Dr M. Trenton
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEfficacy of a Structured Yoga Intervention Integrated with Routine Care versus Exercise on Pulmonary Function and Quality of Life of Asthma Patients: A Randomized Controlled Trial
Efficacy of Yoga Intervention for Asthma Patients Results of a Randomized Controlled Trial A study was conducted to evaluate the effectiveness of a structured yoga intervention integrated with routine care for asthma patients in improving their pulmonary function and quality of life. The study involved adults aged 18 to 60 with mild to moderate asthma. […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseTwo doses of fosaprepitant included prophylactic treatment for the three-day cisplatin-based chemotherapy induced nausea and vomiting
Study on Fosaprepitant for Chemotherapy-Induced Nausea and Vomiting Practical Solutions and Value: Two doses of fosaprepitant were studied for preventing nausea and vomiting caused by three-day cisplatin-based chemotherapy in lung cancer patients. This study aimed to explore the effectiveness and safety of using two doses of fosaprepitant for this purpose. The study involved 204 participants […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseFunctional changes in sleep-related arousal after ketamine administration in individuals with treatment-resistant depression
Functional Changes in Sleep-Related Arousal After Ketamine Administration Study Details The study examined the effects of ketamine on sleep and mood in individuals with treatment-resistant depression. Research Objectives The aim was to compare sleep metrics between individuals with treatment-resistant major depression (TRD) and healthy volunteers, and to assess whether ketamine normalizes arousal in TRD. Additionally, […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffects of the «AI-TA» Mobile App With Intelligent Design on Psychological and Related Symptoms of Young Survivors of Breast Cancer: Randomized Controlled Trial
Effects of the “AI-TA” Mobile App on Psychological Symptoms of Young Breast Cancer Survivors Background Young breast cancer survivors often experience psychological challenges, impacting their quality of life. Mobile apps have shown potential as interventions, but their effectiveness varies. There is a lack of evidence on the impact of intelligent app features on addressing psychological […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseService Dogs for Veterans and Military Members With Posttraumatic Stress Disorder: A Nonrandomized Controlled Trial
Service Dogs for Veterans and Military Members With Posttraumatic Stress Disorder: A Nonrandomized Controlled Trial Key Findings: Military members and veterans with posttraumatic stress disorder (PTSD) may benefit from partnering with trained psychiatric service dogs. This study aimed to assess the impact of this intervention on PTSD symptom severity, depression, anxiety, and psychosocial functioning among […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseThe need for and acceptability of a cancer training course for medical and nursing students in Tanzania: a convergent mixed methods study
Study Title: The need for and acceptability of a cancer training course for medical and nursing students in Tanzania: a convergent mixed methods study Background The burden of cancer in Africa is increasing, and it is crucial to provide healthcare providers with proper training in cancer screening, prevention, care, and community education. This training can […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseHospital policy of tranexamic acid to reduce transfusion in major non-cardiac surgery (TRACTION): protocol for a phase IV randomised controlled trial
Hospital Policy of Tranexamic Acid to Reduce Transfusion in Major Non-cardiac Surgery (TRACTION): Protocol for a Phase IV Randomised Controlled Trial Abstract Tranexamic acid (TXA) is a widely available and affordable medication that reduces blood loss and red blood cell (RBC) transfusion in cardiac and orthopaedic surgeries. This trial aims to evaluate whether implementing a […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseResults of a randomized double-blind multicenter clinical trial of the efficacy and safety of riamilovir in the treatment of COVID-19
Results of a Clinical Trial on Riamilovir for COVID-19 Treatment Published in Ter Arkh, June 2024 AIM: To assess the effectiveness and safety of riamilovir in treating COVID-19 in adults. MATERIALS AND METHODS: The study involved 180 adult patients with confirmed COVID-19 who met specific criteria and provided informed consent. RESULTS: The clinical trial confirmed […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phasePooled analysis of NeoCARH and NeoCART trials: patient-reported outcomes in patients with early-stage breast cancer receiving platinum-based or anthracycline-based neoadjuvant chemotherapy
Pooled Analysis of NeoCARH and NeoCART Trials: Patient-Reported Outcomes in Early-Stage Breast Cancer Background Neoadjuvant chemotherapy is a standard treatment for early-stage breast cancer (EBC) that is triple-negative or human epidermal growth factor receptor 2 positive (HER2 +). However, there is limited data comparing the impact of anthracycline-based and platinum-based regimens on patients’ health-related quality […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffectiveness of topical hyaluronic acid of different molecular weights in xerosis cutis treatment in elderly: a double-blind, randomized controlled trial
Effectiveness of Topical Hyaluronic Acid in Treating Dry Skin in the Elderly Study Overview Dry skin is a common issue in the elderly, often due to reduced hyaluronic acid (HA) levels. This study aimed to compare the effectiveness of low and high molecular weight HA in moisturizers for treating dry skin in aging individuals. Key […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
One spinal manipulation session reduces local pain sensitivity but does not affect postural stability in individuals with chronic low back pain: a randomised, placebo-controlled trial
