Clinical trials

“`html Autosomal Dominant Osteopetrosis (ADO) Study Findings Problem: – ADO is a rare bone disease causing high bone density and skeletal fragility. – Impact on patients’ daily lives not well understood. Solution: – Developed an online registry to collect data on disease progression and patient outcomes. – Aim to measure treatment effects and guide future […] ➡️➡️➡️

“`html Motor Neuron Disease (MND) Clinical Trial Background People with MND often experience high psychological distress due to the progressive nature of the disease. This study aimed to assess the cost-effectiveness of acceptance and commitment therapy (ACT) tailored for MND patients in improving their quality of life. Methods Compared ACT plus usual care with usual […] ➡️➡️➡️

“`html FORZA Trial: Clinical Impact of μQFR, FFR, or OCT Guidance Background The FORZA trial compared the use of FFR or OCT for treatment decisions in patients with intermediate coronary lesions. μQFR, a noninvasive method, was evaluated for its clinical impact in the trial. Methods μQFR was assessed at baseline and after PCI. Primary endpoint: […] ➡️➡️➡️

“`html Assessing the Role of Chest Radiography in Diagnosing Neonatal Respiratory Distress Syndrome Practical Solutions and Value Access to chest radiography (CXR) in resource-limited areas is difficult. CXR is still widely used in diagnosing and grading neonatal respiratory distress syndrome (NRDS). A review of studies with NRDS diagnostic criteria was conducted. Out of 1,686 studies […] ➡️➡️➡️

“`html Practical Solutions and Value in Follicular Lymphoma Treatment Introduction Follicular lymphoma (FL) is a common type of non-Hodgkin lymphoma in Western countries. While FL is generally not curable, there are effective initial therapies and new treatments for relapsed or refractory disease. Treatment Options Initial treatment options for FL include active surveillance, radiotherapy, rituximab monotherapy, […] ➡️➡️➡️

“`html Study Summary The study aimed to assess the effectiveness of using urine samples to detect high-grade cervical precancer (CIN2+) caused by human papillomavirus (HPV) using two different urine collection devices. Key Findings The sensitivity of HPV testing in urine samples collected with the FVU-collection device was 90.3%, higher than the standard pot which had […] ➡️➡️➡️

“`html Study Summary: PD-1 Inhibitor Combined with SOX for Gastric Cancer Gastric cancer (GC) is a common and deadly tumor, often diagnosed at an advanced stage. Postoperative adjuvant chemotherapy for advanced GC has limited effectiveness, leading to high rates of distant metastasis and local recurrence. Objective To assess the safety and effectiveness of combining a […] ➡️➡️➡️

“`html Practical Solutions for Managing Mixed Neuroendocrine Non-Neuroendocrine Neoplasms (MiNENs) MiNENs are complex malignant tumors found in the digestive system, consisting of both neuroendocrine and non-neuroendocrine components. The diverse nature of these tumors, including different cell types and grades, can make their diagnosis and treatment challenging. Defining MiNEN and Addressing Confusion Recent changes in the […] ➡️➡️➡️

“`html Study Summary This study aims to understand the impact of matrix metallopeptidase-9 (MMP9) on arterial smooth muscle cells, atherosclerosis development in diabetic mice, and drug-naïve diabetes patients. Practical Solutions and Value Adding active human MMP9 to smooth muscle cells increased inflammation and initiated atherosclerosis in diabetic mice. In newly diagnosed drug-naïve diabetes patients, serum […] ➡️➡️➡️

“`html Identifying New Therapeutic Targets for COPD Chronic obstructive pulmonary disease (COPD) is a common and serious health issue, but there are limited effective treatment options available. This study aims to find new therapeutic targets for COPD. Practical Solutions and Value Utilizing existing drugs and identifying new therapeutic targets through Mendelian randomization (MR) analysis. Extracting […] ➡️➡️➡️

