Clinical trials

Rationale and design of a double-blinded, randomized placebo-controlled trial of 40 Hz light neurostimulation therapy for depression (FELIX) ABSTRACT BACKGROUND: Major depressive disorder (MDD) affects over 300 million people globally, and current treatments rely on trial-and-error. Reliable biomarkers are needed for more informed and personalized treatment solutions. Gamma-frequency brainwaves (30-80 Hz) are potential biomarkers linked […] ➡️➡️➡️

Heat-sensitive moxibustion combined with tropisetron hydrochloride for chemotherapy-induced nausea and vomiting: a randomized controlled trial Objective To compare the effectiveness of heat-sensitive moxibustion combined with tropisetron hydrochloride versus tropisetron hydrochloride alone in treating chemotherapy-induced nausea and vomiting (CINV). Methods Sixty CINV patients were randomly divided into two groups. The control group received tropisetron hydrochloride, while […] ➡️➡️➡️

Effectiveness of Movement System Impairment Model in Treating Neck Pain: Clinical Trial Results Background Movement System Impairment (MSI) classification and treatment effectively diagnose and treat individuals with neck pain. Current guidelines lack movement-specific mechanical diagnosis for neck pain management. Purpose This study aimed to investigate the effectiveness of the movement system impairment model among neck […] ➡️➡️➡️

Feasibility study of a novel digital template-guided flapless extraction for maxillary palatal impacted teeth Objective With the advancement of 3D printing technology, this study aimed to explore a minimally invasive approach for extracting deeply impacted maxillary palatal teeth using a novel digital guide template and flapless technique. Methods 40 patients with palatal impacted teeth were […] ➡️➡️➡️

CLINICAL TRIAL RESULTS A randomized controlled trial to compare the effects of time-restricted eating versus Mediterranean diet on symptoms and quality of life in bipolar disorder Background: This study aimed to compare the effectiveness of time-restricted eating (TRE) with the Mediterranean diet for individuals with bipolar disorder (BD) experiencing sleep or circadian rhythm disturbances. Methods: […] ➡️➡️➡️

Quantitative Analysis of Essential Oil Mouthrinses on Plaque Microbiome BMC Oral Health. 2024 May 18;24(1):578. doi: 10.1186/s12903-024-04365-9. Background: The oral cavity’s microorganisms greatly impact oral health. This study introduces a new method to measure the effects of essential oil mouthrinses on dental plaque microbiome using DNA standards and metagenome sequencing. Methods: In a randomized trial, […] ➡️➡️➡️

Study Title The influence of mindfulness meditation combined with progressive muscle relaxation training on the clinical efficacy and quality of life of patients with sarcopenia receiving haemodialysis: a randomised controlled trial Key Findings The study found that combining mindfulness meditation with progressive muscle relaxation training significantly improved exercise capacity and kidney disease quality of life […] ➡️➡️➡️

Safety and Efficacy of Inebilizumab for Neuromyelitis Optica Spectrum Disorder End-of-Study Results from N-MOmentum Trial In a recent study published in Lancet Neurology, the safety and efficacy of inebilizumab for treating neuromyelitis optica spectrum disorder were investigated. The study included both the randomised controlled period and the open-label extension period. Key Findings 225 participants received […] ➡️➡️➡️

Feasibility and Acceptability of Tailored Health Coaching for Type 2 Diabetes Management in Saudi Arabia Key Findings The study aimed to assess the feasibility and acceptability of tailored health coaching to improve type 2 diabetes self-management in Saudi Arabia. The research involved a 12-week randomised controlled trial with 30 Saudi adults diagnosed with type 2 […] ➡️➡️➡️

Effects of Maitland Mobilization Technique on Upper Extremity Function in Stroke Survivors with Spasticity Study Overview The study aimed to explore the impact of Maitland joint mobilization technique on the recovery of upper extremity function in stroke patients with spasticity. Methods 71 patients with upper extremity flexor spasm after stroke were enrolled and randomly assigned […] ➡️➡️➡️

