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Number of Retrieval Attempts and the Association of Intravenous Tirofiban with Symptomatic Intracranial Hemorrhage in Patients with Successful Endovascular Therapy: Results of the RESCUE BT Trial

Study Overview

This study examines how intravenous tirofiban and the number of retrieval attempts relate to symptomatic intracranial hemorrhage (sICH) in patients undergoing endovascular therapy (EVT).

Key Findings

  • Participants: 866 patients were analyzed.
  • Tirofiban Use: Patients receiving tirofiban had a higher risk of sICH (OR: 1.853).
  • Retrieval Attempts: More than 2 retrieval attempts significantly increased the risk of sICH (3 attempts vs. 0-1: OR: 2.482).
  • Interaction Effect: The risk of sICH was notably higher in patients with multiple retrieval attempts when tirofiban was used (OR: 5.534).

Conclusion

In patients with multiple retrieval attempts, using intravenous tirofiban may raise the risk of sICH. More research is needed to tailor the use of tirofiban in EVT based on individual patient needs and procedural details.

Clinical Implications

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