Patient enrollment
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseHealth economic evaluation alongside randomised clinical trial of a health behaviour intervention to manage type 2 diabetes in Nepal
Health Economic Evaluation of a Diabetes Intervention in Nepal Background Type 2 diabetes prevention is a major health issue in low and middle-income countries like Nepal. This study looked into the cost-effectiveness of a health behaviour intervention compared to regular care for managing diabetes in a community setting. Methods We randomly assigned 30 groups of […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Patient-reported outcomes of rezvilutamide versus bicalutamide in combination with androgen deprivation therapy in high-volume metastatic hormone-sensitive prostate cancer patients (CHART): a randomized, phase 3 study
Study on Rezvilutamide vs. Bicalutamide for Prostate Cancer Overview The CHART trial (NCT03520478) was a phase 3 study comparing rezvilutamide (REZ) with bicalutamide (BIC) in patients with high-volume metastatic hormone-sensitive prostate cancer (mHSPC) receiving androgen deprivation therapy (ADT). The study found that REZ combined with ADT led to better survival rates and less disease progression […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseRelationship Between Severity of Ischemia and Coronary Artery Disease for Different Stress Test Modalities in the ISCHEMIA Trial
Understanding the ISCHEMIA Trial Findings Background The ISCHEMIA Trial explored how stress-induced ischemia relates to coronary artery disease (CAD) severity. Factors influencing this relationship include: Intensity of stress during testing Type of stress test used History of heart attacks Blood flow from collateral vessels Characteristics of plaque Microvascular health Coronary blood vessel tone Genetic factors […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseImmediate effects of Kinesio taping on pain, proprioception, and posture in round shoulder individuals with subacromial impingement syndrome: A randomized, double-blinded controlled trial
Immediate Effects of Kinesio Taping on Pain, Proprioception, and Posture Background Round shoulder posture (RSP) occurs when shoulders are positioned forward due to weak and tight muscles. This can lead to Subacromial Impingement Syndrome (SIS), causing pain during certain movements. This study looks at how Kinesio taping (KT) affects pain, body awareness (proprioception), and posture […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffect of Low- and Moderate-Intensity Aerobic Training on Body Composition Cardiorespiratory Functions, Biochemical Risk Factors and Adipokines in Morbid Obesity
Effect of Aerobic Training on Obesity Background Obesity is a major health issue worldwide, leading to various health problems, including heart disease. This study looks at how low- and moderate-intensity aerobic training can affect body composition and health markers in severely obese patients. Methods Forty severely obese patients participated in a six-week study. They were […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffects of Synbiotic Supplementation on Bone and Metabolic Health in Caucasian Postmenopausal Women: Rationale and Design of the OsteoPreP Trial
Effects of Synbiotic Supplementation on Bone and Metabolic Health in Postmenopausal Women Overview This study explores how a synbiotic supplement can help improve bone and metabolic health in Caucasian postmenopausal women. The OsteoPreP trial will last for 12 months and aims to see if this supplement can prevent bone loss and improve overall health. Study […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEfficacy of ETB-F01, Heat-Killed Akkermansia muciniphila Strain EB-AMDK19, in Patients with Respiratory Symptoms: A Multicenter Clinical Trial
Efficacy of ETB-F01 in Patients with Respiratory Symptoms Study Overview Respiratory issues are common and can lead to serious health problems. This study focuses on a treatment called ETB-F01, which contains heat-killed Akkermansia muciniphila strain EB-AMDK19. We wanted to see if it helps reduce respiratory symptoms. Trial Details This was a randomized, double-blind trial involving […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEnhancing the Impact of Individualized Nutrition Therapy with Real-Time Continuous Glucose Monitoring Feedback in Overweight and Obese Individuals with Prediabetes
Enhancing Nutrition Therapy with Glucose Monitoring for Prediabetes Background and Objectives Prediabetes increases the risk of serious health issues like type 2 diabetes and heart disease. Early detection and lifestyle education are essential to prevent these complications. This study explored how real-time feedback from continuous glucose monitoring (CGM) can improve individualized nutrition therapy (INT) for […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseCognitive benefits of folic acid supplementation during pregnancy track with epigenetic changes at an imprint regulator
Cognitive Benefits of Folic Acid Supplementation During Pregnancy Study Overview This study explores how folic acid during pregnancy affects cognitive development in children. It focuses on the ZFP57 gene, which plays a key role in gene regulation and is influenced by folate levels. Research Methods We analyzed data from a previous clinical trial called FASSTT, […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffectiveness of intra-oral botulinum toxin injection in comparison to the extra-oral approach on pain and quality of life in patients with myofascial pain: a randomized clinical trial
Effectiveness of Intra-Oral Botulinum Toxin Injection for Myofascial Pain Study Overview This study compares two methods of injecting botulinum toxin for treating myofascial pain in the masseter muscle: intra-oral and extra-oral techniques. Objective The goal was to see which injection method is more effective in reducing pain and improving quality of life for patients with […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEconomic evaluation of an adjunctive intraocular and peri-ocular steroid vitreoretinal surgery for open globe trauma: Cost-effectiveness of the ASCOT randomised controlled trial