One Spinal Manipulation Session for Chronic Low Back Pain Key Findings: – Spinal manipulation reduces lumbar pain sensitivity in chronic low back pain patients. – It does not affect postural stability compared to a sham session. – Both the actual and simulated manipulation led to clinically significant decreases in self-reported pain intensity. – A higher […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffectiveness of couple education and counseling on uptake of cervical cancer screening among women in Southern Ethiopia: a cluster randomized trial
Effectiveness of Couple Education and Counseling on Cervical Cancer Screening Uptake Key Findings Cervical cancer is a significant global health issue, particularly in developing countries, due to low screening rates and late-stage detection. This study aimed to assess the impact of couple education and counseling on women’s uptake of cervical cancer screening. The intervention involved […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffect of adding diaphragmatic breathing to corrective exercises on kyphotic angle and diaphragmatic excursion in postmenopausal kyphotic women: A randomized controlled trial
Effect of Adding Diaphragmatic Breathing to Corrective Exercises for Postmenopausal Women with Kyphosis: Clinical Trial Results Overview Age-related thoracic kyphosis can impact posture, diaphragmatic function, and quality of life for postmenopausal women. Methods 40 postmenopausal women with thoracic kyphosis were split into two groups. Group A received corrective exercises for 12 weeks, while Group B […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
EFFECT OF LOW-LEVEL DIODE LASER ON DENTIN TOPOGRAPHY AND SYMPTOMATIC NONCARIOUS CERVICAL LESIONS PRIOR TO COMPOSITE RESTORATIONS: A SPLIT-MOUTH RANDOMIZED CONTROLLED TRIAL
EFFECT OF LOW-LEVEL DIODE LASER ON DENTIN TOPOGRAPHY AND SYMPTOMATIC NONCARIOUS CERVICAL LESIONS PRIOR TO COMPOSITE RESTORATIONS: A SPLIT-MOUTH RANDOMIZED CONTROLLED TRIAL Summary: This study examined the impact of low-level diode lasers on reducing sensitivity in symptomatic noncarious cervical lesions (NCCLs) before composite restoration. It focused on changes in dentin topography using a scanning electron […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseCost-effectiveness of enoxaparin versus aspirin in the prevention of venous thromboembolism after total hip or knee arthroplasty: an analysis from the CRISTAL cluster-randomized trial
COST-EFFECTIVENESS OF ENOXAPARIN VERSUS ASPIRIN IN PREVENTING VENOUS THROMBOEMBOLISM Key Findings from the CRISTAL Trial The CRISTAL trial compared the costs and benefits of using enoxaparin versus aspirin to prevent symptomatic venous thromboembolism (VTE) after total hip or knee arthroplasty. The study found that: Enoxaparin was more effective in preventing symptomatic VTE within 90 days […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseCost-effectiveness analysis of soft bandage and immediate discharge versus rigid immobilization in children with distal radius torus fractures
Cost-effectiveness analysis of soft bandage and immediate discharge versus rigid immobilization in children with distal radius torus fractures Summary The study compared the cost-effectiveness of using a soft bandage and immediate discharge versus rigid immobilization in children aged four to 15 years with a torus fracture of the distal radius. The research aimed to evaluate […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseProspective multicentre accuracy evaluation of the FUJIFILM SILVAMP TB LAM test for the diagnosis of tuberculosis in people living with HIV demonstrates lot-to-lot variability
Prospective Multicentre Evaluation of FUJIFILM SILVAMP TB LAM Test Key Findings A clinical trial evaluated the diagnostic accuracy of the urine-based lipoarabinomannan assay FUJIFILM SILVAMP TB LAM (FujiLAM) for tuberculosis in people living with HIV across seven high-burden countries. Overall, the FujiLAM demonstrated a sensitivity of 54.4% and specificity of 85.2% against the extended mycobacterial […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseSibling-Support for Adolescent Girls (SSAGE): A study protocol for a pilot randomized-controlled trial of a whole-family, gender transformative approach to preventing mental illness among forcibly displaced adolescent girls
Study Title: Sibling-Support for Adolescent Girls (SSAGE) Objective: Preventing Mental Illness among Forcibly Displaced Adolescent Girls Forcibly displaced adolescent girls are at higher risk for mental illness, especially due to gender inequity. The study aims to assess the effectiveness of a whole-family, gender transformative intervention called Sibling Support for Adolescent Girls in Emergencies (SSAGE) in […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Impact of Skills for Change Program on metabolic control, diet and physical activity levels in adults with type 2 diabetes: A cluster randomized trial
Impact of Skills for Change Program on Type 2 Diabetes Management Summary A 12-month trial was conducted in the United Arab Emirates to assess the impact of a culturally adapted lifestyle intervention on adults with type 2 diabetes. The intervention focused on diet and physical activity levels, guided by the social cognitive theory. Key Findings […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Incidence of self-reported tuberculosis treatment with community-wide universal testing and treatment for HIV and tuberculosis screening in Zambia and South Africa: A planned analysis of the HPTN 071 (PopART) cluster-randomised trial
Study Title: Incidence of self-reported tuberculosis treatment with community-wide universal testing and treatment for HIV and tuberculosis screening in Zambia and South Africa: A planned analysis of the HPTN 071 (PopART) cluster-randomised trial Key Findings: In a study involving over 1 million individuals, community-wide universal testing and treatment for HIV (UTT) combined with tuberculosis (TB) […] ➡️➡️➡️