Tetracycline Three Times Daily Versus Four Times Daily in Bismuth-Containing Quadruple Therapy as the First-Line Treatment of Helicobacter pylori Infection: A Multicenter, Noninferiority, Randomized Controlled Trial ABSTRACT Current guidelines recommend bismuth-containing quadruple therapy for patients newly diagnosed with Helicobacter pylori (H. pylori) infection. This study aimed to compare the efficacy and safety of tetracycline administered…
Efficacy Comparison of Osteopathic Muscle Energy Techniques and Cervical Mobilization on Pain, Disability, and Proprioception in Cervical Spondylosis Patients Key Findings: Cervical spondylosis (CS) causes persistent neck pain and decreased mobility. This study compared the effectiveness of osteopathic muscle energy technique (MET) and cervical mobilization (CM) on 76 CS patients. Practical Solutions: Both MET and…
Relationship between NT-proBNP, Echocardiographic Abnormalities and Functional Status in Patients with Subclinical Diabetic Cardiomyopathy Introduction Diabetes can lead to heart muscle disease (cardiomyopathy) through different mechanisms. The connection between natriuretic peptides, heart structure issues, and functional abilities in diabetic cardiomyopathy (DbCM) patients is not well understood. Methods In this study, 685 patients with asymptomatic DbCM…
Implementation of Integrated Care for Type 2 Diabetes Mellitus and Periodontitis in Germany: Study Protocol for a Practice-based and Cluster-randomized Trial Background Type 2 Diabetes mellitus (T2DM) and periodontitis have common risk factors and can impact each other. However, primary care and oral health care are currently separate and do not coordinate care for patients…
Early Anti-Coagulation Therapy in New-Onset Atrial Fibrillation after Coronary Artery Bypass Grafting: A Randomized Trial Pilot Study Background New-onset postoperative atrial fibrillation (POAF) is a common complication after coronary artery bypass grafting (CABG) surgery, increasing the risk of embolism and stroke. This study aimed to compare the feasibility and safety of Warfarin and Rivaroxaban in…
Patient-Representing Population’s Perceptions of GPT-Generated Versus Standard Emergency Department Discharge Instructions: Randomized Blind Survey Assessment ABSTRACT Discharge instructions from the emergency department (ED) to home are crucial for patient communication but often get overlooked. Generative artificial intelligence and large language models (LLMs) offer a solution to create high-quality and personalized discharge instructions. This study aimed…
Role of Bacillus coagulans (Heyndrickxia coagulans)BCP92 in managing irritable bowel syndrome: A randomized, double-blind, multicenter, placebo-controlled clinical trial ABSTRACT Irritable bowel syndrome (IBS) is a significant global healthcare burden, and effective intervention is crucial. This study investigated the effectiveness and safety of Bacillus coagulans BCP92, a probiotic, in managing IBS symptoms. METHODS A randomized controlled…
Tildrakizumab Real-World Effectiveness and Safety Over 64 Weeks in Patients With Moderate-to-Severe Plaque Psoriasis Background Tildrakizumab, a treatment for moderate-to-severe plaque psoriasis, was evaluated for its real-world effectiveness and safety over 64 weeks. Methods Adults with moderate-to-severe plaque psoriasis received tildrakizumab 100 mg at specified intervals. Effectiveness was measured using body surface area affected, Physician…
Exploring the Impact of Home-Based Exercise Adherence on Low Back Pain Recovery Key Findings Adherence to home-based exercise (HBE) recommendations is crucial in physiotherapy for low back pain (LBP) patients. This study investigated the relationship between adherence to HBE and changes in physical function, pain intensity, and recovery from LBP. Practical Solutions Adherence to HBE…
Radiofrequency Ablation for Bile Duct Cancer (ACTICCA-2 Trial) Key Findings and Practical Solutions The ACTICCA-2 trial assessed the impact of adding radiofrequency ablation (RFA) to biliary stenting in patients with unresectable bile duct cancer undergoing palliative systemic therapy. Patients were randomized to receive either RFA plus bile duct stenting or bile duct stenting alone, with…
