Effects of Intensive Mask-Wearing on Postinfectious Cough Study Overview This study investigates the impact of wearing face masks for extended periods on patients suffering from postinfectious cough, a common issue that affects patients and adds financial strain. Traditional medication has not been very effective for this condition. Study Methodology A total of 46 patients with…
Healthy Lifestyle Care vs Guideline-Based Care for Low Back Pain Study Overview This study compares a Healthy Lifestyle Program (HeLP) with standard care for managing low back pain. Why It Matters Living an unhealthy lifestyle may worsen low back pain, but it’s unclear if addressing these lifestyle issues improves patient results. Study Goals The goal…
Effects of Wearable Activity Trackers on Joint Function and Quality of Life in Osteoarthritis Background Osteoarthritis (OA) causes pain and limits daily activities. Physical activity (PA) is essential for treatment. Wearable activity trackers (WATs) can help people monitor their activity levels and encourage sustainable exercise. Study Overview This study analyzed the impact of self-monitoring PA…
Healing Potential of Blood Clot, S-PRF, and A-PRF in Treating Non-Vital Teeth Overview This study explored how effective different regenerative treatments are for treating necrotic mature teeth with chronic periapical periodontitis over 18 months. Study Details We included 51 adult participants with single-rooted teeth affected by chronic periapical periodontitis. They were divided into three groups…
Study Overview: FEDORA Trial Background Myelofibrosis (MF) is a serious blood disease with a median survival of only 6.5 years. The common gene mutation in these patients is JAK2V617F, which causes continuous activation of certain proteins. Fedratinib is a JAK2 inhibitor that is taken orally and has shown promise in treating MF. However, combining it…
Safety and Effectiveness of Dual Therapy for H. pylori Infection in Diabetes Study Overview This study focuses on patients with type 2 diabetes who are at a higher risk of failing H. pylori treatment. We evaluated the safety and effectiveness of a dual therapy using vonoprazan and amoxicillin (VA) for treating H. pylori infection in…
Neoadjuvant or Concurrent Atezolizumab with Chemoradiation for Locally Advanced Cervical Cancer Study Overview This study focused on the use of atezolizumab (an immune checkpoint blocker) alongside chemoradiation for patients with locally advanced cervical cancer (LACC). The trial aimed to determine the best way to combine these treatments. Key Findings Study Design: Patients were divided into…
Effectiveness of Shared Decision Making Strategies for Stroke Prevention Study Overview This study assessed how well different decision-making aids help patients with non-valvular atrial fibrillation (AF) in preventing strokes. Study Details Design: A cluster randomized controlled trial. Location: Six academic medical centers in the United States. Participants: 1117 patients aged 18 and older, diagnosed with…
Effectiveness of an 8-Week Neck Exercise Program for Women with TMD Study Overview This study tested an 8-week neck exercise program to see how it affects pain, jaw function, and oral health-related quality of life (OHRQoL) in women with Temporomandibular Disorders (TMD). The trial involved 54 women aged 18-45 diagnosed with myofascial or mixed TMD.…
Effects of White Noise Intervention on Sleep Quality and Immunological Indicators in Breast Cancer Patients Objective The study aimed to assess how white noise affects sleep quality and immune responses in breast cancer patients undergoing neoadjuvant chemotherapy (NAC). Methods From January 2020 to December 2022, 104 newly diagnosed female breast cancer patients were randomly assigned…
Evaluating Time-Restricted Eating in Women with PCOS Background Time-restricted eating (TRE) is a method that helps manage weight. However, the best eating window is still debated. This study focuses on the safety and effectiveness of TRE for overweight and obese women with polycystic ovary syndrome (PCOS). Objective The goal of this study is to examine…
Self- versus Clinician-Collected Swabs in Anal Cancer Screening: A Clinical Trial Background Anal cancer risk is high in certain groups, and screening requires anal swabs for HPV DNA and cytology tests. However, many people face challenges like the need for intimate exams and stigma related to HIV status, sexual orientation, and practices. Self-collected anal swabs…
Sudden Gains in Treating Prolonged Grief in Children and Adolescents Objective Sudden gains refer to significant and lasting improvements in symptoms that occur between two treatment sessions. This study looks at sudden gains in children and adolescents with Prolonged Grief Disorder (PGD), a condition recognized in recent mental health classifications. The goal was to explore…
Mediators of a Randomized Controlled Trial for Youth with Depressed Parents Objective This study looked at how a specific family therapy program helps children of parents with major depression or dysthymia. We wanted to understand how this program affects children’s long-term mental health symptoms and diagnoses. Method The research involved 180 parents (average age 41.9,…
Biomarkers in Down Syndrome and Alzheimer’s Disease Background People with Down Syndrome (DS) have a genetic type of Alzheimer’s disease (AD). In our study, we used plasma samples from a previous clinical trial that tested Vitamin E as an anti-inflammatory treatment for DS. Although the trial focused on cognitive improvements, Vitamin E did not show…
Biomarkers Study Overview The study published in Alzheimers Dement. 2024 focuses on the effects of AGB101, a medication that aims to normalize brain activity in patients with mild cognitive impairment (MCI) related to Alzheimer’s disease (AD). The HOPE4MCI clinical trial lasted 78 weeks and evaluated the impact of AGB101 on patients who are ApoE-4 non-carriers.…
Public Health Overview Study Title: Early Dementia Diagnosis in Cuba Reference: Alzheimers Dement. 2024 Dec;20 Suppl 7:e086012. doi: 10.1002/alz.086012 Background A large number of the 57 million people with dementia live in low- and middle-income countries, where research on dementia is limited. Our goal was to improve early diagnosis and the use of standard cognitive…
Public Health Study Overview This study analyzed the cost-effectiveness of the Japanese multimodal intervention trial for dementia prevention (J-MINT) from a societal viewpoint. Methodology We used a Markov model to assess the economic impact of the J-MINT trial, which included participants aged 65 to 85 with mild cognitive impairment. Participants were divided into two groups:…
Public Health Overview Background Research shows that sex and gender influence Alzheimer’s and Dementia differently. Women are often diagnosed later than men, which poses challenges for healthcare and clinical trials due to potential gender biases in participant selection. About the CITA GO-ON Trial The CITA GO-ON study (ClinicalTrials.gov, NCT04840030) is a randomized clinical trial designed…
Public Health Study Overview This study looks at the healthcare needs of people living with dementia (PlwD), especially those with Alzheimer’s disease. Many needs are not being met, and we aim to understand the factors that influence these unmet needs to create better support systems. Methodology We analyzed data from a multi-centre clinical trial called…