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Study Title:
Blood Interleukin-18 (IL-18) and IL-18 Binding Protein (IL-18BP) Levels Following Midline Laparotomy: A Prospective Randomized Study of Patients With Benign Disease and Patients With Cancer
Abstract:
Background/Aim: The study aimed to investigate the acute phase immune response (APR) in patients undergoing midline laparotomy (MLa) and its association with blood IL-18 and IL-18BP levels and the numeric rating scale (NRS) pain score.
Patients and Methods: Blood levels of seven cytokines and high-sensitivity C-reactive protein (hs-CRP) were measured at three time points in 56 patients with MLa. Patient satisfaction at 24 hours post-MLa was recorded on an 11-point numeric rating scale.
Results: IL-18 and IL-18BP blood levels decreased immediately after operation (POP1) and then increased significantly at 24 hours after operation (POP2). Patients with cancer had higher IL-18 values compared to those with benign disease. IL-18BP levels correlated with patient satisfaction at 24 hours post-MLa.
Conclusion: The study suggests that the acute phase immune response and quality of life are associated in MLa patients, highlighting the potential value of monitoring IL-18BP levels in post-operative care.
PMID: 38677734 | DOI: 10.21873/anticanres.17007
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