Optimizing Outcomes in Psychotherapy for Anxiety Disorders Using Smartphone-Based and Passive Sensing Features: Protocol for a Randomized Controlled Trial

Optimizing Outcomes in Psychotherapy for Anxiety Disorders Using Smartphone-Based and Passive Sensing Features: Protocol for a Randomized Controlled Trial

Background

Psychotherapies like cognitive behavioral therapy (CBT) are effective for anxiety disorders, but not everyone benefits from them. This study aims to use digital assessments and passive sensing features to better identify patients who would benefit from CBT.

Objective

This study aims to establish predictive features that forecast responses to transdiagnostic CBT in anxiety disorders and to investigate key mechanisms underlying treatment responses.

Methods

The study is a 2-armed randomized controlled clinical trial including patients with anxiety disorders. Key features are indexed using various assessments and smartphone-based passive sensing to predict treatment responses. Machine learning models will be used to forecast treatment response, and specific mechanistic hypotheses will be tested to understand treatment response mechanisms.

Results

The trial is now completed and the results will be disseminated through publications in scientific peer-reviewed journals and conference presentations.

Conclusions

The aim of this trial is to improve current CBT treatment by precise forecasting of treatment response and by understanding and potentially augmenting underpinning mechanisms and personalizing treatment.

TRIAL REGISTRATION: ClinicalTrials.gov NCT03945617; ClinicalTrials.gov

INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/42547

PMID: 38743473 | DOI: 10.2196/42547

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