Impact of a Community Pharmacy-Based Medication Therapy Management Program on Clinical and Humanistic Outcomes in Patients with Uncontrolled Diabetes: A Randomised Controlled Trial Abstract This study aimed to assess the impact of a community pharmacy (CP)-based medication therapy management (MTM) program on the health and satisfaction of patients with uncontrolled diabetes. Patients were randomly assigned…
Vonoprazan-amoxicillin Dual Therapy for Helicobacter Pylori Eradication in Chinese Population Study Overview This study aimed to assess the effectiveness of Vonoprazan-amoxicillin dual therapy (VAT) for treating Helicobacter pylori (H. pylori) in the Chinese population. Key Findings The study found that VAT administered for 10 or 14 days achieved a higher eradication rate of H. pylori…
Study on High-Fidelity Simulation for Medical Student Skills Enhancement Published in Med J Malaysia, July 2024 Introduction: This study compared the effectiveness of high-fidelity simulation (HFS) versus video-assisted lecture (VAL) in enhancing and retaining skills among undergraduate medical students. HFS provides realistic hands-on experience in a safe environment, while VAL involves interactive video-based teaching. Materials…
Effect of Nano-Curcumin Supplementation on Cardiometabolic Risk Factors and Quality of Life Key Findings from Clinical Trial Researchers conducted a randomized double-blind clinical trial to investigate the effects of a highly bioavailable curcumin supplement on patients with coronary slow flow phenomenon (CSFP). The study involved 42 patients, aged 35-70 years, with body mass index between…
Diagnosis to Ablation in Persistent AF: Any Time Can Be a Good Time to Ablate Key Findings: Results from the CAPLA trial show that patients with shorter Diagnosis-to-Ablation Time (DAT) had lower rates of atrial fibrillation (AF) recurrence after ablation. Practical Solutions: Using standardized entry criteria and intensive monitoring, clinicians can identify the optimal timing…
Educational Intervention on Perceived Stress in Adults with Type 2 Diabetes and Metabolic Syndrome Key Findings from the Clinical Trial During the six-month non-randomized clinical trial, a nurse-led educational health-promoting program was conducted with 51 adults diagnosed with type 2 diabetes mellitus and metabolic syndrome. The intervention resulted in a significant decrease in perceived stress…
Reducing Alcohol Consumption in Alcohol Dependent Individuals: A Pilot Feasibility Study Summary A trial was conducted to check the potential of transdermal alcohol sensors (TASs) in reducing alcohol consumption in individuals undergoing treatment for alcohol use disorder (AUD). The study aimed to assess the feasibility of using TASs and contingency management (CM) for alcohol monitoring…
Efficacy and Mechanism of Acupoint Catgut Embedding in the Treatment of Chronic Spontaneous Urticaria: Protocol for a Randomized Double-Blind Placebo-Controlled Trial Background Chronic spontaneous urticaria (CSU) is a common skin disease causing itching and wheals, significantly impacting quality of life. Acupuncture has shown promise in treating CSU, but its short duration of action and frequent…
Effectiveness and Acceptability of Targeted Text Message Reminders in Colorectal Cancer Screening: M-TICS Study Background Mobile phone-based SMS text message reminders have the potential to improve colorectal cancer screening participation rates. Objective This study aimed to assess the effectiveness and acceptability of adding targeted SMS text message reminders to the standard procedure for individuals who…
Benefits of Upgrading Right Ventricular to Biventricular Pacing in Heart Failure Patients with Atrial Fibrillation Abstract Recommendations for cardiac resynchronization therapy (CRT) in patients with atrial fibrillation are not as well-established as those for patients with sinus rhythm. The BUDAPEST-CRT Upgrade trial aimed to assess the effectiveness of CRT upgrade in heart failure patients with…