Clinical trials

Understanding the Trial Results The study looked at a new treatment called resiniferatoxin (RTX) for patients with severe cancer pain that didn’t get better with usual pain management. Here’s what was found: What Worked? RTX helped reduce pain by 38%. Patients reported their worst pain level dropping from 8.4 to 5.2 on a scale of […] ➡️➡️➡️

Understanding the Trial Results This study looked at a treatment for early-stage knee osteoarthritis (OA), a common condition that causes pain and disability. The researchers tested a single dose of a medication called IncobotulinumtoxinA (BoNT-A) on 45 patients. Here’s what they found: What Worked: Patients experienced a significant reduction in pain after receiving the treatment. […] ➡️➡️➡️

Understanding the Trial Results The study looked at a treatment called injectable platelet-rich fibrin (I-PRF) for patients with alveolar osteitis (AO), a painful condition that can happen after tooth extraction. The results showed that I-PRF significantly reduced pain compared to standard treatment. What Worked: Patients who received I-PRF reported less pain on the seventh day […] ➡️➡️➡️

Understanding the Impact of Simulation Training on Managing Postpartum Hemorrhage What Worked? The study found that healthcare providers who received simulation training showed better skills and knowledge in managing postpartum hemorrhage (PPH) compared to those who only had theoretical training. Specifically, the intervention group improved their test scores significantly after simulation training, while the control […] ➡️➡️➡️

Understanding the MECT-RESIST Trial Results What the Trial Tested This study looked at whether maintenance electroconvulsive therapy (mECT) combined with standard treatment (called treatment as usual, or TAU) helps prevent relapse in patients with clozapine-resistant schizophrenia (CRS) better than standard treatment alone. What Worked? If mECT shows better results, it could keep more patients relapse-free […] ➡️➡️➡️

Understanding the Impact of Long-Term Conditions on Dementia and Sleep Sleep problems are common for people with dementia and can be tough for both them and their families. Many people with dementia also have other long-term health conditions (LTCs). This study looked at how these LTCs affect sleep and dementia. What We Learned from the […] ➡️➡️➡️

Understanding the Benefits of Internet Hospital Follow-Up for Epilepsy Patients What Worked? Patients receiving follow-up care through Internet hospitals (IHs) reported a better quality of life compared to those who received traditional outpatient follow-up. Improvements were seen in anxiety and depression levels among patients using IHs. Specific areas of improvement included emotional well-being, energy levels, […] ➡️➡️➡️

Objective of the Study This study looked at whether allowing children and teens to see a physiotherapist directly in the emergency department (ED) for muscle and bone issues would be helpful compared to the usual care from a doctor. What Worked? The study successfully enrolled 53% of eligible patients in just 2 months. 92% of […] ➡️➡️➡️

Understanding the Trial Results The study compared two medications, esketamine and remifentanil, for patients with septic shock who needed mechanical ventilation. Here’s what we found: What Worked? Less Norepinephrine Needed: Patients who received esketamine needed less norepinephrine, a medication used to stabilize blood pressure, compared to those who received remifentanil. Stabilizing Hemodynamics: Esketamine may help […] ➡️➡️➡️

Understanding the Study Results This study developed a new machine learning model to diagnose tuberculous pleural effusion (TPE) quickly and without invasive procedures. The model uses routine lab tests to provide accurate results. What Worked: The Light Gradient Boosting Machine (LGBM) model was the most effective among ten tested models. It achieved high accuracy, with […] ➡️➡️➡️

Understanding the Study Results This study looked at how well a treatment called Dextrose prolotherapy works for women with a specific jaw problem known as Temporomandibular Joint (TMJ) Disc Displacement without Reduction (DDwoR). This condition can cause pain and make it hard to open the mouth. The study involved 20 women who had not found […] ➡️➡️➡️

Understanding the Trial Results This clinical trial looked at whether combining a drug called tislelizumab with capecitabine could help patients with biliary tract cancers (BTC) after surgery. The main goal was to see if this combination could prevent cancer from coming back compared to using capecitabine alone. What Worked? The combination of tislelizumab and capecitabine […] ➡️➡️➡️

Understanding the Study Results The study looked at how depression affects cognitive testing in older adults. It specifically used a test called the Montreal Cognitive Assessment (MoCA) to see if people with different levels of depression performed differently. Here’s what they found: No Differences Found: People with no depression, mild depression, or severe depression scored […] ➡️➡️➡️

Study Results: What Worked and What Didn’t The study tested a new tool called the Fatigue Differential Diagnostic Aid (FDDA) to help doctors understand and manage unexplained fatigue in patients. Here’s what we found: What Worked: Patients using the FDDA reported feeling less fatigue compared to those receiving usual care. Patients were more satisfied with […] ➡️➡️➡️

Understanding the Trial Results This study focused on children and teenagers with major depressive disorder (MDD). The researchers looked at two important substances in the body: cortisol, a stress hormone, and anandamide (AEA), which is linked to mood. They found that: Children with MDD had lower levels of both cortisol and AEA compared to healthy […] ➡️➡️➡️

Understanding the Trial Results The trial tested a new treatment called tislelizumab, given after surgery for patients with resectable recurrent nasopharyngeal carcinoma (rNPC). Here’s what we found: What Worked? Tislelizumab improved the time patients lived without their cancer returning (progression-free survival or PFS). In the tislelizumab group, 94% were still cancer-free after one year, compared […] ➡️➡️➡️

Understanding the Trial Results The trial compared two methods for colonoscopy: water-assisted colonoscopy (WAC) and conventional carbon dioxide insufflation colonoscopy (CC). It involved beginner endoscopists who had performed fewer than 150 procedures before. What Worked? WAC was found to be a safe and effective alternative to CC. Procedure times were similar for both methods. Patients […] ➡️➡️➡️

Trial Results Explained The study tested a treatment for stage-II periodontitis, which is a type of gum disease. It looked at three groups: First group: Received professional cleaning plus injectable platelet-rich fibrin (I-PRF) with vitamin C. Second group: Received professional cleaning plus I-PRF without vitamin C. Third group: Received only professional cleaning. Here’s what the […] ➡️➡️➡️

Understanding the Trial Results This study looked at how well sensorimotor training (SoMT) combined with core strength training (CST) can help adults with low back pain and scoliosis. Here’s what they found: What Worked? The combination of SoMT and CST may reduce low back pain significantly. Patients may also see improvements in their overall health […] ➡️➡️➡️

Understanding the Trial Results This research compares two types of treatments for adults with post-traumatic stress disorder (PTSD) who have experienced multiple traumatic events. The two treatments are: Spaced Trauma-Focused Treatment (S-TFT): This is the standard treatment, where patients attend weekly sessions. Massed Trauma-Focused Treatment (M-TFT): This involves more frequent sessions, potentially leading to faster […] ➡️➡️➡️