Clinical trials

“`html A Randomized, Double-Blind, Placebo-Controlled Pilot Trial of the Acute Antisuicidal and Antidepressant Effects of Intranasal (R,S)-Ketamine in Severe Unipolar and Bipolar Depression With and Without Comorbid Alcohol Use Disorder ABSTRACT Objective: This study aimed to investigate the effects of intranasal (IN) racemic (R,S)-ketamine on antisuicidal and antidepressant outcomes in patients with unipolar and bipolar […] ➡️➡️➡️

“`html Efficacy and Safety of Choline Alfoscerate in Preventing Dementia in Elderly Patients Key Findings: Over a three-year period, a study involving 100 patients with mild cognitive impairment (aMCI) showed that annual therapy with choline alfoscerate (CA) had a significant preventive effect on the progression to clinically pronounced dementia. Patients receiving CA therapy experienced a […] ➡️➡️➡️

“`html ARTISAN RCT: Advice vs. Advice and Physiotherapy for Shoulder Dislocation Key Findings The study compared the effectiveness of advice alone versus advice with a physiotherapy program for first-time traumatic shoulder dislocation. The results showed little difference in the primary outcome or secondary outcomes between the two groups. However, the addition of physiotherapy was likely […] ➡️➡️➡️

“`html Reducing Time to Differentiated Service Delivery for Newly-Diagnosed People Living with HIV in Kigali, Rwanda: Pilot Trial Results Key Highlights: Examined feasibility, acceptability, and preliminary impact of entry into differentiated service delivery (DSD) at six months after ART initiation for newly-diagnosed PWH. Randomized controlled trial conducted in three health facilities in Rwanda. High patient-level […] ➡️➡️➡️

“`html Sildenafil Versus Placebo for Early Pulmonary Vascular Disease in Scleroderma (SEPVADIS): Protocol for a Randomized Controlled Trial Background Pulmonary hypertension (PH) is a leading cause of death in patients with systemic sclerosis (SSc). Early detection and treatment of PH is crucial for SSc patient management. The SEPVADIS trial aims to investigate the potential benefits […] ➡️➡️➡️

“`html Prednisone Use and Diabetes Risk in Rheumatoid Arthritis Patients Study Overview A 10-year subanalysis of the BeSt study examined the association between prednisone use, disease activity score (DAS), and the development of hyperglycaemia and diabetes in early rheumatoid arthritis (RA) patients. Key Findings Out of 504 non-diabetic early RA patients, 6.2% developed diabetes during […] ➡️➡️➡️

“`html Motor Effects of Intervention With Transcranial Direct Current Stimulation for Physiotherapy Treatment in Children With Cerebral Palsy: Protocol for a Randomized Clinical Trial ABSTRACT Children with cerebral palsy often face challenges in movement and daily activities. This study aims to assess the additional effects of combining physiotherapy with transcranial direct current stimulation (tDCS) in […] ➡️➡️➡️

“`html Microbiological Effects of Adjunctive Treatment in Non-Surgical Periodontal Care Study Overview Researchers investigated the microbiological effects of using a gel containing sodium hypochlorite and amino acids in addition to subgingival debridement (SD) compared to SD alone in patients with stages II-III periodontitis. Key Findings After 6 months, the group receiving the adjunctive treatment showed […] ➡️➡️➡️

“`html Cost-Effectiveness of Temperature Monitoring to Prevent Foot Ulcer Recurrence in Diabetes Diabetes-related foot ulcers are a common and costly issue. We conducted a trial to assess the cost-effectiveness of at-home skin temperature monitoring in preventing diabetes-related foot ulcer recurrence. Key Findings The intervention group had significantly lower foot care costs and fewer participants with […] ➡️➡️➡️

“`html Recipient Biomarkers Predicting Metabolic Improvements After Fecal Microbiota Transplantation Key Highlights Fecal microbiota transplantation (FMT) combined with dietary fiber supplements improved glucose regulation in adults with severe obesity and metabolic syndrome. Recipients’ baseline fecal microbiota composition could predict improvements in insulin resistance after FMT. Responders to FMT therapy showed higher engraftment rates of donor-specific […] ➡️➡️➡️

