Standard Versus Family-Based Screening, Brief Intervention, and Referral to Treatment for Adolescent Substance Use in Primary Care: Protocol for a Multisite Randomized Effectiveness Trial ABSTRACT Screening, brief intervention, and referral to treatment for adolescents (SBIRT-A) is recommended for detecting and intervening in alcohol and other drug (AOD) use in pediatric primary care. This trial aims…
Comparison of Working Alliance in Blended Cognitive Behavioral Therapy and Treatment as Usual for Depression in Europe Practical Solutions and Value Increasing interest has focused on the working alliance in digital mental health interventions. This study aimed to compare the working alliance scores between blended cognitive behavioral therapy (bCBT) and treatment as usual (TAU) for…
Effect of a diabetes-specific formula in non-diabetic inpatients with stroke: a randomized controlled trial Background/Objectives: In patients with acute stroke, high blood sugar levels have been linked to more severe symptoms and limited recovery. This study aimed to assess the impact of a specialized diabetes-specific liquid nutrition on blood sugar levels, other health problems, and…
Static Palpation Precision Evaluation Study Introduction Clinicians often use manual therapy to treat low back pain by feeling the spine to find the spinous processes. This study aims to assess how well experienced clinicians can consistently locate these spinous processes from S1 to T12 through palpation. The results will be compared to topographical data representing…
Mobile Phone-Based Confidential Social Network Referrals for HIV Testing (CONSORT): Protocol for a Randomized Controlled Trial Background Critical to ending the HIV epidemic is finding undiagnosed individuals and engaging them in care. Using mobile phones in high HIV prevalence areas can help reach social networks for HIV testing and treatment. Objective This study aims to…
Tofacitinib: Effective Treatment for Ulcerative Colitis Highlights of the Study: A pragmatic prospective study assessed tofacitinib’s efficacy for moderate to severe ulcerative colitis (UC). Intestinal ultrasound (IUS) was evaluated as a tool to distinguish responders from non-responders in real-time. Key Findings: • 30 adult patients started tofacitinib; most had left-sided or extensive colitis and had…
Comparison of IASTM and ESWT in Myofascial Pain Syndrome Background/Aim: To compare the effectiveness of instrument-assisted soft tissue mobilization (IASTM) and extracorporeal shock wave therapy (ESWT) in treating myofascial pain syndrome (MPS) and to determine their superiority over conservative treatment (CT). Materials and Methods: 42 female MPS patients were randomly assigned to CT, CT+IASTM, or…
Effects of Mindfulness-Based Cognitive Therapy for Chinese Adults with PTSD Symptoms: Protocol for a Randomised Controlled Trial Abstract Introduction: Mindfulness-based cognitive therapy (MBCT) has shown promise as a potential psychotherapy for post-traumatic stress disorder (PTSD). This trial aims to test the effects of MBCT compared to an active control for individuals with subthreshold PTSD. Method…
Final Analysis: Phase II Trial of Daratumumab, Carfilzomib, Lenalidomide, and Dexamethasone in Newly Diagnosed Multiple Myeloma Key Findings We studied the effectiveness and safety of a 24-cycle treatment combining Daratumumab with carfilzomib, lenalidomide, and dexamethasone in newly diagnosed multiple myeloma patients without needing a stem cell transplant. Our primary goal was to achieve a stringent…
Impact of Intravascular Imaging-Guided Stent Optimization According to Clinical Presentation in Patients Undergoing Complex PCI Practical Solutions and Value Background: The study aimed to determine if intravascular imaging-guided stent optimization has different effects based on the clinical presentation during complex percutaneous coronary intervention (PCI). Methods: Patients with complex coronary artery lesions were randomly assigned to…
The Influence of Diet Therapy and Physical Training on MCP-1 Secretion in Obese Patients with Coronary Heart Disease Key Findings: After a 12-week intervention, participants experienced significant improvements including: 4.0% reduction in body weight 4.2% decrease in waist circumference 5.4% reduction in visceral fat 9.8% decrease in total cholesterol 16.6% decrease in LDL-cholesterol 26% decrease…
Government Direct-to-Consumer Education to Reduce Prescription Opioid Use: A Cluster Randomized Clinical Trial ABSTRACT Importance: Direct-to-consumer education has been effective in reducing chronic sedative use, but its effectiveness for prescription opioids among patients with chronic noncancer pain has not been tested. Objectives: This trial aimed to evaluate the effectiveness of a government-led educational information brochure…
Gastrointestinal symptoms and dietary intake of patients with irritable bowel syndrome following a low FODMAP diet ABSTRACT High FODMAP (fermentable oligo-, di, monosaccharides and polyols) foods have been linked with worsening symptoms of IBS patients. The aim was to compare gastrointestinal symptoms and dietary intake of patients with irritable bowel syndrome following a low FODMAP…
Effects of Athletic Tape on Orofacial Pain and Jaw Movements: Clinical Trial Results Summary Researchers conducted a clinical trial to investigate the effects of athletic tape on orofacial pain and jaw movements in adults with temporomandibular disorder. The study involved 22 participants who were randomly assigned to two groups. Method Participants in Group A had…
Posterior Crossbite Corrections in Early Mixed Dentition: Cost-Effectiveness Analysis Background Unilateral posterior crossbite is a common dental issue in children, and early treatment is recommended for normal growth. The choice of appliances for correcting this condition is important, especially when considering the cost-effectiveness of treatment. Objectives This study aimed to compare the cost-effectiveness of quad…
Efficacy of Esketamine for Prenatal Depression in Mothers Key Results and Practical Considerations Results: A single low dose of esketamine significantly reduced the prevalence of major depressive episodes at 42 days postpartum in mothers with prenatal depression when compared to a placebo. This represents a substantial reduction in postpartum depression risk. Additionally, esketamine led to…
Treatment Outcomes of Pulpotomy vs. Pulpectomy in Vital Primary Molars with Irreversible Pulpitis Background Pulpectomy has been the traditional treatment for vital primary molars with irreversible pulpitis. However, recent advancements suggest that pulpotomy, a more conservative approach, could be effective. This trial aims to compare the effectiveness of pulpotomy versus pulpectomy in managing symptomatic irreversible…
Study Title A study on the effectiveness of low-dose olanzapine in preventing nausea and vomiting during chemotherapy Objective To evaluate the effectiveness of 5 mg olanzapine in preventing chemotherapy-induced nausea and vomiting (CINV) in female patients with gastrointestinal tract tumors undergoing moderately emetogenic chemotherapy (MEC). Methods Patients received either 5 mg olanzapine with palonosetron and…
GLORIA Trial: Combining CXCL12 Inhibition and Radiotherapy in Glioblastoma Key Findings: The GLORIA trial combined radiotherapy with the CXCL12-neutralizing aptamer olaptesed pegol (NOX-A12) in patients with newly-diagnosed glioblastoma. The study found that the treatment was safe and well-tolerated, with no dose-limiting toxicities or treatment-related deaths. Increasing the NOX-A12 dose levels led to higher NOX-A12 plasma…
ASSIST Trial: Impact of Strength Exercise Volume on Insulin Sensitivity in Obese Adults Overview The ASSIST trial aims to investigate the effects of high- and low-volume strength exercise sessions on insulin sensitivity in obese adults, providing valuable insights for personalized exercise prescription. Background Type 2 diabetes mellitus is characterized by impaired insulin action, and acute…