Study Highlights: 2.6% Benzoyl Peroxide AV Cleanser for Sensitive Skin Effective and Well-Tolerated Treatment for Acne Vulgaris A clinical study evaluated the efficacy and safety of a 2.6% Benzoyl Peroxide (BPO) cleanser designed for sensitive skin in treating mild-to-moderate acne vulgaris (AV). The results showed a significant reduction in AV lesions as early as one…
Evaluation of Dentoalveolar Changes in Gummy Smile Subjects Comparison of One vs Two Anterior Miniscrews for Maxillary Incisor Intrusion Objective: To assess dentoalveolar changes after maxillary incisor intrusion with one or two anterior miniscrews in subjects with gummy smile and deep bite. Materials and Methods: Forty-three subjects were divided into two groups: group I with…
A Randomized Controlled Trial to Determine the Impact of Resistance Training versus Aerobic Training on the Management of FGF-21 and Related Physiological Variables in Obese Men with Type 2 Diabetes Mellitus Key Findings: Fibroblast growth factor 21 (FGF-21) is a potential therapeutic target for insulin resistance in type 2 diabetes. This study compared the effects…
Time-restricted eating and low-carbohydrate diet improve heart and thyroid health in metabolic syndrome Summary Researchers found that time-restricted eating (TRE) and low-carbohydrate diet (LCD) can significantly improve heart and thyroid function in people with metabolic syndrome (MetS). The study involved 169 MetS patients, who were randomly assigned to the LCD group, the 8-hour TRE group,…
Effects of Fructan and Gluten on Gut Microbiota in Non-Celiac Gluten/Wheat Sensitivity Practical Solutions and Value Highlights Individuals with non-celiac gluten/wheat sensitivity (NCGWS) often experience improvement in gastrointestinal symptoms with a gluten-free diet. This study aimed to investigate the effects of fructo-oligosaccharides (FOS) and gluten on gut microbiota and related factors in NCGWS patients. The…
Feasibility and Benefits of Telemedicine in Emergency Care Introduction Telemedicine involves remote patient care using new information and communication technologies. This study evaluates the remote management of patients in emergency services during pre-pandemic and pandemic periods of COVID-19. Methods A prospective, randomized, controlled study was conducted at FarhatHached Hospital in Sousse. The telemedicine group received…
Study Highlights The study compared a newly developed portable oxygen concentrator with an auto-demand oxygen delivery system (auto-DODS) to a continuous flow oxygen concentrator for Home Oxygen Therapy patients with nocturnal hypoxemic symptoms. Primary Endpoint: The auto-DODS did not reduce oxygen saturation (SpO2) by at least 2.8% on average compared to continuous flow. Safety: No…
Sintilimab Combined with Immunochemotherapy in Primary CNS Lymphoma: Phase 2 Study Key Findings: – Sintilimab combined with high-dose methotrexate, temozolomide, and rituximab showed a 96.3% overall response rate in newly diagnosed primary central nervous system lymphoma (PCNSL) patients. – The treatment regimen demonstrated high efficacy and tolerability, with 25 complete responses out of 27 evaluable…
Low Dose Tamoxifen and Lifestyle Changes for Breast Cancer Prevention (TOLERANT Study) Study Overview The TOLERANT study aims to evaluate the impact of different interventions, including low-dose tamoxifen (LDT), intermittent caloric restriction (ICR), lifestyle intervention (LI), and their combinations on biomarkers associated with breast cancer risk in high-risk women. Study Design Unaffected women aged 18-70…
Assessment of Photodynamic Therapy for Halitosis Treatment in Children Published in PLoS One, September 2024 Objective: The study aimed to evaluate the effectiveness of antimicrobial photodynamic therapy (aPDT) using annatto-based dye combined with blue LED for treating halitosis in mouth-breathing children. Materials and Methods: 52 children aged six to twelve with mouth breathing and halitosis…
