Study Title: A gut microbiota rheostat forecasts responsiveness to PD-L1 and VEGF blockade in mesothelioma Nature Communications, August 21, 2024 Key Findings: Malignant mesothelioma, a rare cancer linked to asbestos exposure, has limited treatment options and poor prognosis. A multi-center phase II clinical trial (MiST4, NCT03654833) evaluated atezolizumab and bevacizumab (AtzBev) in relapsed mesothelioma patients,…
HSD3B1 Genotype and Outcomes in Metastatic Prostate Cancer Practical Solutions and Value Highlights HSD3B1 genotype plays a role in metastatic hormone-sensitive prostate cancer (mHSPC) outcomes. The AP allele is linked to castration resistance, particularly in low-volume tumors, affecting post-progression mortality and treatment-emergent adverse events. Enzalutamide plus androgen deprivation therapy (ADT) in men with mHSPC showed…
Effect of Narrative Photography on Physical Therapy Students’ Learning Outcomes in Heart Transplantation Nursing and Health Sciences, September 2024, Volume 26, Issue 3, Article e13155 Physical therapy students need to understand how to care for patients undergoing heart transplantation, including their emotional and practical needs. This study compared the effectiveness of a narrative photography (NP)…
Comparison of Two Symptom Checkers (Ada and Symptoma) in the Emergency Department: Randomized, Crossover, Head-to-Head, Double-Blinded Study ABSTRACT Emergency departments (EDs) are often overcrowded, and nonurgent patients frequently seek care there. Symptom checkers (SCs) provide immediate access to disease suggestions and recommended actions, potentially improving patient flow. However, there is a lack of evidence supporting…
Evaluating the Efficacy of a Digital Therapeutic (CT-152) as an Adjunct to Antidepressant Treatment in Adults With Major Depressive Disorder: Protocol for the MIRAI Remote Study ABSTRACT Major depressive disorder (MDD) is a common and highly disabling condition. Many individuals with MDD do not experience full symptom relief with current treatments, so new options are…
Study Highlights Speech-related temporal parameters (SRTPs) may be sensitive indicators of the efficacy of acetylcholinesterase (AChE) inhibitor therapy in mild Alzheimer’s disease. Automatic speech recognition in the Speech-Gap Test® revealed improvements in filled pause duration ratio, count ratio, and frequency after 12 and 24 weeks of donepezil treatment. ADAS-Cog total scores showed slight improvement, with…
Efficacy of a Mobile App-Based Intervention for Young Adults With Anxiety Disorders: A Randomized Clinical Trial ABSTRACT Young adults often face undertreatment for anxiety disorders. Maya, a mobile cognitive behavioral therapy (CBT) intervention, was tested in a randomized clinical trial. The study aimed to assess the efficacy and engagement with the intervention, comparing the effects…
Efficacy and Feasibility of Combined Treatment for Neurodermatitis Objective To assess the effectiveness and practicality of using compound fluocinolone acetonide cream and guaiazulene in treating neurodermatitis. Methods A study was conducted on 92 neurodermatitis patients, dividing them into control and experimental groups. The control group received compound fluocinolone acetonide cream, while the experimental group also…
Multivitamin Compliance Reduces Injuries of Female Recruits at Air Force Basic Training: A Randomized Controlled Cohort Study ABSTRACT Introduction: Basic military training (BMT) for U.S. Air Force and Space Force recruits is critical, but musculoskeletal injuries (MSKI) can threaten success. Trainees with nutritional deficiencies are at higher risk, so efforts to mitigate issues include providing…
Effect of Early Administration of Tetracosactide on Mortality and Host Response in Critically Ill Patients Requiring Rescue Surgery Summary Early administration of tetracosactide (TCS10) in critically ill patients undergoing rescue surgery significantly reduced 30-day mortality and improved hemostatic disorders. The drug targeted melanocortin receptors (MCRs) and showed promising results in a phase 3 randomized controlled…
Ultrasound Radiomics for Forecasting Adverse Cardiovascular Events Objective Assessing the effectiveness of ultrasound-based radiomics in predicting major adverse cardiovascular events (MACE) within 1 year after percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS) patients. Methods 161 ACS patients who underwent PCI were included, with 114 in the training set and 47 in the validation…
Serum β2-Microglobulin Predicts Time to Recovery of Delayed Graft Function in Kidney Transplant Recipients Background Delayed graft function (DGF) after kidney transplantation can lead to negative patient and allograft outcomes. Prolonged DGF is linked to worse graft outcomes. The relationship between posttransplant serum β2-microglobulin (B2M) and DGF recovery is not well understood. Methods All kidney-only…
Effect of Messaging on Support for Breast Cancer Screening Cessation Among Older US Women: A Randomized Clinical Trial Abstract Many older women are screened for breast cancer beyond recommended guidelines. This study aimed to investigate the impact of a message on older women’s support for and intentions of stopping breast cancer screening. Intervention A pilot-tested…
Vital parameter monitoring in harsh environment by the MedSENS in-ear multisensor device ABSTRACT Accurate assessment of vital parameters is crucial for diagnosing and prioritizing critically ill patients, especially in out-of-hospital settings where suitable devices may be lacking. We conducted a pilot study to extensively validate a novel in-ear device designed for non-invasive measurement of core…
Adverse Event Assessment in Parenting Program: Multisite Trial Results Key Findings Clinical trial results from the RISE project revealed that adverse event (AE) assessment in parenting programs significantly improved over three phases of study, with 100% response rate achieved in the final phase. During the intervention, no serious adverse events (SAE) were registered, and the…
Multiplex real-time PCR in non-invasive respiratory samples to reduce antibiotic use in community-acquired pneumonia: a randomised trial Abstract We evaluated whether using multiplex real-time PCR in addition to standard microbiological testing is safer and more effective than standard testing alone in reducing antibiotic use for community-acquired pneumonia (CAP). In this randomised trial, adults hospitalized with…
Nutritional Support in Hospitalised Patients with Diabetes and Risk for Malnutrition Secondary Analysis of an Investigator-Initiated, Swiss, Randomised Controlled Multicentre Trial Objective: Investigating the effects of nutritional support on mortality in hospitalised patients with diabetes and nutritional risk. Design: Secondary analysis of a Swiss-wide multicentre, randomised controlled trial. Participants: Patients with diabetes and risk for…
Sweat Lactate Sensor for Detecting Anaerobic Threshold in Heart Failure: LacS-001 Clinical Trial Abstract A prospective clinical trial (LacS-001) aimed to investigate the safety and correlation between sweat lactate threshold (sLT) and ventilatory threshold (VT) in patients with heart failure (HF). 50 HF patients participated in incremental exercise tests while using a sweat lactate-monitoring sensor.…
Nontargeted Metabolomic Profiling Analysis of Corn Silk Treatment for Type 2 Diabetes Mellitus Medicine (Baltimore). 2024 Aug 16;103(33):e39396 Patients with newly diagnosed type 2 diabetes mellitus (T2DM) were studied to understand the effects of corn silk treatment. The study found that patients receiving corn silk experienced a significant decrease in glycosylated hemoglobin and fasting blood…
Pelvic Floor Muscle Training in Women with Urinary Incontinence and Pelvic Organ Prolapse: A Protocol Study Objective To assess the impact of pelvic floor muscle training (PFMT) on pelvic floor muscle (PFM) function and quality of life (QoL) in women with stress urinary incontinence (SUI) and pelvic organ prolapse (POP). Methods This study will involve…