Economic Evaluation of ASCOT Trial for Eye Trauma Background In the UK, around 5,000 people suffer eye injuries each year, with 250 resulting in permanent blindness. This study looks at the cost-effectiveness of using an adjunctive steroid treatment during surgery for patients with open globe trauma compared to standard treatment. Methods This evaluation was part […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseNoninvasive early identification of durable clinical benefit from immune checkpoint inhibition: a prospective multicenter study (NCT04566432)
Noninvasive Early Identification of Clinical Benefits from Immune Checkpoint Inhibition Study Overview This study focuses on how to quickly identify patients with non-small cell lung cancer (NSCLC) who benefit from immune checkpoint inhibitors (ICIs). Out of 328 patients screened, 101 were enrolled, and 83 were evaluated for ICI effectiveness. Among these, 56 patients showed durable […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseWearable equipment-based telemedical management via multiparameter monitoring on cardiovascular outcomes in elderly patients with chronic coronary heart disease: an open-labelled, randomised, controlled trial
Wearable Telemedicine for Heart Disease Management in Elderly Patients Background Chronic coronary heart disease (CHD) is common in older adults and is a leading cause of death and health issues. Study Purpose This study explored how effective telemedicine is for managing elderly patients with CHD using remote monitoring. Methods We enrolled 1,248 elderly patients with […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
The effect of vildagliptin versus metformin on hepatic steatosis in type 2 diabetic patients: a randomized controlled trial
The Effect of Vildagliptin vs. Metformin on Liver Fat in Type 2 Diabetes Patients Study Overview This study investigated how two medications, vildagliptin and metformin, affect liver fat in patients recently diagnosed with type 2 diabetes (T2D). We used the Hepatic Steatosis Index (HSI) and ultrasound to measure liver health. Research Details Participants: 246 patients […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phasePhase 2A Proof-of-Concept Double-Blind, Randomized, Placebo-Controlled Trial of Nicotinamide in Early Alzheimer Disease
Phase 2A Trial of Nicotinamide for Early Alzheimer Disease Study Overview This study tested nicotinamide, a coenzyme that may help reduce tau phosphorylation in early Alzheimer Disease (AD). Trial Details Type: Double-blind, randomized, placebo-controlled Duration: 48 weeks Dose: 1,500 mg of nicotinamide, taken twice daily Participants 47 participants were enrolled, aged around 74 years, with […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseFacing depression: evaluating the efficacy of the EmpkinS-EKSpression reappraisal training augmented with facial expressions — protocol of a randomized controlled trial
Facing Depression: A New Approach to Treatment Study Overview: This clinical trial aims to improve depression treatment by evaluating a new training method that combines cognitive restructuring with facial expression techniques. The focus is on how our thoughts and physical expressions can impact depression. Background Depression is often linked to negative thinking patterns. Current treatments, […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseUltrasound-guided transbronchial cryobiopsy of mediastinal and hilar lesions: a multicenter pragmatic cohort study with real-world evidence
Ultrasound-Guided Transbronchial Cryobiopsy Study Overview This study evaluates the effectiveness and safety of ultrasound-guided transbronchial cryobiopsy for examining mediastinal and hilar lesions. It compares this method to the standard technique known as EBUS-TBNA. Study Details Patients in four Swiss centers who needed diagnostic bronchoscopy for specific lesions were included. The study focuses on: Diagnostic yield […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseCombining fire needle plus cupping with famciclovir and gabapentin in the treatment of acute herpes zoster: a revised intervention approach
Combining Fire Needle and Cupping with Medication for Herpes Zoster Treatment Study Overview This study explored the effectiveness and safety of combining fire needle and cupping therapy with oral medications famciclovir and gabapentin for treating acute herpes zoster (AHZ). It involved 84 patients who were randomly divided into three groups. Groups and Treatments Group A: […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Is Mat pilates effective in lower limb strength and hand grip strength of people with Parkinson’s? A randomized clinical trial with follow-up
Is Mat Pilates Effective for People with Parkinson’s? Study Overview This study investigates whether Mat Pilates can improve lower limb strength and hand grip strength in individuals with Parkinson’s disease. It was conducted over 12 weeks and included 23 participants aged around 62 years. Key Findings Hand Grip Strength: Significant improvement was observed in the […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEnhancing motor function in children with cerebral palsy: A Comparative study of pediatric tuina and conventional rehabilitation
Enhancing Motor Function in Children with Cerebral Palsy Study Overview This study investigates how combining Pediatric Tuina (PT) with traditional rehabilitation affects motor skills in children with cerebral palsy (CP). Methodology In this controlled trial, 115 children aged 1 month to 13 years with CP participated. They were divided into two groups: Experimental Group: 57 […] ➡️➡️➡️