MRI Predicts Residual Disease and Outcomes in Watch-and-Wait Patients with Rectal Cancer Radiology. 2024 Sep;312(3):e232748. doi: 10.1148/radiol.232748. Background: MRI plays a crucial role in restaging locally advanced rectal cancer treated with total neoadjuvant therapy (TNT). However, its ability to accurately select patients for nonoperative management has not been fully evaluated in prospective studies. Purpose: To…
Increased Risk of Kidney Failure in Patients with Genetic Kidney Disorders Practical Solutions and Value Highlights Recent study published in J Clin Invest revealed that patients with genetic kidney disorders are at higher risk of kidney failure. The study assessed three patient cohorts and found that monogenic kidney disorders and high-risk APOL1 genotypes were associated…
Lessons from the EQUAL Trial: Tailoring Weight Loss Interventions for Cancer Survivors Key Takeaways: Despite challenges, the EQUAL trial sheds light on the need for tailored, remotely delivered weight loss interventions for cancer survivors, particularly those with acute lymphoblastic leukemia (ALL). Key differences in study populations and intervention contexts contributed to the trial’s null results,…
Effect of Blue Light Emitting Diode Therapy on Recurrent Vulvovaginal Candidiasis: A Randomized Assessor-Blinded Controlled Trial Objective Vulvovaginal Candidiasis (VVC) is a common genital infection in women and requires effective non-drug therapies. This study aimed to investigate the effect of blue light emitting diode (LED) therapy as an alternative treatment for recurrent VVC due to…
Efficacy and Safety of Methotrexate Plus Hydroxychloroquine Combination Therapy vs. Methotrexate Monotherapy in the Treatment of Rheumatoid Arthritis: A Randomized Controlled Clinical Trial Key Findings: Combining methotrexate (MTX) with hydroxychloroquine (HCQ) showed a more significant reduction in pain, disease activity, and inflammatory factors compared to MTX monotherapy. The quality of life was also higher in…
Exploring the Effect of Exercise versus Metformin on Insulin Resistance amongst Nigerians with Pre-diabetes: A Randomised Controlled Trial ABSTRACT Pre-diabetes is a significant risk factor for type 2 diabetes in Nigeria. This study aimed to compare the impact of moderate exercise and metformin interventions on insulin resistance among participants with pre-diabetes. Using a randomised placebo-controlled…
Reduced-dose chemotherapy and blinatumomab as induction treatment for newly diagnosed Ph-negative B-cell precursor acute lymphoblastic leukemia: a phase 2 trial Abstract Blinatumomab has shown promise in improving the initial treatment of acute B-cell precursor lymphoblastic leukemia (BCP-ALL). To reduce side effects and improve effectiveness, we conducted a phase 2 trial using reduced-dose chemotherapy (RDC) followed…
Effect of Endothelin-1 on Blood Pressure Response to Hypoxia and Hyperoxia in Young Men Physiological Reports, 2024 Sep;12(17):e70004 Endothelin-1 (ET-1) and its receptors have been linked to increased sensitivity to hypoxic stress and the development of hypertension. This study aimed to investigate the effect of ET receptor antagonism on blood pressure (BP) response to chemoreflex…
Effect of Intranasal Insulin on Perioperative Cognitive Function in Older Adults Key Findings: Administering intranasal insulin to older surgical patients showed significant improvement in postoperative cognitive function, reduced incidence of postoperative delirium, and inhibited certain inflammatory markers. Practical Solutions: Using intranasal insulin could be a potential therapy to enhance postoperative cognition in older surgical patients.…
Assessment of MMP Levels and Clinical Success in Pulpitis and Pulpotomy Treatment Background Matrix metalloproteinases (MMPs) are crucial enzymes in dental pulp tissue function. However, their role in primary teeth remains limited. Further studies are needed to understand their contributions to pulpal defense in primary teeth. Additionally, the effectiveness of Biodentine in treating primary teeth…