Dr M. Trenton
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseCOMPARISON OF EFFICACY OF NSAIDS WITH INTRA- ARTICULAR INJECTION OF CORTICOSTEROIDS IN PATIENTS OF TEMPOROMANDIBULAR DISORDER WITH INTERNAL DISC DISPLACEMENT WITHOUT REDUCTION
Comparison of NSAIDs and Corticosteroids for Temporomandibular Disorder Study Overview This study investigates the effectiveness of NSAIDs versus corticosteroid injections for treating Temporomandibular Disorder (TMD) caused by disc displacement without reduction. TMD can affect the joint and surrounding muscles, and its prevalence varies widely. The trial was conducted at Faisalabad Medical University in Pakistan over […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseLarge language models improve clinical decision making of medical students through patient simulation and structured feedback: a randomized controlled trial
Large Language Models Enhance Medical Students’ Clinical Decision-Making Study Overview This study examines how Large Language Models (LLMs) can improve medical students’ clinical decision-making (CDM) through patient simulations and feedback. Key Findings We developed AI prompts that simulate patients with various symptoms for realistic medical conversations. In our trial: The control group had simulated conversations […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseAllocation and validation of the second revision of the International Staging System in the ICARIA-MM and IKEMA studies
New Insights from the Second Revision of the International Staging System Overview of the Study The International Staging System for multiple myeloma has been updated to include new factors that affect patient prognosis. This update, called R2-ISS, enhances our understanding of multiple myeloma by considering additional high-risk features. Study Findings In the ICARIA-MM and IKEMA […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseCost-effectiveness of C-reactive protein point of care testing for safely reducing antibiotic consumption for acute exacerbations of chronic obstructive pulmonary disease as part of the multicentre, parallel-arm, open, individually randomised, controlled PACE trial
Cost-Effectiveness of C-Reactive Protein Testing for Antibiotic Use in COPD Study Overview This study evaluated the use of C-reactive protein point-of-care testing (CRP-POCT) to help reduce unnecessary antibiotic prescriptions in patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD). Excessive antibiotic use can lead to waste, antibiotic resistance, and potential harm to patients. Research […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseInternet-Delivered Psychoeducation (SCOPE) for Transition-Aged Autistic Youth: Pragmatic Randomized Controlled Trial
Internet-Delivered Psychoeducation (SCOPE) for Transition-Aged Autistic Youth Study Overview The SCOPE program is an 8-week online psychoeducation intervention designed for autistic youth. This study tested its effectiveness through a randomized controlled trial. Goals of the Study The main goal was to see if SCOPE could help participants better understand autism and improve their quality of […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseImpact of a Dynamic Orthosis on Manual Dexterity Among People With Parkinson’s Disease: A Randomized Trial
Impact of a Dynamic Orthosis on Manual Dexterity in Parkinson’s Disease Importance of the Study A dynamic elastomeric fabric orthosis may offer a new non-drug treatment for motor symptoms in people with Parkinson’s disease (PD). Study Objective The goal was to assess how effective the orthosis is in improving manual dexterity in individuals with PD. […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseTransverse versus longitudinal skin incision in first extensor tendon release for radial styloid tenosynovitis: a randomized controlled trial
Transverse vs. Longitudinal Skin Incision in Surgery for De Quervain’s Tenosynovitis Study Overview De Quervain’s tenosynovitis causes pain and swelling near the wrist. When non-surgical treatments fail, surgery is often needed. This study compared two surgical techniques: transverse and longitudinal skin incisions, focusing on scars, pain, and recovery. Methodology Seventy patients were randomly assigned to […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseHow much should the resting heart rate be controlled in patients with atrial fibrillation and coronary heart disease?