“`html Study Title: Comprehensive Analysis of Neoadjuvant Camrelizumab and Chemotherapy for Locally Advanced Gastric Cancer Background The study aimed to evaluate the effectiveness of combining neoadjuvant camrelizumab with chemotherapy in treating locally advanced gastric cancer. This approach is being explored as a potential alternative to the current standard treatment. Methods The study involved a single-arm, […] ➡️➡️➡️

“`html Evaluation and Comparison of a New Desensitizing Paste Study Overview A clinical trial studied the effects of a new paste containing 8% L-Arginine and CaCO3 plus KNO3 on dentinal tubules occlusion and dental sensitivity. Methods 24 dentin surfaces were divided into two groups, one receiving the experimental paste and the other a placebo. Permeability […] ➡️➡️➡️

“`html Cost-effectiveness of Methenamine Hippurate vs. Antibiotic Prophylaxis for Recurrent Urinary Tract Infections Key Findings: Results from a multicentre trial showed that methenamine hippurate was on average less costly and more effective than antibiotic prophylaxis for managing recurrent urinary tract infections in women. Practical Solutions: Using methenamine hippurate could lead to cost savings and improved […] ➡️➡️➡️

“`html Effect of Vitamin D and Letrozole on Ovulation in Polycystic Ovary Syndrome Published: BMJ Open, April 29, 2024 Low vitamin D levels are common in women with polycystic ovary syndrome (PCOS). This study aims to evaluate the impact of vitamin D supplementation on ovulation rates with letrozole and other reproductive, endocrine, and metabolic outcomes […] ➡️➡️➡️

“`html Visual Performance of Optical Films Utilizing Spatio-Temporal Optical Phase Technology SIGNIFICANCE: Spatio-Temporal Optical Phase technology uses film pairs with optical elements on single-vision spectacle lenses. It has the potential to reduce myopia progression, but its visual performance is unclear. PURPOSE: This study aimed to evaluate the visual performance of film pairs containing optical elements […] ➡️➡️➡️

“`html Randomized Placebo-Controlled Clinical Trial of Dutasteride for Reducing Heavy Drinking in Men ABSTRACT Prior studies suggest that dutasteride, a medication used for benign prostatic hypertrophy, may help reduce heavy drinking in men by affecting certain brain chemicals. This study aimed to test the effectiveness and safety of dutasteride for this purpose. METHODS 142 men […] ➡️➡️➡️

“`html Study Title The influence of home versus clinic anal human papillomavirus sampling on high-resolution anoscopy uptake in the Prevent Anal Cancer Self-Swab Study Key Findings Anal cancer disproportionately affects sexual and gender minority individuals living with HIV. High-resolution anoscopy (HRA) is an in-clinic procedure to detect precancerous anal lesions and cancer. We examined whether […] ➡️➡️➡️

“`html Visual Performance of Optical Films Utilizing Spatio-Temporal Optical Phase Technology Published in Optom Vis Sci. 2024 Apr 1;101(4):195-203 Significance: Spatio-Temporal Optical Phase technology incorporates optical elements applied to standard single-vision spectacle lenses, offering a potential solution for slowing myopia progression. Purpose: This study aimed to evaluate the visual performance of film pairs containing optical […] ➡️➡️➡️

“`html Randomized Placebo-Controlled Clinical Trial of Dutasteride for Reducing Heavy Drinking in Men ABSTRACT Prior studies have shown that dutasteride, commonly used for benign prostatic hypertrophy, can reduce the production of certain neuroactive steroids associated with alcohol’s effects. This study aimed to evaluate the effectiveness and safety of dutasteride in reducing heavy drinking in men. […] ➡️➡️➡️

“`html The Prevent Anal Cancer Self-Swab Study Background Anal cancer disproportionately affects sexual and gender minority individuals living with HIV. High-resolution anoscopy (HRA) is an in-clinic procedure to detect precancerous anal lesions and cancer. We examined whether anal HPV sampling at home versus in a clinic impacts HRA uptake and assessed HRA acceptability. Methods Sexual […] ➡️➡️➡️