syndrome (DS), caused by an extra chromosome 21, often face immune system challenges, including high autoimmunity rates and serious infections. This study explores how these immune issues relate to DS and how JAK inhibitors might help. Study Methods We conducted a detailed analysis […] ➡️➡️➡️