Controlling Resting Heart Rate in Patients with Atrial Fibrillation and Coronary Heart Disease Study Overview Current guidelines suggest keeping the resting heart rate below 100-110 beats per minute (bpm) for patients with atrial fibrillation (AF). However, there is little research on treating patients with both atrial fibrillation and coronary heart disease (AF&CHD). Key Findings We […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseUtilization of Motor Imagery Training for Improvement of Balance of Ataxic Children after Medulloblastoma Resection
Using Motor Imagery Training to Help Balance in Ataxic Children after Tumor Surgery Study Overview This study looked at how motor imagery training can improve balance and walking in children who had surgery for medulloblastoma. Fifty children, ages seven to nine, with cerebellar ataxia were selected from the Tumor Hospital of Cairo University for this […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Abbreviated or Standard Antiplatelet Therapy After PCI in Diabetic Patients at High Bleeding Risk
Abbreviated or Standard Antiplatelet Therapy After PCI in Diabetic Patients at High Bleeding Risk Study Overview This study examines the effects of abbreviated antiplatelet therapy (APT) compared to standard APT in patients with high bleeding risk (HBR) who have diabetes mellitus (DM). The goal is to find out if a shorter treatment duration can reduce […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Avatar Intervention in Virtual Reality for Cannabis Use Disorder in Individuals With Severe Mental Disorders: Results From a 1-Year, Single-Arm Clinical Trial
Avatar Intervention in Virtual Reality for Cannabis Use Disorder Study Overview This study explored a new way to treat cannabis use disorder (CUD) in individuals with severe mental disorders (SMD) using virtual reality (VR). The goal was to see if this method could help reduce cannabis use and improve overall well-being over a year. Why […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffect of community health education on mothers’ knowledge of obstetric danger signs and birth preparedness and complication readiness practices in southern Ethiopia: A cluster randomized controlled trial
Effect of Community Health Education on Mothers in Southern Ethiopia Introduction Increasing mothers’ understanding of obstetric danger signs (ODS) and promoting birth preparedness and complication readiness (BPCR) are vital for improving maternal health services in low-income countries. Health education interventions (HEI) led by women’s groups could be an effective way to achieve this. However, there […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
A Blended Learning Course on the Diagnostics of Mental Disorders: Multicenter Cluster Randomized Noninferiority Trial
A Blended Learning Course on the Diagnostics of Mental Disorders Overview This study focused on improving how mental disorders are diagnosed through a blended learning course. Accurate diagnoses are crucial for effective patient treatment, and poor diagnoses can lead to serious issues. Study Goals The aim was to develop and assess a blended learning course […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseMinimal changes in sleep parameters during overnight ambulatory blood pressure monitoring do not affect outcomes
Minimal Changes in Sleep During Overnight Blood Pressure Monitoring Study Overview This study investigated how overnight ambulatory blood pressure monitoring (ABPM) affects sleep. While ABPM is the best method for checking blood pressure, it might disrupt sleep. Previous research showed mixed results, and this study is unique because it used polysomnography, a more precise sleep […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Population pharmacokinetic analysis of quizartinib in patients with newly diagnosed FLT3-internal-tandem-duplication-positive acute myeloid leukemia
Population Pharmacokinetic Analysis of Quizartinib in AML Patients Study Overview This study focuses on the pharmacokinetics (PK) of quizartinib and its active metabolite, AC886, in patients with newly diagnosed FLT3-internal-tandem-duplication-positive acute myeloid leukemia (AML). The analysis used data from the Phase 3 QuANTUM-First trial and 12 earlier studies. Key Findings Three-Compartment Model: Quizartinib PK was […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseDirect and Gradual Electrical Testicular Shocks Stimulate Spermatogenesis and Activate Sperms in Infertile Men: A Randomized Controlled Trial
Direct and Gradual Electrical Testicular Shocks Improve Sperm Production in Infertile Men Study Overview About 15% of couples face infertility, with male factors contributing to nearly half of the cases. This often results from issues like low sperm production and sperm dysfunction. In this study, 90 infertile men with various sperm issues participated in a […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseTransbronchial Needle Aspiration via Ultrathin Bronchoscope Improves Diagnostic Yield for Peripheral Lung Lesions: Randomized Sequencing Trial
Transbronchial Needle Aspiration via Ultrathin Bronchoscope Improves Diagnostic Yield for Peripheral Lung Lesions Study Overview This study investigates how combining ultrathin bronchoscopy with peripheral transbronchial needle aspiration (pTBNA) can enhance the diagnosis of peripheral pulmonary lesions (PPLs). Key Findings Improved Diagnostic Yield: The overall diagnostic yield was 66.3%, with pTBNA contributing an additional 11.9% of […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
The Effects of Omega-3 Fatty Acids and Vitamin D Supplementation on the Nutritional Status of Women with Breast Cancer in Palestine: An Open-Label Randomized Controlled Trial
The Effects of Omega-3 Fatty Acids and Vitamin D Supplementation on Women with Breast Cancer in Palestine Study Overview This study highlights the importance of early nutrition for women newly diagnosed with breast cancer. It focused on how omega-3 fatty acids and vitamin D3 supplementation can improve their nutritional status. Methodology A total of 88 […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffect of Postbiotic Bifidobacterium longum CECT 7347 on Gastrointestinal Symptoms, Serum Biochemistry, and Intestinal Microbiota in Healthy Adults: A Randomised, Parallel, Double-Blind, Placebo-Controlled Pilot Study
Effect of Postbiotic Bifidobacterium longum CECT 7347 on Digestive Health Study Overview This study evaluated the impact of heat-treated Bifidobacterium longum CECT 7347 (HT-ES1) on digestive symptoms in healthy adults. It was a randomised, double-blind, placebo-controlled trial with 60 participants over 8 weeks, followed by a check-in at week 10. Key Methods Researchers measured: Gastrointestinal […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Assessing Changes in Motor Function and Mobility in Individuals with Parkinson’s Disease After 12 Sessions of Patient-Specific Adaptive Dynamic Cycling
Assessing Changes in Motor Function and Mobility in Individuals with Parkinson’s Disease Study Overview This study looked at how 12 sessions of patient-specific adaptive dynamic cycling (PSADC) compared to non-adaptive cycling (NA) affected motor function and mobility in people with Parkinson’s disease (PD). We used advanced sensors to measure changes accurately. Methodology Twenty-three participants with […] ➡️➡️➡️