Clinical trials

Predicting Postoperative Circulatory Complications in Older Patients This study focuses on using machine learning to identify key factors that can help predict circulatory complications after surgery in older patients. Study Overview The research analyzed data from a clinical trial involving 1,720 elderly patients (ages 60-90) who underwent major non-cardiac surgeries in five hospitals in Beijing, […] ➡️➡️➡️

Objective This study aimed to explore how low-volume high-intensity interval training (HIIT) and walking, compared to no exercise, affect insulin sensitivity and metabolism in individuals with prediabetes. Study Design Participants were divided into four groups: Control group (no exercise) HIIT group (3 sprint sessions of 20 seconds each, three times a week) HIIT + Walking […] ➡️➡️➡️

Background Slow-transit constipation is a condition that currently lacks effective treatments. Traditional therapies often have side effects and limited success. A new approach called auricular acupoint stimulation may help by stimulating specific points in the ear to improve gut function, but its effectiveness is still being studied. Study Overview In a recent study, 60 patients […] ➡️➡️➡️

Study Overview This study aimed to compare two treatment approaches for patients with stage N2-3 nasopharyngeal carcinoma. The first approach involved four cycles of neoadjuvant chemotherapy using docetaxel and cisplatin, followed by concurrent chemoradiotherapy. The second approach was concurrent chemoradiotherapy alone. Key Findings After following 186 participants for an average of over six years: The […] ➡️➡️➡️

Study Overview This study looked at how social conflict affects people with high hostility and whether a medication called citalopram can help reduce their negative reactions. Key Findings No Overall Change: The study found that citalopram did not significantly change the overall levels of social conflict or hostile mood. Reduced Hostile Reactions: However, it did […] ➡️➡️➡️

Study Overview This study looked at how two treatments—high-intensity laser therapy (HILT) and short-wave diathermy (SWD)—combined with exercise can help patients with knee osteoarthritis (OA). The goal was to see which treatment is more effective in reducing pain and improving physical function and quality of life. Participants and Methods Sixty patients with knee OA were […] ➡️➡️➡️

Study Overview The study evaluated how well the GeneActiv actigraphy device measures sleep compared to traditional polysomnography (PSG) in older adults who reported sleep issues. Methods 12 participants, averaging 67.7 years old, underwent two nights of sleep monitoring with both GeneActiv actigraphy and PSG, spaced two weeks apart. Key sleep parameters were measured, including: Time […] ➡️➡️➡️

Introduction Osteoarthritis is a common joint disease affecting many people worldwide. Improving treatment options is essential for enhancing patients’ quality of life. Study Overview This study compared two types of total knee arthroplasty (TKA): personalized (custTKA) and standard (convTKA). The goal was to see how each method impacted patients’ walking, posture, and overall health after […] ➡️➡️➡️

Background Muscle pain is commonly caused by a condition known as myofascial pain syndrome, which involves sensitive areas called trigger points (TrP). While some physiotherapy treatments help, it’s important to understand how they compare to each other, especially regarding long-term effects and placebo impacts. Study Overview This study aimed to compare two treatments for upper […] ➡️➡️➡️

Study Overview This study focused on radiation-induced dermatitis (RID), a common side effect of radiotherapy in cancer patients. The goal was to test an herbal gel to see if it could prevent RID and its symptoms. Study Design Cancer patients were divided into two groups: Prophylactic Group: Received the herbal gel one day before starting […] ➡️➡️➡️

Study Overview The PAOLA-1/ENGOT-ov25 trial studied how well a treatment combining olaparib and bevacizumab works for patients with advanced ovarian cancer that has certain genetic characteristics. Key Findings Patients who received olaparib along with bevacizumab had longer periods without cancer progression compared to those who only received bevacizumab. Progression-Free Survival For higher-risk patients with HRD-positive […] ➡️➡️➡️

Background Many women with high-risk HPV (hrHPV) can heal from infections without treatment. The World Health Organization suggests using Visual Inspection with Acetic Acid (VIA) as a follow-up test during cervical cancer screenings. However, there are concerns about how accurate this test is. This study looked at how well VIA works, both with and without […] ➡️➡️➡️

Study Overview This study looks at how using an intrauterine manipulator during a hysterectomy for endometrial cancer affects patient outcomes. Previous studies have suggested that this tool might lead to worse results, but more research is needed. Key Objectives The main goal is to compare the 4-year recurrence-free survival rates between two groups of patients: […] ➡️➡️➡️

“`html Study Overview This study aimed to see if 10 sessions of hyperbaric oxygen therapy (HBOT) could improve the health and quality of life for patients suffering from long COVID compared to a placebo treatment. Study Design The research was a double-blind, placebo-controlled trial conducted at a university hospital in Sweden. It involved healthy adults […] ➡️➡️➡️

Background Calcium and magnesium levels in the blood are important for blood clotting and may affect how brain bleeding (intracerebral hemorrhage or ICH) worsens. This study aimed to maintain specific calcium and magnesium levels for three days after patients were admitted to the hospital. Methods This study was done at multiple hospitals from 2019 to […] ➡️➡️➡️

Background Inflammation can harm the heart during and after a procedure called percutaneous coronary intervention (PCI). Vitamin D can help reduce inflammation. This study looked at how two forms of Vitamin D—calcitriol and cholecalciferol—affect inflammation in patients undergoing PCI. Study Overview In this clinical trial, patients scheduled for PCI were divided into two groups: one […] ➡️➡️➡️

Study Overview This study looked at the MiniMed 780G system, a new diabetes technology, and how it compares to older insulin treatments for people with type 1 diabetes (T1D) in the US. Key Findings The MiniMed 780G system helps improve blood sugar control. It is cost-effective, meaning it provides good health benefits for the money […] ➡️➡️➡️

Understanding Depression Monitoring in Clinical Trials Objective of the Study This study examined how two methods of measuring depression—Ecological Momentary Assessment (EMA) and Weekly Questionnaires (WQA)—compare in clinical trials. We wanted to see how well each method could track changes in depressive symptoms and negative thinking, and how accurately they predict overall patient functioning. Study […] ➡️➡️➡️

Study Overview This study explored how structured dietary and exercise interventions can help delay diabetes in prediabetic patients. Prediabetes increases the risk of developing diabetes, and the researchers aimed to see if specific lifestyle changes could make a difference. Participants A total of 542 prediabetic patients participated in the study. They were selected based on […] ➡️➡️➡️

Background More patients are using diabetes apps on their smartphones to manage their condition. However, there is limited research on the effectiveness of these apps in China. Objective This study aimed to assess how well a popular diabetes app helps Chinese patients with type 2 diabetes manage their blood sugar levels. Methods The study was […] ➡️➡️➡️