Diagnosis to Ablation in Persistent AF: Any Time Can Be a Good Time to Ablate Key Findings: Results from the CAPLA trial show that patients with shorter Diagnosis-to-Ablation Time (DAT) had lower rates of atrial fibrillation (AF) recurrence after ablation. Practical Solutions: Using standardized entry criteria and intensive monitoring, clinicians can identify the optimal timing…
Educational Intervention on Perceived Stress in Adults with Type 2 Diabetes and Metabolic Syndrome Key Findings from the Clinical Trial During the six-month non-randomized clinical trial, a nurse-led educational health-promoting program was conducted with 51 adults diagnosed with type 2 diabetes mellitus and metabolic syndrome. The intervention resulted in a significant decrease in perceived stress…
Reducing Alcohol Consumption in Alcohol Dependent Individuals: A Pilot Feasibility Study Summary A trial was conducted to check the potential of transdermal alcohol sensors (TASs) in reducing alcohol consumption in individuals undergoing treatment for alcohol use disorder (AUD). The study aimed to assess the feasibility of using TASs and contingency management (CM) for alcohol monitoring…
Efficacy and Mechanism of Acupoint Catgut Embedding in the Treatment of Chronic Spontaneous Urticaria: Protocol for a Randomized Double-Blind Placebo-Controlled Trial Background Chronic spontaneous urticaria (CSU) is a common skin disease causing itching and wheals, significantly impacting quality of life. Acupuncture has shown promise in treating CSU, but its short duration of action and frequent…
Effectiveness and Acceptability of Targeted Text Message Reminders in Colorectal Cancer Screening: M-TICS Study Background Mobile phone-based SMS text message reminders have the potential to improve colorectal cancer screening participation rates. Objective This study aimed to assess the effectiveness and acceptability of adding targeted SMS text message reminders to the standard procedure for individuals who…
Benefits of Upgrading Right Ventricular to Biventricular Pacing in Heart Failure Patients with Atrial Fibrillation Abstract Recommendations for cardiac resynchronization therapy (CRT) in patients with atrial fibrillation are not as well-established as those for patients with sinus rhythm. The BUDAPEST-CRT Upgrade trial aimed to assess the effectiveness of CRT upgrade in heart failure patients with…
Clinical Trial Results: Closed Loop Stimulation in Patients with Sinus Node Dysfunctions Practical Solutions and Value Closed loop stimulation (CLS) integrated into the circulatory control system through intra-cardiac impedance monitoring reduces the occurrence of atrial high-rate episodes (AHREs) compared with conventional rate-adaptive pacing in patients with sinus node dysfunctions (SNDs). Patients with SNDs and an…
Efficacy and Safety of Hexaspline Pulsed Field Ablation for Atrial Fibrillation Results from the PLEASE-AF Study Background: Pulsed field ablation (PFA) is a promising non-thermal treatment for atrial fibrillation (AF), but its effects on Asian/Chinese populations are not well understood. Study Objective: To assess the 12-month efficacy and safety of a multi-electrode hexaspline PFA catheter…
The effect of education of self-care behaviors on the quality of life and resilience of multiple sclerosis patients Practical Solutions and Value Highlights: Clinical trials play a crucial role in developing safe and effective treatments for patients. Our AI-driven platform, DocSym, consolidates ICD-11 standards, clinical protocols, and research into an easily accessible knowledge base for…
Evaluation of Diode Laser Therapy for Peri-Implantitis Objective To assess the effectiveness of diode laser therapy as an adjunct to non-surgical mechanical therapy in managing peri-implantitis. Methods A cohort of 27 participants with peri-implantitis diagnosis received either diode laser therapy or non-laser treatment. Clinical parameters and peri-implant crevicular fluid (PICF) samples were evaluated at baseline,…
Mobile App Promoting Resilience in Stress Management for Adolescents and Young Adults With Cancer: Protocol for a Pilot Randomized Controlled Trial ABSTRACT Adolescents and young adults (AYAs) with cancer often face significant psychosocial challenges. This pilot randomized controlled trial (RCT) aimed to assess the feasibility, acceptability, and preliminary efficacy of a mobile app version of…
A Transtheoretical Model-Based Online Intervention for Medication Adherence in Chinese Adults with Type 2 Diabetes J Prim Care Community Health. 2024 Jan-Dec;15:21501319241263657 Background: Type 2 diabetes is on the rise in China, with medication non-adherence contributing to uncontrolled diabetes. This study aimed to use the Transtheoretical Model (TTM) in an online intervention to improve medication…
Impact of the COVID-19 Pandemic on CLEAR Outcomes Trial Key Findings: The CLEAR Outcomes Trial investigated the impact of bempedoic acid (BA) versus placebo in 13,970 patients with statin intolerance and high cardiovascular risk. BA reduced the risk of the primary endpoint (composite of CV death, nonfatal myocardial infarction, nonfatal stroke, or coronary revascularization) by…
Feasibility and accuracy of mobile QT interval monitoring strategies in bedaquiline-enhanced prophylactic leprosy treatment Highlights – Evaluation of alternative strategies for QT interval monitoring in settings where electrocardiographic monitoring is challenging – Use of mobile electrocardiogram (mECG) device and automated measurements in phase II randomized controlled BE-PEOPLE trial – 97% of recorded mECGs were of…
Identifying Oxytocin-Sensitive Autism Subtype Study Highlights and Practical Solutions Recent research has revealed that autism subtypes may respond differently to oxytocin treatment, with one subtype showing a significantly higher response rate (61.5%) compared to the other (13.3%). These findings suggest the potential for individualized oxytocin interventions to better target responsive subgroups. The study also identified…
Obesity Impact on Dyspnea in COPD Patients Background The study aimed to assess the impact of obesity on dyspnea in chronic obstructive pulmonary disease (COPD) patients and investigate the relationship between obesity and dyspnea severity in COPD. Methods 127 COPD patients with a BMI ≥ 18.5 kg/m² were included. Dyspnea was assessed using the mMRC…
Comparison between Reirradiation by Stereotactic Body Radiation Therapy and Moderately Hypofractionated Radiotherapy in Combination with Temozolomide for Treatment of Recurrent High Grade Glioma Objective: High grade glioma (HGG) often recurs and lacks a standard treatment. This study compared the effectiveness and side effects of two re-irradiation methods. Methods: Forty patients with recurrent HGG were divided…
Effect of Prostate Cancer Education on Saudi Men: Knowledge, Beliefs, and Screening Intentions Asian Pac J Cancer Prev. 2024 Jul 1;25(7):2439-2444. doi: 10.31557/APJCP.2024.25.7.2439. Abstract Purpose: This study aimed to assess the impact of a prostate cancer educational program on the knowledge, beliefs, and screening intentions of Saudi men. Methods: The study used a quasi-experimental design…
Mechanisms of Neurodynamic Treatments (MONET): Investigating Treatment for Carpal Tunnel Syndrome Study Overview The MONET study aims to understand how neurodynamic exercise interventions affect nerve structure and function in individuals with carpal tunnel syndrome (CTS). Study Design The study includes 78 CTS patients and 30 healthy participants. Patients are randomly assigned to a home-based exercise…
Impact of Combined Prebiotic Galacto-Oligosaccharides and Bifidobacterium breve-Derived Postbiotic on Gut Microbiota and HbA1c in Prediabetic Adults: A Double-Blind, Randomized, Placebo-Controlled Study ABSTRACT The study examined the effects of a 12-week dietary fiber supplement on gut health and metabolic function in prediabetic adults. The supplement contained konjac glucomannan (KGM), galacto-oligosaccharides (GOSs), and exopolysaccharides (EPSs) from…