“`html Scrub Typhus Control Program (STCP) Protocol Scrub typhus, a zoonotic disease, is causing significant illness and death in rural tropical areas due to underdiagnosis and limited access to healthcare. This ongoing issue calls for an urgent public health program to effectively address and manage the disease. Challenges: Underdiagnosis and underreporting due to non-specific clinical […] ➡️➡️➡️

Study on the Impact of Telehealth for COVID-19 Patients in Korea During the COVID-19 pandemic, the Korean government allowed full-scale telehealth care for safety and usability. However, there’s limited research on how telehealth affects the physical and mental health of COVID-19 patients in Korea. Purpose of the Study This study aimed to identify different patterns […] ➡️➡️➡️

“`html Study Summary In a recent study, researchers aimed to develop a gene expression score to predict the clinical benefit of the anti-PD-1 antibody nivolumab in patients with advanced clear cell renal cell carcinoma (RCC). The study integrated data from the CheckMate-009, CheckMate-010, and CheckMate-025 clinical trials. Key Findings A three-gene expression score (3GES) was […] ➡️➡️➡️

“`html Radial Endobronchial Ultrasound (r-EBUS) for Diagnosing Peripheral Pulmonary Lesions (PPLs) Key Findings: The diagnostic yield of r-EBUS for PPLs is approximately 73.4%. Factors influencing diagnostic yield include location and size of the lesion, type and appearance on CT, presence of certain signs, and use of rapid on-site evaluation (ROSE). Overall complications, pneumothorax, and bleeding […] ➡️➡️➡️

“`html Appendicular Osteosarcoma in Dogs: Clinical Trial Results Summary A clinical trial studied two Rottweiler dogs with appendicular osteosarcoma. Despite receiving similar treatment, they had different outcomes. Various techniques were used to analyze their tumors and identify factors influencing their response to treatment. Comparison with a companion cohort of Rottweiler dogs provided new insights into […] ➡️➡️➡️

“`html Summary of Clinical Trial on Shen Gui Capsules for Chronic Heart Failure Study Overview Assessed the effectiveness and safety of Shen Gui capsules (SGCP) as an adjuvant treatment for chronic heart failure (CHF). Reviewed nine randomized controlled trials (RCTs) involving 888 CHF patients. Key Findings Positive Effects: SGCP combined with conventional therapy showed significant […] ➡️➡️➡️

“`html Addressing Gender and Racial Inequalities in Nephrology Key Points: Women from underrepresented racial groups face challenges in kidney disease research due to lack of representation. Systemic biases in healthcare hinder access and quality of care for kidney diseases. Practical Solutions: Recalibrate risk stratification models to include gender- and race-specific factors. Transform healthcare policies to […] ➡️➡️➡️

“`html Colorectal Cancer and Immunotherapy Colorectal cancer (CRC) is a complex disease with low survival rates, especially in advanced stages. Recent advancements in cancer treatment, particularly with immunotherapies targeting immune checkpoints, have shown promise in clinical trials. Practical Solutions and Value Immunotherapies like PD-1 inhibitors have been approved for treating certain types of advanced CRC. […] ➡️➡️➡️

“`html Practical Solution for GM2 Gangliosidoses Challenges Addressed: Rare lysosomal storage disorder causing central nervous system damage Lack of feasible clinical outcome assessments for GM2 Value Offered: Potential for improved outcomes with early diagnosis and pharmacotherapies Development of Infantile GM2 Clinical Rating Scale for health-related function assessment “` ➡️➡️➡️

“`html Study Summary: Comparing Chemotherapy Cycles for Small-Cell Lung Cancer Researchers compared the outcomes of patients with limited-stage small-cell lung cancer (LS-SCLC) who received either 6 cycles or 4-5 cycles of chemotherapy combined with thoracic radiotherapy (TRT). Key Findings: Patients who received 6 cycles of chemotherapy showed significant improvement in overall survival (OS) and progression-free […] ➡️➡️➡️