Long-Term Changes of Urinary Exosomal Peptide Levels After Thyroidectomy in Patients with Thyroid Cancer: A Prospective Observational Study

Long-Term Changes of Urinary Exosomal Peptide Levels After Thyroidectomy in Patients with Thyroid Cancer: A Prospective Observational Study

ABSTRACT

The study aimed to investigate the potential of urine exosomal peptide levels to predict the risk of thyroid cancer recurrence after thyroidectomy.

METHODS

Patients newly diagnosed with papillary thyroid cancer and who had undergone thyroidectomy were included. Urine samples were collected at 12 months and 24 months after enrollment, and urine exosomes containing different peptides were analyzed.

RESULTS

70 patients were enrolled, categorized by the time interval between surgery and enrollment. No recurrences were observed during the 2-year follow-up. No significant differences were found in serum proteins or urine exosomal peptides between groups or time intervals. Known risk factors for high-risk thyroid cancer showed only mild correlation with serum protein levels and urine exosomal peptides.

CONCLUSION

The study revealed the long-term fluctuation ranges of serum proteins and urine exosomal peptides in thyroid cancer patients post-thyroidectomy. Concentrations of serum proteins or urine exosomal peptides within certain ranges may indicate a lower risk of thyroid cancer recurrence in high-risk patients.

TRIAL REGISTRATION: ClinicalTrials.gov: NCT03488134.

PMID: 38803995 | PMC: PMC11129743 | DOI: 10.2147/IJN.S458931

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