Key Findings from Clinical Trial Overview In diabetic macular edema (DME), hyper-reflective foci (HRF) are found in almost all patients and are linked to disease severity and progression. The study used automated analysis to examine the distribution of HRF in relation to intraretinal fluid (IRF). Practical Solutions and Value The study’s findings provide valuable insights […] ➡️➡️➡️

The Impact of Back Optic Zone Design in Orthokeratology on Visual Performance Transl Vis Sci Technol. 2024 May 1;13(5):12. doi: 10.1167/tvst.13.5.12. ABSTRACT PURPOSE: This study aimed to assess the visual performance in adolescents undergoing orthokeratology treatment with different optical zone diameters (OZDs). METHODS: The study was conducted at Tianjin Eye Hospital in June 2022, enrolling […] ➡️➡️➡️

Exploratory Biomarker Analysis in Olaparib Maintenance Therapy for Ovarian Cancer Study Overview The L-MOCA trial has shown that olaparib maintenance therapy is effective and safe for Chinese patients with platinum-sensitive relapsed ovarian cancer. This study explores the impact of homologous recombination deficiency (HRD) and programmed cell death ligand 1 (PD-L1) expression on olaparib’s effectiveness. Biomarker […] ➡️➡️➡️

Comparison of Three Diagnostic Strategies for Pulmonary Embolism Key Research Findings Pulmonary embolism (PE) is a challenging condition to diagnose and can be life-threatening when missed. This study aims to compare the effectiveness of three diagnostic strategies: planar ventilation-perfusion scan (V/Q), CT pulmonary angiography (CTPA), and single photon emission CT ventilation-perfusion scan (SPECT V/Q) in […] ➡️➡️➡️

Remote Live Stream Assessment Validity in Duchenne Muscular Dystrophy Patients Key Findings: Remote functional assessment scores strongly correlate with in-person scores. Remote assessments have the potential to reduce the burden on families by supplementing in-clinic visits. Practical Solutions and Value: Using remote live stream video evaluation for functional assessments in patients with Duchenne muscular dystrophy […] ➡️➡️➡️

Effectiveness of a Web-Based Cognitive Behavioral Self-Help Intervention for Binge Eating Disorder: A Randomized Clinical Trial Abstract Importance: Binge eating disorder (BED) causes significant emotional and physical distress, but access to specialized treatment is limited. Web-based self-help interventions offer a more accessible solution. Objective: To assess the effectiveness of a web-based cognitive behavioral self-help intervention […] ➡️➡️➡️

Pharmacogenomics, Race, and Treatment Outcome in Pediatric Acute Myeloid Leukemia ABSTRACT IMPORTANCE: Disparities in outcomes exist between Black and White patients with acute myeloid leukemia (AML), with Black patients experiencing poorer prognosis compared with their White counterparts. OBJECTIVE: To assess whether varying intensity of induction therapy to treat pediatric AML is associated with reduced disparities […] ➡️➡️➡️

Study Title: Intraoperative intravenous versus periarticular injection of glucocorticoids in improving clinical outcomes after total knee arthroplasty: A prospective, randomized and controlled study Abstract: Background: Glucocorticoids are commonly used for pain relief after total knee arthroplasty (TKA), but the best way to administer them is still debated. This study compares the effectiveness of glucocorticoids given […] ➡️➡️➡️

Effects of a respiratory and neurological rehabilitation treatment plan in post Covid-19 affected university students Practical Solutions and Value Highlights COVID-19 can lead to respiratory and neurological complications such as loss of sense of smell and taste. This study aimed to evaluate the effectiveness of a pulmonary and neurological rehabilitation program in post-SARS-CoV-2 patients. Study […] ➡️➡️➡️

Evaluating the Efficacy of an Oral Probiotic in Acne Vulgaris Study Details The study aimed to assess the effectiveness of an oral probiotic in treating acne vulgaris in patients aged 12 to 30 years. The probiotic used was a capsule containing Lacticaseibacillus rhamnosus (CECT 30031) and the cyanobacterium Arthrospira platensis (BEA_IDA_0074B). Key Findings Patients taking […] ➡️➡️➡️